Volume 57, Issue 3S

2023 · pp. s701–s709 · 39 articles

Volume: 57
Issue: 3S
Published: 2023
Pages: s701–s709
Articles: 39
Sections: 1
ISSN: Online - 0019-5464
Journal: IJPER

In this issue

Article
Herbal Nanoparticles: A Commitment towards Contemporary Approach
Pragyan Parimita Mansingh, Lopamudra Adhikari, Moonmun Dhara
pp. s465–s480 · DOI: 10.5530/ijper.57.3s.55 · Published 2023
Herbal medicines have been used extensively since ancient times in almost every region of the world and are regarded by patients and doctors as having the best therapeutic value or effect because they have very few or le…
Article
Nanoemulgel: A Smarter Topical Lipidic Emulsion-based Nanocarrier
Suraj Mandal, Prabhakar Vishvakarma
pp. s481–s498 · DOI: 10.5530/ijper.57.3s.56 · Published 2023
In the last few decades, researchers have put a lot of time and effort into making new pharmaceuticals. As a result, there are now a huge number of pharmacological chemicals that can be used to treat a wide range of dise…
Article
Analyzing Biosimilars in Brazil: Comprehensive Specifications of the Regulatory System
Kethareshwara Sujatha Deeksha, Balamuralidhara Veeranna, Gowthami Kodlahalli Ravindra
pp. s499–s506 · DOI: 10.5530/ijper.57.3s.57 · Published 2023
The largest nation in South America, Brazil, is now the world's second-largest market for pharmaceuticals thanks to the country's economic growth. The Brazilian Health Surveillance Agency, also known as the National Agen…
Article
An Analysis of the Extent of Intra and Inter-rater Variability in OSCE
Swanand Shrikant Pathak, Gaurav Vedprakash Mishra, Rupesh Anna Warbhe
pp. s507–s510 · DOI: 10.5530/ijper.57.3s.58 · Published 2023
Background: OSCE is an objective structured clinical examination, though the tool is designed to increase the objectivity in the examination of the clinical cases, the inter and intra rater variability of the tool needs …
Article
Enhancement of the Solubility of Lipophilic Drug by Self-Micro Emulsifying Drug Delivery System (SMEDDS) For Oral Administration
Purushottam Gangane, Kiran Singh, Vijaya Rabade
pp. s511–s519 · DOI: 10.5530/ijper.57.3s.59 · Published 2023
Aim: The aim of this research work is the formulation, development and evaluation of Self-Micro Emulsifying Drug Delivery System (SMEDDS). Background: Zileuton, a drug that is poorly soluble in water, was formulated with…
Article
Luliconazole Loaded Niosomal Topical Gel: Factorial Design, in vitro Characterization and Antifungal Study
Nirmal Shah, Rahul Prajapati, Dipti Gohil, Chintan Aundhia, Piyush Sadhu, Sunil Kardani
pp. s520–s527 · DOI: 10.5530/ijper.57.3s.60 · Published 2023
Aim/Background: This research work intended to make use of prospective advantages of niosomes for the improvement in topical delivery of poorly soluble luliconazole. Materials and Methods: Luliconazole, an anti-fungal ag…
Article
Nanoemulgel Formulation of Tetrahydrocurcumin with Efficient Anti-inflammatory Effect for the Treatment of Skin Disorders
Kiran Sharma
pp. s528–s539 · DOI: 10.5530/ijper.57.3s.61 · Published 2023
Introduction: Tetrahydrocurcumin (THC) is a partially reduced white metabolite of curcumin which does not impart yellowish colour on skin due to which it seemed to be a promising topical agent compared to curcumin which …
Article
Multiparticulate Floating Beads an Aid to Enhance Therapeutic Efficacy of Rabeprazole
Prajakta Magdhut, Panchaxari Mallappa Dandagi, Umashri Annappa Kokatanur, Archana Sidagouda Patil
pp. s540–s547 · DOI: 10.5530/ijper.57.3s.62 · Published 2023
Background: Rabeprazole sodium is a newer generation anti-ulcer drug with short half-life and low bioavailability. Present research work is an attempt to design novel floating beads of Rabeprazole sodium in multiparticul…
Article
Solid State Characterization and Miscibility of Raltegravir in Soluplus Using Solid Dispersion Technology
Dani Lakshman Yarlagadda, Akshatha Manohar Nayak, Krishnamurthy Bhat
pp. s548–s554 · DOI: 10.5530/ijper.57.3s.63 · Published 2023
Background: Raltegravir Potassium (RTGP), a BCS class II drug used in the treatment of HIV, has minimal solubility in the aqueous medium, resulting in poor bioavailability; Further, RTGP poor dissolution and limited solu…
Article
Preparation and Optimization of Microwave-Assisted Ball-Milled Olmesartan Medoxomil with Chitosan Using Full 3^2 Factorial Design
Atul Shivaji Gurav, Ajit Shankarrao Kulkarni
pp. s555–s563 · DOI: 10.5530/ijper.57.3s.64 · Published 2023
Introduction: The anti-hypertensive drug Olmesartan Medoxomil (OLM), a BCS II drug, works by inhibiting the action of angiotensin II on AT1 receptors. Objectives: The purpose of the study was to enhance solubility and st…
Article
Chitosan–Sesbania Gum Mediated pH-Responsive Polyelectrolyte Complexes for Targeted Delivery of Diclofenac Sodium: Preparation and Spectroscopical Evaluation
Vipul Chaudhari, Shraddha Tawade, Sopan Nangare, Kirti Rajput, Nitin Shirsath, Piyush Bafna, Laxmikant Zawar
pp. s564–s572 · DOI: 10.5530/ijper.57.3s.65 · Published 2023
Background: The implementation of chitosan as an enhanced vehicle for drug delivery is an interesting domain in the pharmaceutical dosage form. The combination of commonly accessible natural polysaccharides like gum may …
Article
Formulation and Evaluation of Antifungal Drug Containing Mucoadhesive Tablet for Vaginal Candidiasis
Pranita Sunil Kanojiya, Rita Naresh Wadetwar, Amita Prasanna Godbole
pp. s573–s586 · DOI: 10.5530/ijper.57.3s.66 · Published 2023
Objectives: Female population frequently seeks medical consultation for the vaginal candidiasis. Voriconazole (VOR) is a BCS class II antifungal drug with low aqueous solubility and hence inclusion complex was formulated…
Article
Formulation and Evaluation of Nano Co-Crystal Based Oral Disintegrating Tablet of Ezetimibe
J Puneeth, Preethi Sudheer, Shiji John, Darshan PR, Jyothi Y
pp. s587–s598 · DOI: 10.5530/ijper.57.3s.67 · Published 2023
Background: Low solubility, poor permeability, and hepatic drug degradation are the primary factors responsible for the poor bioavailability issues of orally administered drugs. Ezetimibe, a biopharmaceutics classificati…
Article
Bioprospecting of Actinomycetes from Diverse Ecosystems for Antimicrobial Activity
Amita Prasanna Godbole, Rita Naresh Wadetwar, Sunita Bhupesh Bundale, Nandita Nashikkar, Pranita Sunil Kanojiya
pp. s599–s609 · DOI: 10.5530/ijper.57.3s.68 · Published 2023
Background: Actinomycetes are unique and ubiquitous organisms in nature and are historically holding first position as one of the major antibiotic producers. The aim of the study was screening and pre-treatments of soil,…
Article
Evaluation of Cognition Enhancing Activities of Telmisartan, Nimodipine and their Combination in REM Sleep Deprived Wistar Rats
Mohan Kumar Siddalingappa, Amberkar Mohanbabu Vittalrao, Meena Kumari Kamalkishore, Vinay Mamulpet
pp. s610–s619 · DOI: 10.5530/ijper.57.3s.69 · Published 2023
Background: Sleep Deprivation (SD) may lead to the failure of advanced neural functions, including decision-making, learning and memory. Studies show that nimodipine plays a role in intracellular Ca^2+ to reduced influx …
Article
Neuroprotective Effects of Withaferin-A Nanoparticles on Scopolamine Rat Model of Alzheimer’s Disease
Madhu Subramanian, Komala Munuswamy, Pandian Pitchaimuthu
pp. s620–s625 · DOI: 10.5530/ijper.57.3s.70 · Published 2023
Background: Alzheimer's Disease (AD) suffers from dementia more often in 65-year or older patients. Symptoms of AD's are linked to disease-causing neurons, and current pharmacological therapies inadequately regulate dead…
Article
Effect of Topiramate on Mitochondrial Biogenesis and Neuroinflammation in Chronic Constriction Injury and Streptozotocin-induced Peripheral Neuropathy
Abdulla K. Sherikar, Aman B. Upaganlawar, Chandrashekhar D. Upasani
pp. s626–s638 · DOI: 10.5530/ijper.57.3s.71 · Published 2023
Background: Because neuropathic pain is currently a poorly understood medical condition, there is a need to identify a more effective therapeutic drug with a low toxicity profile. Purpose: To address the behavioural, oxi…
Article
Evaluation of Cytotoxic Potential of Classical Siddha Medicine Padikara Parpam in Human Monocytic Leukemic Cell Lines (THP-1)
Aswathy Karanath-Anilkumar, Ganesh Munuswamy-Ramanujam, Vinayak Soman, Shree Devi Munusamy Sampangiramulu, Sathiyarajeswaran Parameswaran
pp. s639–s643 · DOI: 10.5530/ijper.57.3s.72 · Published 2023
Introduction: Padikara Parpam (PP), is one among the highly regarded Siddha medicine that is been traditionally claimed for its anti-proliferating and anti-carcinogenic properties. Objectives: In the present work, we inv…
Article
Investigation of in vitro and in vivo Pursuits of Laurus nobilis Extract on Acetic Acid-induced Ulcerative Colitis in Wistar Rats
Suliman Abdullah Al-Omran, Virdala Chinnikrishnaiah, Vakkalagadda Siva Ganesh, Prakash Goudanavar, Nimbagal Raghavendra Naveen, Santosh Fattepur, Girish Meravanige Basavarajappa, Predeepkumar Narayanappa Shiroorkar, Mallikarjun Telsang, Sreeharsha Nagaraja
pp. s644–s651 · DOI: 10.5530/ijper.57.3s.73 · Published 2023
Background: The ethanolic extract of Laurus nobilis possesses an anti-inflammatory effect, which will protect against acetic acid-induced Ulcerative colitis by inhibiting endogenous free radicals. Objectives: The work ha…
Article
Haematinic Activity of Nagaphani (Opuntia elatior Mill.) Swarasa through its Betalain Content on Phenylhydrazine-induced Haemolytic Anaemia in Rats
Vaidehi Vadhvana, Rabinarayan Acharya, Mukeshkumar Nariya
pp. s652–s659 · DOI: 10.5530/ijper.57.3s.74 · Published 2023
Aim: Woody shrubs of Nagaphani (Opuntia elatior Mill.) (Family: Cactaceae), bearing a pear shaped fleshy fruits rich in betalain content, vitamins and has antioxidant activities. Its fruits showed a great demand for its …
Article
Formulation and Evaluation of Nanoemulsion of the Phenolic Content of Foeniculum vulgare for Antidepressant and Antihypertensive Potentiality
Sanjita Das, Sweta Rani
pp. s660–s666 · DOI: 10.5530/ijper.57.3s.75 · Published 2023
Objectives: Foeniculum vulgare (common name: fennel; family: Umbelifereae) is a well-documented plant with various medicinal properties to manage different types of disease. Depression and hypertension are associated wit…
Article
Bioactivity-guided Isolation of Phytoconstituents from Saraca asoca Seeds for Anti-asthmatic Potential
Chandrakant Prabhu Rathod, Mahavir Ghante
pp. s667–s677 · DOI: 10.5530/ijper.57.3s.76 · Published 2023
Objectives: It is interesting to consider biologically active substances derived from natural sources as potential novel medications for infectious disorders. Saraca asoca is an indigenous medicinal plant with lots of tr…
Article
Ethnobotanical Study of Medicinal Plants Used Traditionally for Managing Cuts and Wounds by the Rural People of Kailashpur, Assam, India
Pal Gogoi, Saikat Sen
pp. s678–s689 · DOI: 10.5530/ijper.57.3s.77 · Published 2023
Background: Folk medicinal knowledge of plants is vital in primary health care management system, predominantly in rural and remote areas. Managing cuts and wounds continues to be a significant healthcare issue. Material…
Article
Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats
Dhanaraju Kavitha, Ramakrishnan Padmini, Magharla Dasaratha Dhanaraju, Chandravadivelu Gopi, Deepan Thiyagarajan, Alekkhya Veeramaneni
pp. s690–s700 · DOI: 10.5530/ijper.57.3s.78 · Published 2023
Background: Syringodium isoetifolium seagrass has bioactive constituents with potential pharmacological uses, but their use is limited. Materials and methods: Wistar albino rats were split into five groups. Except for gr…
Article
Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats
Bixia Xu, Abdullah A. Alarfaj, Abdurahman Hajinur Hirad, Nandakumar Natarajan, Petchi Iyappan, Samer Hasan Hussein Al Ali
pp. s701–s709 · DOI: 10.5530/ijper.57.3s.79 · Published 2023
Background: Diabetes mellitus is among the most serious public health problems worldwide. Materials and Methods: 35mg/kg STZ was injected to rats for stimulating diabetes. Then rats were treated with 25mg/kg of brassinin…
Article
In vitro and in vivo Antidiabetic Activity of Ag Nanoparticles Mediated from Gymnemic Acid I and II
Navanita Sivaramakumar, Kalakotla Shanker
pp. s710–s717 · DOI: 10.5530/ijper.57.3s.80 · Published 2023
Background: Gymnema sylvestre is traditionally used to treat diabetes in Asia. Materials and methods: GA-I and GA-II were docked to PTP 1B. Nanoparticles were produced using centrifugation green synthesis. Results: Blood…
Article
Evaluation of Anti-obesity Activity of n-hexane and Methanolic Extracts of Cajanus cajan Linn. Seeds Using Enzymatic Methods
Sakshi Sharma, Anjna Rani
pp. s718–s723 · DOI: 10.5530/ijper.57.3s.81 · Published 2023
Objectives: To evaluate the in vitro anti-obesity activity of Cajanus cajan Linn. seeds. Materials and Methods: Phytochemical screening and in vitro studies on pancreatic lipase and alpha-glucosidase activity were perfor…
Article
Isolation and Functioning Investigation of Salvia hispanica Seed Mucilage as a Potential Sustained Release Carrier for Water Soluble Drug
Dibya Sundar Panda, Madhusmruti Khandai
pp. s724–s733 · DOI: 10.5530/ijper.57.3s.82 · Published 2023
Background: Natural biopolymers or hydrogels are explored to sustain release of water-soluble drugs. Materials and Methods: Mucilage was isolated from Salvia hispanica seeds. Gelispheres loaded with Losartan Potassium (L…
Article
The Formation Analysis of Ca (II), Mg (II), Zn (II) and 5-Hydroxysalicylic Acid Binary Complexes in Cetyltrimethylammonium Bromide Cationic Micelles
Malla Ramanaiah, Sattaru Gouthamsri
pp. s734–s741 · DOI: 10.5530/ijper.57.3s.83 · Published 2023
Aim: The aim of the study is to confirm the species formed and validate models by statistical treatment. Materials and Methods: Alkali metric titrations were carried out in CTAB-water mixtures using sodium hydroxide. Res…
Article
Multicomponent Synthesis, Characterization of Novel Pyrimidine Derivatives with Anti-cancer Potential
Swetha Devidi, M Swamivel Manickam, R Suresh
pp. s742–s748 · DOI: 10.5530/ijper.57.3s.84 · Published 2023
Background: Design and development of target specific anti-cancer agents is a central research goal. Materials and Methods: Substituted pyrimidines were synthesized from substituted enamine, triethoxy methane and ammoniu…
Article
Synthesis of Cyclopyrrolidine Clubbed with Oxadiazole Bases and Evaluation of their Anti-Diabetic Activity through in vivo Model
Megha Tukaram Salve, Shailaja Jadhav
pp. s749–s757 · DOI: · Published 2023
Background and Aim: Based on inhibitors of DPP-IV, there is a fantastic method for creating anti-diabetic medications. These inhibitors regulate diabetic patients' blood sugar levels to prevent difficulties with their he…
Article
Understanding the Trending of Laboratory Investigations as Part of Quality Management Systems-A Quality Assurance Perspective
Anupriya Naduparambil Reji, Marina Koland, Sandeep Divate Satyanarayana
pp. s758–s765 · DOI: · Published 2023
Background: In the pharmaceutical sector, the effectiveness of the laboratory and its compliance with regulatory standards is critical in establishing an effective Quality Management System (QMS). Objectives: The present…
Article
Stability Indicating Reverse Phase-High Performance Liquid Chromatography Method for Simultaneous Estimation of Cabotegravir and Rilpivirine
Padmabhushana Chary Vemuluri, Sireesha Dodda
pp. s766–s771 · DOI: · Published 2023
Background: For the estimation of cabotegravir and rilpivirine in the bulk and pharmaceutical dosage form, a stability-indicating reverse-phase high-performance liquid chromatography method was developed and validated us…
Article
Marker Based Standardization of Quercetin in Marketed Capsules by Novel Zero Order Spectroscopic and Area Under Curve Spectroscopic Methods
Revati R. Surve, Harshal P. Tavanoji, Taufeeque R. Nadaf, Shweta C. Pote, Meenaxi M. Maste, Shailendra S. Suryawanshi
pp. s772–s786 · DOI: · Published 2023
Background: Quality control and standardization of phytomedicines play a vital role in herbal drug industries. Marker based quantification and standardization is one of the essential approaches used in quality evaluation…
Article
Different Innovative UV-spectroscopic Approaches for Simultaneous Assessment of Celecoxib and Tramadol Hydrochloride in Binary Mixture
Ashim Kumar Sen, Preksha Darji, Dhanya B. Sen, Aarti S. Zanwar, Chintan J. Aundhia, Rajesh A. Maheshwari
pp. s787–s797 · DOI: · Published 2023
Background and Aim: Tablets containing celecoxib and tramadol hydrochloride that are sold under the brand name Seglentis® have given approval by the “Food and Drug Administration” (FDA) for the treatment of adults suffer…
Article
Stability-Indicating Reversed Phase-HPLC Method Development and Validation for Estimation of Phenylephrine in Bulk and Tablet
Shruti Srivastava, Suneela Dhaneshwar, Neha Kawathekar
pp. s798–s804 · DOI: · Published 2023
Background: This study is aimed to develop a validated stability-indicating method of a nasal decongestant phenylephrine hydrochloride in bulk and tablet. Materials and Methods: A sensitive, accurate, and specific revers…
Article
Implementation of Analytical Quality by Design Methodology to Develop a UV-spectrometric Technique for Arteether Quantification
Neha Bajwa, Pallavi Saroch, Ashish Baldi
pp. s805–s813 · DOI: · Published 2023
Aim/Background: Analytical Quality by Design refers to applying the Quality by Design idea to the development of analytical procedures. The present study emphasizes the AQbD concept of developing and validating a spectro…
Article
Chemical Composition and Therapeutic Effects of Ammodicus leucotricus Essential Oils on Neurobehavioral Changes in Wistar Rats after Experimental Scorpion Envenomation
Ammam Abdelkader, Belmamoun Ahmed Reda, Chadli Redouane, Boudia Rafik, Benhafsa Mekhalef Fouad, Hafidh Zemour, Didier Villemin, Walid Soufan, Fathi Abdellatif Belhouadjeb
pp. s814–s820 · DOI: · Published 2023
Background: Our study consists of a study of the chemical composition of the essential oil administered to a batch of rats undergoing a scorpion sting. Compared with control batches, the nervous state was evaluated by se…
Article
Effects of Artemisinin on Anti-epileptogenic, Antioxidant and Cholinesterase Enzymes in Pentylenetetrazole-induced Kindling Model in Mice
Yilmaz Kocak, Oruc Yunusoglu, Zubeyir Huyut, Fikret Turkan
pp. s821–s830 · DOI: · Published 2023
Background: Artemisinin (ART) is a compound synthesized from the plant Artemisia annua. This compound has various therapeutic effects and is widely used against malaria. However, ART is known to have modulating effects o…