Article · Volume 57, Issue 3S · pp. s742–s748
Multicomponent Synthesis, Characterization of Novel Pyrimidine Derivatives with Anti-cancer Potential
Swetha Devidi1, M Swamivel Manickam1, R Suresh1
- 1Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.
Abstract
Background: Design and development of target specific anti-cancer agents is a central research goal.Materials and Methods: Substituted pyrimidines were synthesized from substituted enamine, triethoxy methane and ammonium acetate. Characterization was done using IR, 1H-NMR, and mass spectra. Cytotoxicity was tested using MTT Assay on A 549, B16F10, SiHA, and MCF-7 cells.Results: Synthesized derivatives displayed noticeable cytotoxicity against tested cancer cell lines.Conclusion: Evaluated cell lines were susceptible to the novel pyrimidine derivatives, which may be transformed into potent anti-cancer leads.
Keywords: Multicomponent synthesis; Pyrimidines; Anti-cancer
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