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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Chemical Composition and Therapeutic Effects of Ammodicus leucotricus Essential Oils on Neurobehavioral Changes in Wistar Rats after Experimental Scorpion Envenomation

Ammam Abdelkader1★, Belmamoun Ahmed Reda2, Chadli Redouane3, Boudia Rafik4, Benhafsa Mekhalef Fouad5, Hafidh Zemour6, Didier Villemin7, Walid Soufan8, Fathi Abdellatif Belhouadjeb9★ Corresponding author

  1. 1Laboratory of Pharmacognosy, Bio Toxicology and Biological Valorization of Plants, Moulay Tahar University, Saida, ALGERIA.
  2. 2Laboratory of Process, Materials and Environment Engineering, Djillali Liabes University, Sidi-Bel-Abbes, ALGERIA.
  3. 3Laboratory of Organic and Macromolecular Physical Chemistry, Djillali Liabes University, Sidi-Bel-Abbes, ALGERIA.
  4. 4Laboratory of Applied Organic Synthesis, University of Oran; ALGERIA.
  5. 5Centre de Recherche Scientifique et Technique en Analyses Physico-chimiques CRAPC, Bou-Ismail, Tipaza, ALGERIA.
  6. 6Faculty of Natural and Life Sciences, Ibn Khaldoun University, BP 14000, Tiaret, ALGERIA.
  7. 7University of Caen, ISMRA, LCMT, UMR CNRS 6507, Caen, F-14050, FRANCE.
  8. 8Plant Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, SAUDI ARABIA.
  9. 9Center of Research in Agropastoralisme (CRAPAST), Djelfa, ALGERIA.

CORRESPONDENCE

Ammam Abdelkader

Laboratory of Pharmacognosy, Bio Toxicology and Biological Valorization of Plants, Moulay Tahar University, BP 20000, Saida, ALGERIA.

vetokadi@yahoo.fr

Received: 16-02-2023; Revised: 05-05-2023; Accepted: 22-07-2023.

Volume 57, Issue 3S · pp. s814–s820 · PUBLISHED 2023 · DOI:

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ABSTRACT

Background: Our study consists of a study of the chemical composition of the essential oil administered to a batch of rats undergoing a scorpion sting. Compared with control batches, the nervous state was evaluated by several neurobehavioral tests, namely open classified, dark and light and forced swimming. Materials and Methods: Determination of the composition of the essential oil the plant by GC/MS and its protective effect on the nervous system after exposure of rats to scorpions. Results: of GC/MS show that the chemical composition of this plant is characterized by the dominance of the natural monoterpenoid agent Perilla aldehyde, with a percentage of 70.12%, followed by Limonene (10.10%), Methyleugenol (5.69%), and alpha-Pinene (5.04%). Other compounds such as Perilla alcohol (1.90%), Beta-Pinene (0.61%), Delta-3-Carene (0.59%), Carvone (0.44%) and Camphene (0.33%) were identified only in a small proportion. The series of tests allowed us to see the onset of a depressive state, as well as a significant decrease in locomotor activity in the bitten rats compared to the controls and the treated batch. This hypolocomotor effect is accompanied by a decrease in the animal’s stereotyped behaviours (curiosity, sniffing, biting, and grooming) and muscular tone, which explains the animal’s inability to explore the environment. Conclusion: The neuroprotective power study confirmed the powerful properties of the plant to improve the symptoms caused by the scorpion sting, as proven by several neurobehavioral tests.

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    Abdelkader, A., Reda, B. A., Redouane, C., Rafik, B., Fouad, B. M., Zemour, H., Villemin, D., Soufan, W., & Belhouadjeb, F. A. (2023). Chemical Composition and Therapeutic Effects of Ammodicus leucotricus Essential Oils on Neurobehavioral Changes in Wistar Rats after Experimental Scorpion Envenomation. Indian Journal of Pharmaceutical Education and Research, 57(3S), s814–s820.