Chemical Composition, Antioxidant and Anti-tumor Activities of the Aerial Parts of Cometes abyssinica R.Br. ex Wall
Ahmed AM Abdelgawad1,2★★ Corresponding author
- 1Department of Medicinal and Aromatic Plants, Desert Research Center, Cairo, EGYPT.
- 2Department of Chemistry, Faculty of Science, Jazan University, Jizan, SAUDI ARABIA.
CORRESPONDENCE
Ahmed AM Abdelgawad
Department of Medicinal and Aromatic Plants, Desert Research Center, Cairo, EGYPT.
Received: 25-03-2022; Revised: 03-10-2022; Accepted: 06-02-2023.
Volume 57, Issue 2 · pp. 459–465 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.2.56
ABSTRACT
An in vitro bioassay-guide revealed that the methanolic extract of the aerial parts of Cometes abyssinica had considerable inhibitory activity against colon (HCT-116) and hepatocellular (HepG2) carcinoma cell lines with IC50 24.4 and 29.9 μg/mL, respectively, compared to the drug reference Cisplatin. On the other hand, all studied extracts exhibited weak antioxidant activities using the DPPH scavenging assay with IC50 values between 543-826.4 μg/mL. Phytochemical investigation of the methanol and ethyl acetate extracts of C. abyssinica led to the isolation of five flavonoid compounds: Formononetin 1, Daidzein 2, Eriodictyol 3, Taxifolin 4, and kaempferitrin 5. The chemical structure of the isolated compounds was identified based on their physicochemical and spectroscopic analyses.
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Abdelgawad, A. A. (2023). Chemical Composition, Antioxidant and Anti-tumor Activities of the Aerial Parts of Cometes abyssinica R.Br. ex Wall. Indian Journal of Pharmaceutical Education and Research, 57(2), 459–465. https://doi.org/10.5530/ijper.57.2.56