Volume 58, Issue 1S

2024 · pp. s306–s315 · 35 articles

Volume: 58
Issue: 1S
Published: 2024
Pages: s306–s315
Articles: 35
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
Quality Concerns of Lip Care Cosmetics and Applicable Regulatory Framework: Need for a Harmonized Cosmetovigilance Programme
Saurabh Dahiya, Rokshi Rokshi, Yachika Goyal, Chanchal Sharma
pp. s1–s8 · DOI: 10.5530/ijper.58.1s.1 · Published 2024
Cosmetics still have a glitzy attraction, but the public is increasingly concerned about their toxicity. Since 2500 BC, one way of enhancing the beauty of lips has been using lipstick compositions. Lip care cosmetic prod…
Review
Role of Social Media for Drug Safety Signal Detection
Kunjbihari Sulakhiya, Sushim Kanchan, Haroon Ansari, Anglina Kisku
pp. s9–s25 · DOI: 10.5530/ijper.58.1s.2 · Published 2024
Drug safety is an important factor considered during the drug discovery and development stages to develop safe and efficacious medicines for patients. Post-marketing surveillance is the commonly used method to obtain Adv…
Review
Heterocyclic Compounds and their Derivatives with Potential Anticancer Activity
Avneet Kaur, Ashok K. Shakya, Rohit Singh, Reena Badhwar, Shalini Kapoor Sawhney
pp. s26–s39 · DOI: 10.5530/ijper.58.1s.3 · Published 2024
Cancer is the second leading cause of the death worldwide. As per the reports published by WHO, the cases of cancer in the world will increase to 22 million by 2030. Many resources are investigated all around the world f…
Review
Insight into the Regulation of Nrf2/Keap 1 Pathway by Flavonoids as an Approach for Treatment of Liver Diseases: A Review
Ruchi Sharma, Chandana Majee, Rupa Mazumder, Swarupanjali Padhi, Fahad Khan, Rashmi Saxena Pal
pp. s40–s57 · DOI: 10.5530/ijper.58.1s.4 · Published 2024
Around 10% of the world’s population suffers from liver disease, making it one of the deadliest diseases in the world. Flavonoids are a class of phenolic substituents present in a wide range of vegetables and fruit and h…
Review
Molecular Insights into Salicylate Synthase: From Medicinal Chemistry Perspective
Nitin Bire, Vinayak Walhekar, Omkar Makane, Pranali Yelchatwar, Amol Muthal, Subhash Bodhankar, Chandrakant Bagul, Dileep Kumar, Baswaraju Macha, Raghavendra Kulkarni, Vaibhav Shinde, Ravindra Kulkarni
pp. s58–s66 · DOI: 10.5530/ijper.58.1s.5 · Published 2024
Tuberculosis is a pathogenic infection that has created trepidation around the globe due to its repercussion on the health of patients. The iron transport mechanism in mycobacterium plays a pivotal role in bacterial surv…

Original Article

Article
Synthesis and Bioactive Investigation of Amino Acids Fused 1,3,4-Oxadiazole Derivatives as Unnatural Amino Acids
Ajay Singh Bisht, Divya Juyal
pp. s67–s72 · DOI: 10.5530/ijper.58.1s.6 · Published 2024
Background: In present study 1,3,4-oxadiazole was attempted to synthesize from nicotinic acid and further their amino acid derivates were formed. Amino acids play a significant role in biological system. Only 20 amino ac…
Article
Chemical and Pharmacological Assessment of Substituted 1,2,4-Triazole Fused Pyrimidines as Anti-microbial Agent
Prafulla Sabale, Lata Potey, Suchita Waghmare, Nusrat Sayyad, Vidya Sabale
pp. s73–s79 · DOI: 10.5530/ijper.58.1s.7 · Published 2024
Objectives: To synthesize a novel series of 3-(Aryl/Heteroaryl)-5-Methyl-7-Phenyl [1,2,4]triazolo[4,3a]Pyrimidines (5a-i). Materials and Methods: Synthesis was carried out though the microwave assisted synthesis, Spectro…
Article
Synthesis, Characterization, in silico and in vivo Evaluation of Amino Acid Derived Schiff Bases of Quinoline- Benzimidazole Hybrids as Anti-epileptic Agents
Sonakshi Tyagi, Salahuddin Salahuddin, Avijit Mazumder, Rajnish Kumar, Vimal Datt, Km. Shabana, Abhishek Shankar Sharma, Mohamed Jawed Ahsan, Mohammad Shahar Yar
pp. s80–s92 · DOI: 10.5530/ijper.58.1s.8 · Published 2024
Aim/Background: Novel quinoline compounds containing benzimidazole have been synthesized in a number of different ways and screened for anti-epileptic potential through in vivo and in silico studies. Materials and Method…
Article
Quinazolin-4-one Derivatives: Enoyl-acyl Carrier Protein (ACP) Reductase (InhA) Antagonists Using in silico Drug Design Approach
Kavitha K, Mohan S, Jothikanth. V, Srinivasan N, Manojkumar S, Esakiprasanth. R, Bakitha Jessila M, Revathi P, Venkatesh V, Subash M
pp. s93–s102 · DOI: 10.5530/ijper.58.1s.9 · Published 2024
Aim: The configuration found programmed recreation ligand-receptor relations were worn during rework also rationale of investigate in order to establish budding bio-energetic candidate seeing that (Enoyl-ACP)-Enoyl-acyl …
Article
Development and Evaluation of Self Micro-Emulsifying Formulation of Venlafaxine HCl with Improved Antidepressant Activity
sanjeevanisd yahoo.com
pp. s103–s112 · DOI: 10.5530/ijper.58.1s.10 · Published 2024
Aim/Background: Venlafaxine HCl (VEN) is an antidepressant drug with extensive first pass metabolism and low oral bioavailability. In the present study, a solid self-emulsifying formulation of Venlafaxine was developed a…
Article
Floating Drug Delivery of Sustained Release Anti-depressant Mirtazapine Tablets by Box-Behnken Design: Formulation and Optimization
Challa Taraka Ramarao, Suvvari Bhagya Laxmi
pp. s113–s125 · DOI: 10.5530/ijper.58.1s.11 · Published 2024
Background: Mirtazapine widely prescribed Antidepressant drug that belongs to BCS Class II drug with low solubility and high permeability characteristics. Aim: The Box Behnken design was used to statistically optimize th…
Article
Design Expert-Implemented Nimodipine-Loaded Lyophilized Nanoemulsifying Drug Delivery System for Improved Oral Bioavailability and Physical Stability
Prativa Das, Jnyanaranjan Panda, Goutam Kumar Jena, Chinam Niranjan Patra, Kahnu Charan Panigrahi
pp. s126–s138 · DOI: 10.5530/ijper.58.1s.12 · Published 2024
Purpose:To improve the oral bioavailability as well as the physical stability of nimodipine, Design-Expert-driven nimodipine loaded nanoemulsifying drug delivery system was developed with a certain quality target product…
Article
Design and Evaluation of Different Transdermal Therapeutic Systems of Promethazine Hydrochloride
Suddala Shirisha, Sunit Kumar Sahoo, Tallam Veena, Yamsani Madhusudan Rao
pp. s139–s148 · DOI: 10.5530/ijper.58.1s.13 · Published 2024
Background: Promethazine Hydrochloride is a water-soluble drug and it suffers from poor bioavailability (25%) when given through oral route due to extensive first-pass metabolism. To overcome hepatic first pass metabolis…
Article
Fabrication, Characterization, and in vitro Evaluation of Atenolol Loaded Microsponges for Ocular Delivery
Archana Dhyani, Ganesh Kumar
pp. s149–s157 · DOI: 10.5530/ijper.58.1s.14 · Published 2024
Aim: The purpose of the study was development and evaluation of Atenolol loaded microsponge in situ gel for the management of ocular hypertension, glaucoma. Materials and Methods: The microsponges were prepared by modifi…
Article
Amelioration of Dissolution Properties of Abiraterone Acetate via Nano-Sizing Employing High-Speed Homogenization Technique: An Optimization Study
Patel Rajendra, Parmar Komal
pp. s158–s166 · DOI: 10.5530/ijper.58.1s.15 · Published 2024
Background: Abiraterone acetate is an anticancer molecule indicated for prostate cancer. The purpose of this study was to develop a nanosuspension of abiraterone acetate in order to improve its solubility, dissolution pr…
Article
Formulation and Evaluation of Floating Oral in situ Gel of Liquorice Extract
Kiran Kumar Yadiki, Umashree Kokatanur, Panchaxari Mallappa Dandagi, Sujay Hulyalkar
pp. s167–s175 · DOI: 10.5530/ijper.58.1s.16 · Published 2024
Background: Thein situ gel, which after gelation floats in the stomach, is appropriate for sustaining drug release. Aqueous extract of liquorice used for the treatment of peptic ulcers and Helicobacter pylori, was used t…
Article
Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption
Nagasen Dasari, Chirravuri Satyanarayana Phani Kumar, Rama Krishna Gummadi, Sai kiran Pindiprolu, Sujiya Balla, Amala Masa, Lavanya pulidindi, Vajrapu Subhaveera Prasanth
pp. s176–s186 · DOI: 10.5530/ijper.58.1s.17 · Published 2024
Objectives: The objective of this study was to develop a stable and effective form of an Orodispersible tablet containing Nicardipine Hydrochloride for the immediate treatment of high blood pressure and angina. The aim w…
Article
Self-Nanomicellar Dispersion of Rosuvastatin for Improved Bioavailability: Formulation, Optimization and Pharmacokinetic Studies
Sridevi Gowripattapu, SathisKumar Dinakaran, Selvamuthukumar Subramanian
pp. s196–s205 · DOI: 10.5530/ijper.58.1s.19 · Published 2024
Introduction: Rosuvastatin is a statin drug used to lower cholesterol, but it has poor water solubility and low bioavailability, limiting how effective it can be. The objective of the present study was to formulate and e…
Article
Evaluation of in vitro Anti-cancer Activity of Linum usitatissimum and Mentha spicata Combination Extract against MCF7 Breast Cancer Cell-line
Ashwini T, Glory Josephine I, Arul Amutha Elizabeth
pp. s212–s216 · DOI: 10.5530/ijper.58.1s.21 · Published 2024
Background/Aim:Breast cancer is one of the most common cancers among women in India. Though the current treatment is beneficial, it is complicated with lots of risks and disadvantages. So, the search for alternatives esp…
Article
High-Performance Liquid Chromatography Method Development and Validation for Estimation of Mahanimbine in Curry Leaves
Kanchan Nikam, Sachin Bhusari, Pravin Wakte
pp. s217–s223 · DOI: 10.5530/ijper.58.1s.22 · Published 2024
Aim: A designed, improved, and validated isocratic High Performance Liquid Chromatography method was used to study mahanimbine. Background: The method is evaluated for linearity, range, system applicability, LOD, LOQ, ac…
Article
Bio-analytical Method Development for Pharmacokinetic Study of Novel Lafutidine Formulation in Rabbit Plasma Using RP-HPLC
Shanti Sagar, Lankalapalli Srinivas
pp. s224–s231 · DOI: 10.5530/ijper.58.1s.23 · Published 2024
Objectives: The main objective of the study is to carry out comparative in vivo pharmacokinetic study of novel formulation with marketed formulation of lafutidine using HPLC method. Materials and Methods: The animals wer…
Article
Development and Validation of Stability-indicating HPLC Method for Estimation of Azilsartan in Pharmaceutical and Solid Lipid Nanoparticles
Neha Sanjay Bhasagi, Bhaskar Kallappa Kurangi, Vishal Arvind Mane, Swapnil Pandurang Patil, Moazzim Mainoddin Soudagar, Supriya Suresh Chimgave
pp. s232–s240 · DOI: 10.5530/ijper.58.1s.24 · Published 2024
Introduction: Azilsartan has been scientifically proven to be effective in treating hypertension. According to International Conference on Harmonization, the HPLC method was developed and validated to estimate the azilsa…
Article
Association and Prevalence of Alcoholism in Epileptic Patients at Tertiary Care Teaching Hospital
Saurav Raj, Megha Hegde, Anupama Harigal, Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy
pp. s241–s244 · DOI: 10.5530/ijper.58.1s.25 · Published 2024
Background: The effects of alcohol are complexly interlinked with the pathophysiology of epilepsy. Given that both epilepsy and alcohol have a significant detrimental impact on the brain; it is essential to investigate a…
Article
Evaluation of Prescriptions among Geriatric Patients Using Beer’s Criteria in a Tertiary Care Setting
Fathima Nashiya, Hina Aisha, Chithrakshi Sapalya, Melwin Varghese, Sajan Francis P, Archana Bhat
pp. s245–s251 · DOI: 10.5530/ijper.58.1s.26 · Published 2024
Introduction: The geriatric population is prone to physiologic changes, thus increasing the risk of medication-related problems. The use of potentially inappropriate medications is associated with profound medical and sa…
Article
Evaluation of the Anti-ulcer Activity of Curcumin and Linseed Oil in an NSAID-induced Gastric Ulcer Model in Rats
Alveera Zubair Ansari, Gaurav Mahesh Doshi
pp. s252–s261 · DOI: 10.5530/ijper.58.1s.27 · Published 2024
Background: Peptic Ulcer Disease is characterized by acid-induced ulcers in the stomach and duodenum. Their denuded mucosa with the distortion which extends into the submucosa or muscularis propria distinguishes them. Th…
Article
In vitro and in vivo Wound Healing Potential of Plant Commiphora caudata
Lavanya Athilli, Arumugam Balasubramaniam
pp. s262–s273 · DOI: 10.5530/ijper.58.1s.28 · Published 2024
Background:Commiphora caudata is commonly called hill mango, an incredibly available species of Commiphora, and belongs to Burseraceae. Commiphora caudata is commonly used in Ayurveda and Siddha medicines. Different part…
Article
Ethanolic Leaf Extract of Centella asiatica L. Possesses Nephroprotection in an Animal Model of Nephrotoxicity
Bhagya Venkanna Rao, Ramya Halasinamardhodi Beera Heggade, Hrishikeshavan Hiremagalur Jagannath
pp. s274–s281 · DOI: 10.5530/ijper.58.1s.29 · Published 2024
Background: Nephrotoxicity is a significant adverse effect of gentamicin, which is thought to be related to reactive oxygen species in the kidney. The purpose of this study was to look at how gentamicin-induced nephrotox…
Article
Investigation of Memory Enhancing Activity of Combination Extracts of Bauhinia variegata and Madhuca longifolia Leaves against Colchicine: An Experimental Study and Biochemical Alterations in Mice
Pragati Khare, Kamal Kishore, Dinesh Kumar Sharma, Noopur Khare
pp. s282–s288 · DOI: 10.5530/ijper.58.1s.30 · Published 2024
Objectives: To investigate the role of combination of Madhuca longifolia (ML) andBauhinia variegata (BV) ethanolic leaf extracts against oxidative damage in Swiss Albino mice and colchicine induced cognitive dysfunction;…
Article
Design Formulation and in vitro Evaluation of Gastroretentive Microspheres of Selegiline Hydrochloride for Parkinson’s Disease by Design Expert
Raghavarapu Prasanthi, Balusu Haarika, Subramanian Selvamuthukumar
pp. s289–s297 · DOI: 10.5530/ijper.58.1s.31 · Published 2024
Introduction: Selegiline hydrochloride is primarily used to treat Parkinson’s disease. Selegiline hydrochloride mucoadhesive microspheres were prepared to improve the bioavailability of the drug and its appropriate thera…
Article
Secondary Metabolites and Antioxidants Activity from Citronella Grass Extract (Cymbopogon nardus L.)
Rofiatun Solekha, Hery Purnobasuki, Ni Nyoman Tri Puspaningsih, Putri Ayu Ika Setiyowati
pp. s298–s305 · DOI: 10.5530/ijper.58.1s.32 · Published 2024
Background: Cymbopogon nardus L. is a rhizome plant that is widely used as traditional medicine. This research aimed to identify how the secondary metabolites of citronella grass including stems, leaves, and roots and ot…
Article
Enhancement of Solubility of Albendazole by Inclusion Complexation with Nanosponges and β-Cyclodextrin
Monica Raghavendra Prasad Rao, Saloni A. Sakharwade
pp. s306–s315 · DOI: 10.5530/ijper.58.1s.33 · Published 2024
Aim: Objective of work was to compare role of β-Cyclodextrin (β-CD) and Nanosponges (NS) prepared with different cross-linking ratios and different drug loading ratios to enhance solubility and dissolution rate of Albend…
Article
Preparation, in vitro and in vivo Characteristics of Floating in situ Gel of Carvedilol Using Semi Synthetic and Natural Polymers to Enhance the Oral Bioavailability
Ananthakumar Ramalingam, Sathesh Kumar Sukumaran, Chitra Krishnan
pp. s316–s324 · DOI: 10.5530/ijper.58.1s.34 · Published 2024
Background/Aim:The purpose of this study was to design and prepare floatingin situ gel to sustain Carvedilol (CVD) release and enhance oral bioavailability. Various floating in situ gel formulations of the CVD were prepa…
Article
Development and Validation of a Bioanalytical Method to Determine Empagliflozin in Human Plasma Using UPLC-MS/MS
Mani Sumithra, David John Andrew, Muthukumar Vijey Aanandhi
pp. s581–s325 · DOI: 10.5530/ijper.58.1s.35 · Published 2024
Aim: The study we are conducting aims to establish a validated method for measuring empagliflozin in plasma using UPLC MS/MS. Materials and Methods: Sodium-Glucose co Transporter inhibitors (SGLTi), a novel class of diab…
Article
Regulatory Gap Analysis and Challenges in the Development of a Novel Candidate Vaccine in India
Chandrashekar Ranga, Tanveer Naved, Arti Thakkar
pp. · DOI: 10.5530/ijper.58.1s.20 · Published 2024
Background: The vaccine is a means to control and eradicate infectious diseases and also to strengthen health systems. There should be a complete ecosystem in a well-defined, transparent, and predictable regulatory syste…
Article
Formulation, Development and Characterization of PLGA-Luliconazole Nanoparticles Loaded Gel System for Topical Fungal Treatment
Santosh S. Chhajed, Umesh D. Laddha, Sandeep S. Sonawane, Mrunal Pekhale, Prajakta Thorat, Sanjay J. Kshirsagar, Jaipraksh N. Sangshetti
pp. · DOI: 10.5530/ijper.58.1s.18 · Published 2024
Background: Fungal infections are the primary cause of skin diseases. Topical application of antifungal drugs is the most preferred treatment which is associated with key limitations viz. need for high doses and frequenc…