Volume 57, Issue 4

1. Article

   Sustainable Antimicrobial Nanomaterials: A Promising Treatment for Multiple Drug Resistant Microorganisms

   Neha S. Raut, Ram Musle, Monika Raut, Rakesh M. Kanchhul, Ekant S. Taywade, Milind J. Umekar

   pp. 937–950 · DOI: 10.5530/ijper.57.4.115 · Published 2023

   : Antibacterial drugs had an essential role in the treatment of various diseases from a long-time whereas excess use leads to resistance and toxicity which is a great challenge in the health sector. The most important fa…

2. Article

   Role of Stem Cells in the Management of Type-I Diabetes Mellitus

   H. R. Arjun, Praveen Halagali, Y. Mohammed Tausi, N. Paramakrishnan, U. R. Rakshith

   pp. 951–955 · DOI: · Published 2023

   The paper aims to accent Type-1 DM along with its etiology, pathophysiology, and treatment in this review. Diabetes is considered the chronic ailment of hypoglycemia ensuing from the duo of the dearth of insulin action a…

3. Article

   Biotherapeutic Potential of Lactobacillus Probiotic Strains on Streptococcus mutans Biofilm in Dental Caries-Pathogenesis Revisited

   Vaishnavi Vedam, Sabesan Gokul Shankar, Arun Kumar Adhikary, Subramani Parasuraman

   pp. 956–964 · DOI: · Published 2023

   This review gives an insight on the anticariogenic role of each of the individual strains of Lactobacillus probiotics on Streptococcus mutans bacterium associated with dental caries and also attempts to emphasize the com…

4. Article

   Quality by Design based Quercetin Hydrate Nanoemulsions for Enhanced Solubility by Reducing Particle Size

   Lakavath Sunil Kumar, Hindustan Abdul Ahad

   pp. 965–970 · DOI: · Published 2023

   Aim/Background: The oral-based drug delivery system has a great pace in this era of novel discoveries. The globe is running toward new medical dosage forms, but from the primer days of drug discovery to now, a major issu…

5. Article

   Mucoadhesive Chitosan-Coated PLGA Nanoparticles of Ashwagandha Extract for Colon-Targeted Delivery

   Abhilash Megaravalli Manjunath, Sneh Priya, Divya Jyothi

   pp. 971–982 · DOI: · Published 2023

   Aim/Background: Withania somnifera (Ashwagandha) belongs to the Solanaceae family, well known for its phyto-pharmacological properties such as anti-inflammatory, antioxidant, anti-stress, immunomodulatory, and anticancer…

6. Article

   Central Composite Design Assisted Formulation Development and Optimization of Gastroretentive Floating Tablets of Dextromethorphan Hydrobromide

   Haranath Chinthaginjala, Hindustan Abdul Ahad, Sainath Kethandapatti Srinivasa, Srihith Roy Yaparla, Snehitha Buddadasari, Junaid Abul Hassan, Sai Sree Pullaganti

   pp. 983–992 · DOI: · Published 2023

   Objectives: The existing study is concerned with the formulation and optimization of dextromethorphan hydrobromide floating tablets via central composite design. Materials and Methods: Direct compression method was emplo…

7. Article

   Design, Development and Optimization of Buccal Tablet Containing Extract of Terminalia chebula Retz. for the Treatment of Asthma

   P. B. Suruse, M. B. Gawali, R. S. Kalkotwar, R. B. Bhabad, S. B. Bagdane, L. G. Barde

   pp. 993–1001 · DOI: · Published 2023

   Objectives: The aim of the study was to design, develop, and optimize the buccal tablets containing extract of Terminalia chebula Retz. for the treatment of asthma. Materials and Methods: Buccal tablets were made using t…

8. Article

   Ameliorating the Poor Dissolution Rate of Selexipag in Aqueous Acidic Conditions Following Confinement into Mesoporous Silica

   Mohamed S. Attia, Fakhr-Eldin S. Ghazy

   pp. 1002–1011 · DOI: · Published 2023

   Background: Pulmonary Arterial Hypertension (PAH) is a serious condition with available treatment options, including Selexipag (SXP), a selective prostacyclin receptor agonist that has effectively reduced patient morbidi…

9. Article

   Development, Evaluation, and in vitro Anti-Acne Activity of Tretinoin Nanocrystals Gel

   Pottathil Shinu, Akash Sharma, Anroop B. Nair, Manish Kumar, Shahzad Khan, Abdulaziz K. Al Mouslem, Mohamed A. Morsy, Abhishek Tiwari, Varsha Tiwari, Beena Kumari

   pp. 1012–1020 · DOI: · Published 2023

   Background: Tretinoin is generally used to treat acne vulgaris and photoaging. The study aimed to develop a gel composition containing tretinoin nanocrystals and characterize and compare in vitro anti-acne activity. Mate…

10. Article

    Formulation, Characterization, and Cytotoxic Effect of PVA Incorporated Iron Oxide Nanoparticles of Gramine Using HCT-116 Cell Line in vitro

    Ahmed S. Alnaim

    pp. 1021–1028 · DOI: · Published 2023

    Background and Objectives: Globally, Colorectal cancer is the major cause of death. The current work emphasizes the synthesis of Gramine-loaded polyvinyl alcohol (PVA) coated Iron Oxide nanoparticles (NPs) and the evalua…

11. Article

    Identifying Potential Drug Candidates against Plasmodium falciparum (Isolate 3D7) through Targeting ADP-dependent DNA Helicase RecQ: An in silico Approach

    Marya Ahsan, Ayaz Khurram Mallick

    pp. 1029–1036 · DOI: · Published 2023

    Background: The malarial scenario has significantly varied in the past few decades; whether it is funding or the range of sophisticated life-saving tools that have been improved, the disease burden has reduced, and even …

12. Article

    In vitro and in silico Protective Effects of Ascorbic Acid on Nicotine-treated Human Erythrocytes (Preliminary Studies)

    Ohoud Saeed S Alamri, Uzma Faridi

    pp. 1037–1043 · DOI: · Published 2023

    Objectives: Nicotine is one of the most addictive naturally occurring drugs and is commonly found in tobacco products. Tobacco products are one of the most common causes of lung and oral cancer all over the world. As the…

13. Article

    In silico Discovery of STRA 6 Vitamin A Receptor, as a Novel Binding Receptor of COVID-19

    Mahmoud Elkazzaz, Israa M. Shamkh

    pp. 1044–1052 · DOI: · Published 2023

    A global pandemic of pneumonia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, at the end of 2019. Although, the ACE2 receptor has been demonstrated to be the main entry …

14. Article

    Citrollenol Abrogates Neuroinflammatory Pathway Regulated via Induction of NF-kB in AlCl3 Induced Alzheimer’s Disease – Molecular Approach

    Xiaoli Zhou, Hesham S. Almoallim, Balasubramani Ravindran, Rui Qin

    pp. 1053–1060 · DOI: · Published 2023

    Background: Alzheimer's Disease (AD), a neurodegenerative disorder characterized by dementia, is linked to ROS-induced stress, neuroinflammation, and gut microbiota imbalance. Objectives: The antioxidant and anti-inflamm…

15. Article

    Neuroprotective Effect of Ruscogenin against Cognitive Impairment on Pentylenetetrazole-induced Epileptic Seizures in Rats

    Qiaoli Ma, Hesham S. Almoallim, Sulaiman Ali Alharbi, Thamaraiselvan Rengarajan

    pp. 1061–1070 · DOI: · Published 2023

    Background: Epilepsy, which affects about 1% of the world's population, is the third most common neurological disease after stroke and Alzheimer's disease. It is characterized by recurrent spontaneous seizures due to abn…

Original Article

1. Article

   Evaluation of the Aqueous Extract of Musa acuminata Corm (Rhizome) for its Anti-diabetic Potential in Streptozotocin (STZ) Induced Diabetic Zebrafish (Danio rerio) Model

   Yahia Ali Kaabi

   pp. 1071–1077 · DOI: 10.5530/ijper.57.4.129 · Published 2023

   Background Information: Diabetes Mellitus (DM) is spiking substantially in both emerging and developed countries and the use of a nutritional approach to diabetes control has recently attracted a lot of attention. The ba…

2. Article

   Influence of Extraction Techniques on Betalain Yield and Bioactive Phytochemical Analysis of Nopal Fruit Peels

   Anbarasi Karunanithi

   pp. 1078–1086 · DOI: 10.5530/ijper.57.4.130 · Published 2023

   Background: Nopal fruits (Opuntia ficus-indica) and their peels contain significant amount of natural colorants which can be used in food and pharmaceutical applications instead of using synthetic dyes. Materials and Met…

3. Article

   Palliative Action of Woodfordia fruticosa Leaves Containing Woodfruticosin on Biological Redox Imbalance and Anemia in CFA-Induced Arthritic Rats

   Ashish Singhai, Yusra Ahmad, Umesh Kumar Patil

   pp. 1087–1097 · DOI: 10.5530/ijper.57.4.131 · Published 2023

   Background: Rheumatoid Arthritis (RA) is a chronic disorder affecting musculoskeletal and autoimmune system with inflammatory characteristics. Anemia is most prevailing, among other extra-articular complications in RA. T…

4. Article

   Phytochemical Screening, Acute Toxicity Study, and Pharmacological Evaluation of Natsiatum herpeticum Buch.Ham. ex Arn.

   Sangeeta Hazarika, Siva Hemalatha, Katharigatta Narayanaswamy Venugopala

   pp. 1098–1103 · DOI: 10.5530/ijper.57.4.132 · Published 2023

   Background: Plants are an open treasure of diverse pharmacologically active scaffolds. Natsiatum herpeticum, a least exploited plant, is known to be consumed by various ethnic groups of Asian origin as edible or as part …

5. Article

   Evaluation of Sinapic Acid on STZ-induced Depression in Diabetic Wistar Rats

   Shubhangi Pawar, Sheetal Shinde, Ekta Khapare, Rishikesh Bacchav

   pp. 1104–1111 · DOI: 10.5530/ijper.57.4.133 · Published 2023

   Objectives: Presently, diabetes is a major chronic metabolic abnormality characterized by sustained hyperglycemia. Diabetic neuropathy, encephalopathy, diabetes induced anxiety, depression is common life-threatening comp…

6. Article

   Evaluation of Antioxidant and Oxidative Stress Activity of Carthamus tinctorius L. Extract in Lung Cancer A549 Cells

   Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Balasubramani Ravindran, Karunakaran Saravanan

   pp. 1112–1118 · DOI: 10.5530/ijper.57.4.134 · Published 2023

   Background: C. tinctorius (safflower) natural food colorant and has been used to control high blood pressure, supress oxidation, cancer immunosuppressive drug, inhibits blood clots, dilate blood vessels, and as neuroprot…

7. Article

   Synergistic and Toxicity-reducing Effects of Periplaneta americana Extract CⅡ-3 Combined with CTX on H22 Tumor Bearing Mice

   Rui Yuan, Guangming Liu, Meixian Guo, Xiaobo Liu

   pp. 1119–1131 · DOI: 10.5530/ijper.57.4.135 · Published 2023

   Background: Cyclophosphamide (CTX) is widely used in tumor treatment, but its clinical therapeutic effect is not ideal due to many side effects. Materials and Methods: In the present study, we researched the synergistic …

8. Article

   Inhibition of Phenylhydrazine-induced Hematotoxicity by Bioconverted Ginsenosides

   Yuseong Chung, Kang Min Kim, Jae Seon Kang

   pp. 1132–1139 · DOI: 10.5530/ijper.57.4.136 · Published 2023

   Aim: To identify the inhibition of Phenylhydrazine (PHZ)-induced hepatotoxicity and anemia by bioconverted ginsenosides. Materials and Methods: We examined the potential benefits of bioconverted ginsenosides on anemia in…

9. Article

   Evaluation of Anti-inflammatory Effects of Polysaccharide Derived from Plantago ovata Husk on Trinitro Benzenesulfonic Acid-induced Ulcerative Colitis in Mice

   Jiangtao Hu, Siying Wang

   pp. 1140–1149 · DOI: 10.5530/ijper.57.4.137 · Published 2023

   Background: Ulcerative colitis, an idiopathic, chronic inflammatory illness of the intestinal mucosa is primarily fuelled by inflammation and oxidative stress. Aim: The present study aimed to investigate the anti-inflamm…

10. Article

    Evaluation of Anti-Depressant Activity of spirulina, a blue-green algae on Chronic Unpredictable Stress Induced Depression in Rats

    Girish Meravanige Basavarajappa, Juturu Balaraju, Nimbagal Raghavendra Naveen, Prakash Goudanavar, Vakkalagadda Siva Ganesh, Sreeharsha Nagaraja, Predeepkumar Narayanappa Shiroorkar, Mallikarjun Telsang

    pp. 1150–1158 · DOI: 10.5530/ijper.57.4.113 · Published 2023

    Background: Depression is a crippling and pervasive illness that can affect a person in many different ways. It can be identified by certain symptoms, such as modifications in behaviour, psychological functioning, and br…

11. Article

    Study on the Synthesis and Hypolipidemic Activities of Coumarin Oxime Esters Derivatives

    Haoyun Chang, Guangyao Li, Peng Liu, Supei Hu, Peng Huang, Haixia Hu, Nongzhang Xu, Yang Zhou

    pp. 1159–1166 · DOI: 10.5530/ijper.57.4.138 · Published 2023

    Aim: The major objective of this research was to synthesize and evaluate the hypolipidemic Activities of Coumarin Oxime esters and develop the possible target. Materials and Methods: Using salicylaldehyde and ethyl aceto…

12. Article

    Artemetin, A Dietary Flavonoid Inhibits the Proliferation and Induces Apoptosis in Human Gastric Carcinoma (AGS) Cells

    Yuxing Lv, Yinquan Wang, Gaopeng Hao

    pp. 1167–1174 · DOI: 10.5530/ijper.57.4.139 · Published 2023

    Background: One of the most common types of recurrent carcinoma cases worldwide is gastric cancer. Even advances in treatment methods and early discoveries have not been able to significantly lower the death and morbidit…

13. Article

    Applying Hands-on Inquiry Learning in Physical Chemistry Teaching Practice to Improve Teaching Quality

    Xiaojun Deng, Jingfeng Zhao, Qinqin Tian, Haibo Wang

    pp. 1175–1182 · DOI: 10.5530/ijper.57.4.140 · Published 2023

    Background: Physical chemistry is an important theoretical basic course that supports the development of medicine and pharmacies. Physical chemistry teaching is usually a process of traditional teaching and passive accep…

14. Article

    Design and Application of the Blended Teaching Mode in the Curriculum of Pharmacokinetics

    Zhongbing Liu, Shuzao Wang, Yan Lin, Meiling Zhou, Pei Jing, Zhirong Zhong

    pp. 1183–1191 · DOI: 10.5530/ijper.57.4.141 · Published 2023

    Introduction: Pharmacokinetics is one of the main courses of pharmacy majors in medical colleges and universities. The course is highly practical involving multidisciplinary collaboration, with strong logical reasoning a…

15. Article

    Application of Multi-element Integrated Teaching in the Human Anatomy and Physiology Course in Pharmacy Majors

    Hong Zhang, Jinghua Xu, Wang Jiahong, Yanting Gu, Guoxiang Sun

    pp. 1192–1195 · DOI: 10.5530/ijper.57.4.142 · Published 2023

    Background: A professional foundational course in human anatomy and physiology is required of pharmacy students to establish their understanding of the field. Since it includes human anatomy and human physiology, two cru…

16. Article

    An Overview on Development, Approval and Post Registration Activities for Pharmaceuticals in European Union

    D Thanush, Balamuralidhara V, Thoyajaksha V, Deeksha K S, Gowthami K R

    pp. 1208–1218 · DOI: 10.5530/ijper.57.4.144 · Published 2023

    Background: Bringing a new medicine from concept to market is costly and complex. Years of study and development go into it. Product development operations should be carried out in line with applicable regulatory standar…

17. Article

    Analysis of ICH-Q3D Endorsed Elemental Impurities in Macrolide Antibiotics by ICP-MS

    Ravisankar Mathesan, Alexandar Sekar, Senthil Kumar Raju, Kumar Mohan, Venkateswarlu Bendi Sri

    pp. 1219–1225 · DOI: 10.5530/ijper.57.4.145 · Published 2023

    Aim: The objective of this study was to determine the amount of twenty-three elemental impurities in Azithromycin API. A rapid, selective, precise, accurate and sensitive approach for detecting elemental impurities in Az…

18. Article

    Interaction Studies of Moxifloxacin with Anti-diabetic Drugs and Application of RP-HPLC in Analysis

    Sania Bashir, Fatima Qamar, Safila Naveed, Syeda Zainab, Halima Sadia, Aisha Sana, Wajeeha Muzafar

    pp. 1226–1231 · DOI: 10.5530/ijper.57.4.146 · Published 2023

    Aim: Simple RP-HPLC method was developed and validated for the simultaneous estimation of Glimepiride, Glibenclamide and Moxifloxacin in pharmaceutical preparation. Materials and Methods: Mediterranean C18 column with di…

19. Article

    Assessment of the Suitability of the Delphi Method for Assessing the Needs of Pharmacoeconomic Studies in the Decision-Making Process

    Sabina Becirovic, Valentina Marinkovic, Dragana Lakic

    pp. 1232–1241 · DOI: 10.5530/ijper.57.4.147 · Published 2023

    Background: Increasing need for control in healthcare spendings and for publicly available services, opens new areas and topics that needs to be discussed. The aim of this paper is assessment of the technic adequacy for …

20. Article

    The Attitude, Knowledge, and Evaluation of Herbal Medicinal Products for Respiratory Diseases in Northern Cyprus among Pharmacists, Patients, and Pulmonologists

    Mehmet Dumenci, Filiz Mericli, Özgur Tosun, Dudu Özkum Yavuz

    pp. 1242–1250 · DOI: 10.5530/ijper.57.4.148 · Published 2023

    Background: The utilization of Complementary and Alternative Medicine (CAM) has grown remarkably over the years as people seek alternative treatment methods to conventional medicine to manage various health conditions. A…

21. Article

    Effect of a Herbal Formulation on Infection Prevention and Immune Regulation in Children with Frequent Relapse Nephrotic Syndrome

    Haiyun Wang, Binbin Tang, Junjie Shi, Yan Wang, Qili Wang

    pp. 1251–1257 · DOI: 10.5530/ijper.57.4.149 · Published 2023

    Objectives: This study aims to investigate the effect of a herbal formulation "Guyuan Tang" on preventing the recurrence of children with frequent relapse nephrotic syndrome and its influence on immune function. Material…

22. Article

    Formulation and Evaluation of Pluronic F-127 Assisted Carboplatin Cubosomes

    Jawaher Abdullah Alamoudi, Yosif Almoshari, Hadil Faris Alotaibi

    pp. 1258–1264 · DOI: 10.5530/ijper.57.4.150 · Published 2023

    Objectives: The objective of this study was to prepare carboplatin loaded cubosomes using high sheer homogenization technique. Materials and Methods: The cubosomes were prepared using Glyceryl Monooleate (GMO) as a lipop…