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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats

Dhanaraju Kavitha1,2, Ramakrishnan Padmini1★, Magharla Dasaratha Dhanaraju2, Chandravadivelu Gopi2, Deepan Thiyagarajan2, Alekkhya Veeramaneni2★ Corresponding author

  1. 1Department of Biochemistry, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, INDIA.
  2. 2Department of Pharmaceutical Chemistry, GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, INDIA.

CORRESPONDENCE

Ramakrishnan Padmini

Department of Biochemistry, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai-600117, Tamil Nadu, INDIA.

padmini.sls@velsuniv.ac.in

Received: 27-09-2022; Revised: 20-03-2023; Accepted: 15-06-2023.

Volume 57, Issue 3S · pp. s690–s700 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.3s.78

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ABSTRACT

Background: Syringodium isoetifolium seagrass has bioactive constituents with potential pharmacological uses, but their use is limited. Materials and methods: Wistar albino rats were split into five groups. Except for group I, remaining all received DEN and Phenobarbitone. Extracts were administered to group III and IV orally with the dose of 250 and 500 mg/kg. 5 fluorouracil 20mg/kg was the standard. Results: The findings show that Syringodium isoetifolium significantly reduces liver tumor volume, burden and numbers in experimental rats (p less than 0.05). Besides, the extracts treated groups restored the pathological parameters close to normal values. Conclusion: The study concludes that Syringodium isoetifolium inhibits cancer growth by altering the antioxidant defense system, glycolysis and protecting membrane architecture.

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    Kavitha, D., Padmini, R., Dhanaraju, M. D., Gopi, C., Thiyagarajan, D., & Veeramaneni, A. (2023). Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats. Indian Journal of Pharmaceutical Education and Research, 57(3S), s690–s700. https://doi.org/10.5530/ijper.57.3s.78