A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospective
Suraj Mandal1★, Km. Bhumika1, Mukesh Kumar1, Jiyaul Hak1, Prabhakar Vishvakarma1, Umesh Kumar Sharma1★ Corresponding author
- 1Department of Pharmacy, IIMT College of Medical Sciences, IIMT University, O-Pocket, Ganga Nagar, Meerut, Uttar Pradesh, INDIA.
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Suraj Mandal
Department of Pharmacy, IIMT College of Medical Sciences, IIMT University, O-Pocket, Ganga Nagar, Meerut, Uttar Pradesh, INDIA.
Received: 18-04-2023; Revised: 28-06-2023; Accepted: 14-08-2023.
Volume 58, Issue 1 · pp. 45–63 · PUBLISHED 2024 · DOI: 10.5530/ijper.58.1.5
ABSTRACT
Microsponges are porous microspheres ranging in size from 5 to 300 micrometers used in a polymeric delivery system. They have been studied for biomedical applications, including targeted medicine delivery, transdermal drug delivery, anticancer drug delivery, and bone substitutes. This research aims to conduct a detailed examination of existing trends and future prospects for a microsponge-based medicine delivery system. The current study investigates the Microsponge Delivery System's design, operation, and possible therapeutic uses (MDS). The therapeutic potential of microsponge-based formulations, as well as patent data, were thoroughly investigated. The authors discuss several efficient methods for producing microsponges, including liquid-liquid suspension polymerization, quasi-emulsion solvent diffusion, water-in-oil-in-water (w/o/w) emulsion solvent diffusion, oil-in-oil emulsion solvent diffusion, the lyophilization method, the porogen addition method, the vibrating orifice aerosol generator method, the electrohydrodynamic atomization method, and the ultrasound-assisted microsponge. Microsponge may reduce undesired side effects and increase drug stability by boosting drug release. Hydrophilic and hydrophobic drugs can be loaded into a microsponge and transported to a specific target. When compared to traditional distribution methods, microsponge delivery technology offers numerous advantages. Microsponges, which are spherical, sponge-like nanoparticles with porous surfaces, can help increase drug stability. They efficiently alter drug release while also reducing adverse effects
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Mandal, S., Bhumika, K., Kumar, M., Hak, J., Vishvakarma, P., & Sharma, U. K. (2024). A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospective. Indian Journal of Pharmaceutical Education and Research, 58(1), 45–63. https://doi.org/10.5530/ijper.58.1.5