jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Nigella sativa Averts 5-Fluorouracil Induced Kidney Injury via Targeting Redox Imbalance and MAPK Pathway

Khalid M Alharthy1, Summya Rashid1★★ Corresponding author

  1. 1Department of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, SAUDI ARABIA.

CORRESPONDENCE

Summya Rashid

Department of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, SAUDI ARABIA.

frenlysara@gmail.com

Received: 24-12-2022; Revised: 14-03-2023; Accepted: 08-06-2023.

Volume 58, Issue 1 · pp. 231–239 · PUBLISHED 2024 · DOI: 10.5530/ijper.58.1.25

View on IJPER original site ↗

ABSTRACT

Introduction: Chemotherapy-induced organ toxicities are the most frequent toxic manifestation of 5-fluorouracil (5-Fu) action in cancer patients. Hence, new approaches are required to deter chemotherapy-induced kidney toxicity. Nigella sativa (NS) is recognized as black cumin and has been found to be antiapoptotic, antioxidant, antimicrobial, anti-inflammatory and mitigates renal damage. Objectives: Thus, designed this work to evaluate the effect of NS in averting Nephrotoxicity induced by 5-FU treatment. Materials and Methods: Male albino Wistar rats were grouped and administered with saline, 5-FU group (150 mg/kg), 5-FU+NS (200 mg/kg) and 5-FU+NS (400 mg/kg), respectively. Rats were sacrificed on the 21st day, and biochemical, histological, serological and molecular estimations were done with kidney tissues and blood. 5-FU caused kidney injury as demonstrated by variations in kidney function markers (BUN, Cr, Kim-1), lipid peroxidation, histology and diminution of antioxidant guard machinery (GSH, GR, GPx and CAT). Additionally, 5-FU action changed p38 MAPK pathway proteins (p-p38, pJNK, pERK1/2, pNFkB, TNF-α) significantly. Conclusion: NS may serve as a potential candidate against renal injury by mitigating redox signaling, inflammation and p38 MAPK pathway. Therefore, NS could be used in adjuvant therapy for the prevention of Nephrotoxicity in cancer patients caused by 5-FU.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Alharthy, K. M., & Rashid, S. (2024). Nigella sativa Averts 5-Fluorouracil Induced Kidney Injury via Targeting Redox Imbalance and MAPK Pathway. Indian Journal of Pharmaceutical Education and Research, 58(1), 231–239. https://doi.org/10.5530/ijper.58.1.25