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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Hazelnut Has Potency on Wound Healing Associated with Immunohistochemical Biomarkers

Alper Çirakli1★, Havva Erdem2★ Corresponding author

  1. 1Department of Orthopedic and Traumatology, Ordu University, Faculty of Medicine, Ordu, TÜRKIYE.
  2. 2Department of Pathology, Ordu University, Faculty of Medicine, Ordu, TÜRKIYE.

CORRESPONDENCE

Alper Çirakli

Dr. Alper Çıraklı,Department of Orthopedics and Traumatology, Ordu University, Faculty of Medicine, Altinordu, Ordu-52200, TÜRKIYE.

alperomu@gmail.com

Received: 21-05-2022; Revised: 05-03-2023; Accepted: 21-04-2023.

Volume 57, Issue 3 · pp. 748–755 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.3.91

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ABSTRACT

Background: In this study, it was aimed to evaluate the impact of hazelnut on wound healing by using its immunohistochemical impacts on Claudin-5, Tumor Necrosis Factor-alpha (TNF-a), tumor Protein-63 (p63), and Insulin-like Growth Factor-1 (IGF-1) expression. Materials and Methods: Seventy-two male Wistar-Albino rats were used. Nine groups with 8 rats each group, and 3, 7, and 14 days groups were formed as oral, local, and control groups. Samples obtained from rats were evaluated with these immunohistochemical biomarkers. Results: Claudin-5 scores were found to be statistically significant in the oral group on all days (p=0.007, p=0.002, p=0,014). TNF-a scores were found to be statistically significant on the 3rd and 7th days in the local and oral groups (p=0.040, p=0.001). p63 scores were found to be statistically significant in the oral group when looking at the 14th day values (p=0.007). IGF-1 scores were found to be statistically significant on the 7th and 14th days in the local group (p=0.040). Conclusion: It was determined that hazelnut has positive impact on wound healing by stimulating the claudin-5, TNF-a, p63, and IGF-1expression levels.

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    Çirakli, A., & Erdem, H. (2023). Hazelnut Has Potency on Wound Healing Associated with Immunohistochemical Biomarkers. Indian Journal of Pharmaceutical Education and Research, 57(3), 748–755. https://doi.org/10.5530/ijper.57.3.91