Volume 58, Issue 1

2024 · pp. 1–368 · 40 articles

Volume: 58
Issue: 1
Published: 2024
Pages: 1–368
Articles: 40
Sections: 3
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article Corrigendum

In this issue

Review Article

Review
The Traditional Uses, Phytochemistry, and Pharmacological Effects of Clitoria ternatea: A Review
Kamran Ashraf, Nur Fatin Adlin, Aina Nabila Basri, Wasim Ahmad, Sadia Sultan
pp. 1–14 · DOI: 10.5530/ijper.58.1.1 · Published 2024
Clitoria ternatea (Family: Fabaceae) is an important medicinal plant in traditional folk medicine. This plant was found to contain various types of metabolites. Many different pharmacological effects, including antioxida…
Review
Enlightening Pharmacological Mechanisms of Cannabidiol in Epilepsy: A Comprehensive Review on their Neuroprotective Potential
Aman Shrivastava, Jeetendra Kumar Gupta
pp. 15–20 · DOI: 10.5530/ijper.58.1.2 · Published 2024
Cannabinoids interact with Cannabinoid Receptors (CBRs) and some related non-cannabinoid transcription factors within neurological and non-neuronal-specific receptors. The current review has covered pharmacological molec…
Review
Nanostructured Lipid Carriers: A Potential Era of Drug Delivery Systems
Haranath Chinthaginjala, Varalakshmi Bogavalli, Abdul Ahad Hindustan, Jayasree Pathakamuri, Sai Sree Pullaganti, Aswini Gowni, Bandhavi Baktha
pp. 21–33 · DOI: 10.5530/ijper.58.1.3 · Published 2024
Nanotechnology is rapidly evolving in the development of new drug delivery systems. Nanostructured lipid carriers are the second era of Solid Lipid Nanoparticles (SLN). These are the alternative carrier system over the s…
Review
Liposomal Cosmeceuticals as Skin Protectives and Curatives
Kajal Barge, Shivali Tank, Bhagyashri Parab, Mangal Nagarsenker, Supriya Shidhaye
pp. 34–44 · DOI: 10.5530/ijper.58.1.4 · Published 2024
Lifestyles and environmental changes draw people away from healthy and natural-looking skin. To hide the impaired and damaged skin texture as a result of several factors, people mostly prefer decorative cosmetics to get …
Review
A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospective
Suraj Mandal, Km. Bhumika, Mukesh Kumar, Jiyaul Hak, Prabhakar Vishvakarma, Umesh Kumar Sharma
pp. 45–63 · DOI: 10.5530/ijper.58.1.5 · Published 2024
Microsponges are porous microspheres ranging in size from 5 to 300 micrometers used in a polymeric delivery system. They have been studied for biomedical applications, including targeted medicine delivery, transdermal dr…
Review
Research Progress of Baicalin Interactions with the Animal Gut Microbiome
Peirong Chen, Bingjie Ma, Jinni Liu, Min Zhang, Jinzhe Li, Haigang Wu
pp. 64–68 · DOI: 10.5530/ijper.58.1.6 · Published 2024
Homeostasis of the animal gut microbiome is essential for maintaining intestinal health and normal growth and development. Baicalin is an O-glucuronidated flavonoid that possesses strong anti-bacterial, anti-inflammatory…

Original Article

Article
Assessment of the Quality of Education Received by Undergraduate Pharmacy Students in Selected Universities in Nigeria
Omotejohwo Emily Okolosi-Patani, Ufuoma David Adje, John Ejophe Arute, Ufuoma Shalom Ahwinawhi
pp. 69–75 · DOI: 10.5530/ijper.58.1.7 · Published 2024
Background: To assess the self-reported quality of education received by undergraduate pharmacy students and to explore factors influencing career choice. Materials and Methods: A pretested questionnaire was administered…
Article
Design and Characterization of pH Dependent Phase Transition System of Almotriptan Malate for Nasal Drug Delivery System by Employing Factorial Design
Vedanshu Malviya, Srikant Pande
pp. 76–90 · DOI: 10.5530/ijper.58.1.8 · Published 2024
Introduction: Nasal medication delivery uses nasal mucosa for faster and higher drug absorption. Transmucosal nasal administration is promising. Many medicines obtain superior systemic absorption via nasal route than ora…
Article
Fabrication and Evaluation of Poloxamer Facilitated, Glyceryl Monooleate based 5-Fluorouracil Cubosomes
Jawaher Abdullah Alamoudi, Yosif Almoshari, Hadil Faris Alotaibi
pp. 91–98 · DOI: 10.5530/ijper.58.1.9 · Published 2024
Objectives: This study aims to prepare a topical cubosomal formulation that contains 5-Fluorouracil (5-FU), a hydrophilic anti-cancer drug, that belongs to the Biopharmaceutics Classification System (BCS-III) i.e., high …
Article
Formulation, Optimization and Characterization of PLGA-Chitosan Nanoparticles Containing Vinorelbine Ditartrate
Varsha Bandil, Jeetendra Kumar Gupta, Manoj Kumar Goyal
pp. 99–108 · DOI: 10.5530/ijper.58.1.10 · Published 2024
Background: The prime objective of our investigation was to optimize PLGA-chitosan nanoparticles containing vinorelbine ditartrate. Materials and Methods: The Vinorelbine ditartrate nanoparticles were formulated using em…
Article
Ursolic Acid Loaded Transniosomes Nanogel for Topical Delivery: Statistical Optimization with Box-Behnken Design of Quality by Design (QbD), in vitro and Dermatokinetic Evaluation
Hafiz A. Makeen, Mohammad Albratty
pp. 109–121 · DOI: 10.5530/ijper.58.1.11 · Published 2024
Aim: The current research was performed for the preparation and optimization of Transniosomes (TN) preparation for the dermic distribution of Ursolic Acid (UA). Materials and Methods: The formulation was optimized by usi…
Article
Self-Nanoemulsifying Isotretinoin Topical Formulation: Development, Optimization and Characterization, in vitro Permeation Study by Using Response Surface Methodology
Sandeep Ghangas, Praveen Kumar Ashok, Tanuj Hooda
pp. 122–130 · DOI: 10.5530/ijper.58.1.12 · Published 2024
Aim/Background: The objective of this research was to develop a nano-emulsified formulation by using a central composite design for topical drug delivery. Materials and Methods: Isotretinoin-loaded nano-emulsified drug d…
Article
Design and Development of Anti-fungal Topical Gel Loaded with Solid Lipid Nanoparticles for Wound Healing
Girish Meravanige, Ranjitha B, Prakash Goudanavar, GSN Koteswara Rao, B Nirmala Devi, N. Raghavendra Naveen, Afzal Haq Asif, Sree Harsha Nagaraja, Mohammed Monirul Islam, Pavan Kumar Pavagada Sreenivasalu, Mallikarjun Telsang, Krishna Swaroop Duddi Sreehari
pp. 131–138 · DOI: 10.5530/ijper.58.1.13 · Published 2024
Background: The topical administration of antifungal drugs by Solid Lipid Nanoparticles (SLNs) has enormous potential. This study aimed to develop a topical 5-flucytosine-loaded SLNs gel to improve the efficacy of the we…
Article
Silver Nanoparticles Incorporated Chitosan Hydrogel as a Potential Dressing Material for Diabetic Wound Healing in Nursing Care
Ying Zhao, Qinqin Sun
pp. 139–144 · DOI: 10.5530/ijper.58.1.14 · Published 2024
Background: Nursing care of diabetic wounds remains a significant challenge due to a variety of reasons including low blood flow, impaired activity of inflammatory responses, and high oxidative stress in the diabetic wou…
Article
Chrysanthemum coronarium L: Chemical Composition and Gastroprotective Potential of Methanolic Leaf Extract in Ethanol-induced Gastric Ulcers in Male Wistar Rats
Ahmed Reda Belmamoun, Abdelkader Ammam, Chafik Mhamdia, Redouane Chadli, Afaf Baki, Abdenacer Tou, Hafidh Zemour, Didier Villemin, Walid Soufan, Fathi Abdellatif Belhouadjeb
pp. 145–153 · DOI: 10.5530/ijper.58.1.15 · Published 2024
Background: Our study evaluated the effect of Chrysanthemum coronarium L. (CC) leaves on ethanol-induced acute gastric ulcers in Wistar rats. Materials and Methods: The organic extract of CC was obtained by Soxhlet extra…
Article
Anti-Cancer Potential of Sinensetin, a Bioactive Compound against Human Cervical Carcinoma Cells via its Molecular Mechanism of Apoptosis
Abdulaziz S. Alothaim
pp. 154–161 · DOI: 10.5530/ijper.58.1.16 · Published 2024
Background: Cancer is ranked among the world's leading causes of death in 2020 with an estimated 10 million recorded fatalities attributable to the disease. After breast, colorectal, and lung cancer, cervical cancer is t…
Article
Anti-Asthmatic and Immunomodulatory Effect of Actinidia deliciosa Fruit on Swiss Albino Mice
Sanjita Das, Saumya Das, Sakshi Pal
pp. 162–171 · DOI: 10.5530/ijper.58.1.17 · Published 2024
Aim: The aim of the current research is the evaluation of immunomodulatory and anti-asthmatic activity of Actinidia deliciosa on Swiss albino mice by using a number of experimental models. Materials and Methods: The immu…
Article
Amelioration of Lipid Metabolic Profiles by Trigonelline a Bioactive Compound of Trigonella Foenum-graecum in Alcohol Induced Albino Rats
Meesala Guru Sekhar, Kondeti Ramudu Shanmugam, Kanchi Siva Prasad, Ramakrishna Chilakala
pp. 172–177 · DOI: 10.5530/ijper.58.1.18 · Published 2024
Aim: Alcoholism leads to heart diseases, lung diseases and liver disorders. Alcoholism impairs heart homeostasis and causes cardio vascular diseases. The current investigation was carried out to know the hypolipidemic ef…
Article
Identification of Suitable Amalgamation with Resveratrol, Epigallocatechin-3-gallate, and Diallyl Trisulfide against Skin Cancer Cell Lines (A431)
Gobika Arumugam, Sangilimuthu Alagar Yadav
pp. 178–186 · DOI: 10.5530/ijper.58.1.19 · Published 2024
Introduction: Resveratrol, Epigallocatechin -3-gallate (EGCG) and Diallyl Trisulfide (DATS) are bioactive compounds in which two polyphenols and an organosulfur are naturally occurring bioactive chemicals that can be eff…
Article
Histopathological and Biochemical Investigation of the Effect of Shepherd's Purse (Capsella bursa-pastoris L.) on Ethanol-Induced Liver Damage
Orhan Polat, Turan Yaman, Ahmet Ufuk Kömüroğlu
pp. 198–203 · DOI: 10.5530/ijper.58.1.21 · Published 2024
Background: The aim of the present study was to investigate the hepatoprotective effect of Shepherd's Purse (SP) herbal tea on ethanol (EtOH)-induced liver toxicity. Materials and Methods: Male Wistar rats (n = 32) were …
Article
Effect of Uzarin Isolated from Calotropis procera on Blood Electrolytes and Cardiac Related Enzymes
Nagy Morsy
pp. 204–211 · DOI: 10.5530/ijper.58.1.22 · Published 2024
Background: Cardiac glycosides are known to be one of the most important drugs that extracted from medicinal plants. Cardiac glycosides have been used as a medicine for a long time with congestive heart failure. Objectiv…
Article
The Hyperglycemic and Anti-hyperlipidemic Properties of Honeybee Mixed with Wheat Germ in Streptozotocin-induced Diabetes in Rats
Nawal Abbas Tahoon, Rania Adel Eid, Saad Aziz Mahgoub, Mohamed Saleh Ismail
pp. 212–219 · DOI: 10.5530/ijper.58.1.23 · Published 2024
Aim: This study aimed to find out the impacts of a honeybee and Wheat Germ (WG) combination on blood glucose and cholesterol concentrations in diabetic rats when administered orally. Materials and Methods: Thirty-eight m…
Article
Histopathological Changes in Animal Models by Catheters Coated with Saudi Medicinal Herb Evolvulus alsinoides L. Extract in Urinary Tract Infections by Klebsiella pneumoniae
Abubucker Peer Mohideen, Mohammed H. Karrar Alsharif, Muhammad Musthafa Poyil
pp. 220–230 · DOI: 10.5530/ijper.58.1.24 · Published 2024
Background: Catheter-Associated Urinary Tract Infections (CA-UTIs) pose a significant danger especially when they are caused by multi-drug resistant strains of Klebsiella pneumoniae. As elsewhere in the world, Saudi Arab…
Article
Nigella sativa Averts 5-Fluorouracil Induced Kidney Injury via Targeting Redox Imbalance and MAPK Pathway
Khalid M Alharthy, Summya Rashid
pp. 231–239 · DOI: 10.5530/ijper.58.1.25 · Published 2024
Introduction: Chemotherapy-induced organ toxicities are the most frequent toxic manifestation of 5-fluorouracil (5-Fu) action in cancer patients. Hence, new approaches are required to deter chemotherapy-induced kidney to…
Article
Investigation of the Pro-active Role of Alpha Amyrin Nanoemulsions in Quashing Neurodegeneration, Excitotoxicity, and Neuronal Inflammation-A Combined in vivo and in silico Approach
Ratna Baburaj, Rajendra Sandur V, Kuntal Das
pp. 240–253 · DOI: 10.5530/ijper.58.1.26 · Published 2024
Background: Aluminium is a pervading metal that poses a serious threat causing severe brain damage and neuro-degeneration. Alpha amyrin a pentacyclic triterpene despite its potency has not been properly utilized to treat…
Article
Molecular Mechanism of Apoptotic Cell Death in Cyanidin-3-glucoside-induced Cytotoxic Potential on Human Liver Carcinoma (HepG2) Cell Line
Suresh Mickymaray
pp. 254–262 · DOI: 10.5530/ijper.58.1.27 · Published 2024
Background: Liver cancer is one of the most prevalent cancers around the world and the leading cause of cancer-related deaths. Because liver cancer prevalence has increased significantly, there are no established therapi…
Article
Troxerutin Exerts Anti-Pulmonary Fibrosis Activity in Nicotine-Induced Lung Fibrosis on Zebra Fish Model
Yahya Hasan Hobani
pp. 263–270 · DOI: 10.5530/ijper.58.1.28 · Published 2024
Background: Cigarette smoking is the major obstacles to lung cell proteostatic imbalance due to the exposure of the respiratory epithelial cell to toxic oxidants. The most active ingredient presents in the cigarette smok…
Article
Uvaol Inhibits Inflammatory Response and Prevents Lipopolysaccharide-Induced Acute Lung Injury in Mice
Yubo Shi, Airu Wang, Hua Jiang
pp. 271–279 · DOI: 10.5530/ijper.58.1.29 · Published 2024
Background: Sepsis is a clinical disease characterized by systemic inflammatory reactions following infection that can lead to multiorgan failure. Acute Lung Injury (ALI) is a common ailment with increased morbidity and …
Article
Protective Effects of Hibiscetin on Ethanol-Induced Ulcers in Rats through Inhibition of Prostaglandin Synthesis/ Oxidative Stress/Caspase-3 and 9 Pathways
Faisal Alotaibi
pp. 280–290 · DOI: 10.5530/ijper.58.1.30 · Published 2024
Aim/Background: Ethanol (EtOH)-induced gastric ulcers are a prevalent gastrointestinal disorder characterized by severe inflammation, oxidative stress, and apoptotic cell death. This study aimed to investigate the potent…
Article
Spectrophotometric Absorption Correction Methods for the Estimation of Fixed-Dose Combinations of Dapagliflozin and Metformin Hydrochloride
Deepak Dalal, Ravi Kant, Kavita Attri, Kiran Sharma, Meenakshi Dhanawat
pp. 291–296 · DOI: 10.5530/ijper.58.1.31 · Published 2024
Background: For the assessment of fixed-dose combinations of Dapagliflozin and Metformin Hydrochloride in bulk pharmaceuticals and pharmaceutical formulations utilizing distilled water as a solvent, a novel, straightforw…
Article
Stability Indicating Method Development and Validation for the Simultaneous Estimation of Azilsartan and Chlorthalidone in their Bulk and Pharmaceutical Dosage Forms by RP-UPLC
Upender Rao Eslawath, Kannappan N, Venkateshwarlu L, Anton Smith A
pp. 297–304 · DOI: 10.5530/ijper.58.1.32 · Published 2024
Aim: The present study is aimed towards developing and validating novel RP-UPLC analytical method for the analysis of Azilsartan and Chlorthalidone in their pharmaceutical formulations and to carry out stability studies …
Article
UV-spectrophotometric Method Development and Validation for Piperine Estimation in Black Pepper, Ayurvedic Formulation and Novel Nano Formulation: A Perfect Quality Assessment Tool
Akshay Kalgonda Patil, Sunil Satyappa Jalalpure, Supriya Suresh Chimagave, Bhaskar Kallappa Kurangi
pp. 305–315 · DOI: 10.5530/ijper.58.1.33 · Published 2024
Aim: The current study aims to establish and validate a UV-spectrophotometric approach for estimating piperine in black pepper, commercial Ayurvedic preparation, and novel piperine-loaded nanoformulation. Materials and M…
Article
Evaluation of the Knowledge, Attitude and Public Awareness about the Use of Antibiotics and Antibiotic Resistance in Albania
Eni Bushi, Zehadin Gashi, Ledjan Malaj
pp. 316–325 · DOI: 10.5530/ijper.58.1.34 · Published 2024
Aim: Antibiotic-Resistance remains a major risk to the general public's health. To assess public awareness about antibiotics usage and antibiotic resistance, survey-based research was conducted during October-December 20…
Article
Assessment of Health-Related Quality of Life and Associated Factors among Type 2 Diabetes Mellitus Patients Attending a Tertiary Care Hospital
Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Bharati Kangrali
pp. 326–332 · DOI: 10.5530/ijper.58.1.35 · Published 2024
Background: Type 2 diabetes mellitus is a chronic disease that can affect the quality of life of individuals. Health-Related Quality of Life (HRQOL) is an important outcome measure in assessing the impact of diabetes on …
Article
Risk of Respiratory Diseases with Use of Psychotropic Drugs: Results of a Community-based Cross-sectional Study from South India
Abhirami Eby, Raman Dang, Elsa Jacob
pp. 333–341 · DOI: 10.5530/ijper.58.1.36 · Published 2024
Background: The study evaluated the effect of various psychotropics on pulmonary function to identify the psychotropic drug class most commonly associated with risk of respiratory disorders. Since psychotropic medication…
Article
A Questionnaire-Based Study on the Use of Weight-Loss Medicines and Herbal Mixtures among Pharmacy Students in the Hail Region
Weiam Abdul Raheem Hussein, Mohammed Khaled Bin Break, Ahmed Alafnan, Bader Huwaimel, Weam Mohamed Ali Khojali, Nasrin Eldirdiri Khalifa, Naila Hassan Alkefai, Mhdia Elhadi Osman, Ghaliah Alshammari, Tahani S. Albalawi, Zahwah Alshammari, Haya Almutairi, Reem Alrasheedi, Talal Ahmed Alshammari, Ibrahim Khalid Alhajaji, Fawaz Alheibshy
pp. 342–347 · DOI: 10.5530/ijper.58.1.37 · Published 2024
Objectives: The obesity epidemic continues to grow at an alarming rate because the lifestyle we live plays a big role in the continuation and exacerbation of this problem. The use of medicines and herbs has become widesp…
Article
The Comparative Analysis of the Impact of N-Acetyl-L-Cysteine and its Combination with Propolis on Quality-of-Life in Patients with Acute Bronchitis
Ivana Tadić, Olivera Žuža, Dejan Žujović, Anita Agić, Davor Korčok, Biljana Lazović, Dejan Stevanović, Brižita Đorđević
pp. 348–354 · DOI: 10.5530/ijper.58.1.38 · Published 2024
Objectives: Evidence suggests that both N-Acetyl-L-cysteine (NAC) and NAC in combination with propolis (NAC-P) reduce symptoms of acute bronchitis and improve Health-Related Quality of Life (HRQoL). This study aimed to c…
Article
A Case Report of Retracted Publications in Pharmaceutical Science as a Remedy for Research Malpractice
Eric Wei Chiang Chan
pp. 364–368 · DOI: 10.5530/ijper.58.1.40 · Published 2024
Background: The number of retractions of journal articles has sharply increased in recent decades. Objectives: In this case report, excessive retracted publications on the anti-cancer properties of physcion 8-O-β-D-gluco…
Article
Anti-snakevenom Activity of Mesua ferrea Linn. against the Venom of Saw Scaled Viper (Echis carinatus)
B. Sivakumar, K. Koumaraveloue
pp. · DOI: 10.5530/ijper.58.1.20 · Published 2024
Background: Traditionally Mesua ferrea Linn. used in ethnomedicine for the treatment of various diseases, The leaves and flower are uses as antidote for snake poisoning. The anti-snakevenom activity has not yet reported …

Corrigendum

Article
Corrigendum: Enhanced Solubility of Meloxicam with Sodium Benzoate Hydrotrope: Ecofriendly Approach for Improved Topical Drug Delivery
Devika Tripathi, Dinesh Kumar Sharma, Jagannath Sahoo, Sunil Kumar Raman
pp. · DOI: · Published 2024
REFERENCE1. Tripathi D, Sharma DK, Sahoo J, Raman SK. Enhanced Solubility of Meloxicam with Sodium Benzoate Hydrotrope: Ecofriendly Approach for Improved Topical Drug Delivery. Indian J of Pharmaceutical Education and Re…