Multicomponent Synthesis, Characterization of Novel Pyrimidine Derivatives with Anti-cancer Potential
Swetha Devidi1★, M Swamivel Manickam1, R Suresh1★ Corresponding author
- 1Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.
CORRESPONDENCE
Swetha Devidi
Annamalai University, Annamalai Nagar-608002, Tamil Nadu, INDIA.
Received: 25-09-2022; Revised: 30-01-2023; Accepted: 23-06-2023.
Volume 57, Issue 3S · pp. s742–s748 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.3s.84
ABSTRACT
Background: Design and development of target specific anti-cancer agents is a central research goal. Materials and Methods: Substituted pyrimidines were synthesized from substituted enamine, triethoxy methane and ammonium acetate. Characterization was done using IR, 1H-NMR, and mass spectra. Cytotoxicity was tested using MTT Assay on A 549, B16F10, SiHA, and MCF-7 cells. Results: Synthesized derivatives displayed noticeable cytotoxicity against tested cancer cell lines. Conclusion: Evaluated cell lines were susceptible to the novel pyrimidine derivatives, which may be transformed into potent anti-cancer leads.
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Devidi, S., Manickam, M. S., & Suresh, R. (2023). Multicomponent Synthesis, Characterization of Novel Pyrimidine Derivatives with Anti-cancer Potential. Indian Journal of Pharmaceutical Education and Research, 57(3S), s742–s748. https://doi.org/10.5530/ijper.57.3s.84