Research Progress of Baicalin Interactions with the Animal Gut Microbiome
Peirong Chen1, Bingjie Ma1, Jinni Liu1, Min Zhang1, Jinzhe Li1★, Haigang Wu1,2★★ Corresponding author
- 1Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang, PEOPLE’S REPUBLIC OF CHINA.
- 2Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Medicine, Huazhong Agricultural University, Wuhan, PEOPLE’S REPUBLIC OF CHINA.
CORRESPONDENCE
Jinzhe Li
Laboratory of Veterinary Pharmacology and Toxicology, College of Animal Science and Veterinary Medicine, Xinyang Agriculture and Forestry University, Xinyang, PEOPLE’S REPUBLIC OF CHINA.
Received: 11-02-2023; Revised: 17-05-2023; Accepted: 20-08-2023.
Volume 58, Issue 1 · pp. 64–68 · PUBLISHED 2024 · DOI: 10.5530/ijper.58.1.6
ABSTRACT
Homeostasis of the animal gut microbiome is essential for maintaining intestinal health and normal growth and development. Baicalin is an O-glucuronidated flavonoid that possesses strong anti-bacterial, anti-inflammatory and antioxidant activities. Its addition to animal feed can alter gut microbial community composition, diversity and production of bacterial metabolites while decreasing production of pro-inflammatory cytokines and other factors that compromise the integrity of the epithelial cell barrier. This review thus summarizes the research progress of baicalin and regulation of the gut microbiota to provide guidance for the potential application of this compound for animal production as an antibiotic alternative.
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Chen, P., Ma, B., Liu, J., Zhang, M., Li, J., & Wu, H. (2024). Research Progress of Baicalin Interactions with the Animal Gut Microbiome. Indian Journal of Pharmaceutical Education and Research, 58(1), 64–68. https://doi.org/10.5530/ijper.58.1.6