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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

In vitro and in vivo Antidiabetic Activity of Ag Nanoparticles Mediated from Gymnemic Acid I and II

Navanita Sivaramakumar1, Kalakotla Shanker1★★ Corresponding author

  1. 1Department of Pharmacognosy, JSS College of Pharmacy, Ooty, Nilgiris, Tamil Nadu, INDIA.

CORRESPONDENCE

Kalakotla Shanker

Department of Pharmacognosy, JSS College of Pharmacy, Nilgiris, Tamil Nadu, INDIA.

shankerkalakotla@gmail.com

Received: 27-08-2022; Revised: 09-03-2023; Accepted: 08-06-2023.

Volume 57, Issue 3S · pp. s710–s717 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.3s.80

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ABSTRACT

Background: Gymnema sylvestre is traditionally used to treat diabetes in Asia. Materials and methods: GA-I and GA-II were docked to PTP 1B. Nanoparticles were produced using centrifugation green synthesis. Results: Blood glucose levels significantly decreased (p less than 0.001) at a dose of 200 mg/kg of GA-I mediated AgNPs. Conclusion: GA-I mediated AgNPs can be exploited as prospective nanomedicine for type-2 diabetes.

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    Sivaramakumar, N., & Shanker, K. (2023). In vitro and in vivo Antidiabetic Activity of Ag Nanoparticles Mediated from Gymnemic Acid I and II. Indian Journal of Pharmaceutical Education and Research, 57(3S), s710–s717. https://doi.org/10.5530/ijper.57.3s.80