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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats

Bixia Xu1★, Abdullah A. Alarfaj2, Abdurahman Hajinur Hirad2, Nandakumar Natarajan3, Petchi Iyappan4, Samer Hasan Hussein Al Ali5★ Corresponding author

  1. 1Teaching and Research Section of Internal Medicine, Zhaoqing Medical College, Guangdong Province, CHINA.
  2. 2Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, SAUDI ARABIA.
  3. 3Department of Cellular and Molecular Biology, University of Texas at Tyler Health Science Center, Tyler, TEXAS, USA.
  4. 4Faculty of Medicine, Bioscience and Nursing, Mahsa University, Saujana Putra, MALAYSIA.
  5. 5Department of Chemistry, Faculty of Science, Isra University, Amman, JORDAN.

CORRESPONDENCE

Bixia Xu

Teaching and Research Section of Internal Medicine, Zhaoqing Medical College, Zhaoqing City, Guangdong Province, 526020, CHINA.

surither@hotmail.com

Received: 01-01-2023; Revised: 01-04-2023; Accepted: 01-07-2023.

Volume 57, Issue 3S · pp. s701–s709 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.3s.79

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ABSTRACT

Background: Diabetes mellitus is among the most serious public health problems worldwide. Materials and Methods: 35mg/kg STZ was injected to rats for stimulating diabetes. Then rats were treated with 25mg/kg of brassinin. Results: Brassinin and Glibenclamide remarkably decreased glucose and HbA1c levels in diabetic rats, while insulin levels were elevated. They also increased antioxidant enzymes and decreased inflammatory markers. Conclusion: Brassinin is an antihyperglycemic, antioxidant, and anti-inflammatory compound that protects the liver, kidney, and pancreas during diabetes.

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    Xu, B., Alarfaj, A. A., Hirad, A. H., Natarajan, N., Iyappan, P., & Ali, S. H. H. A. (2023). Brassinin Exhibits Anti-Diabetic Activity against Streptozotocin-induced Diabetes Mellitus in Experimental Rats. Indian Journal of Pharmaceutical Education and Research, 57(3S), s701–s709. https://doi.org/10.5530/ijper.57.3s.79