Volume 58, Issue 2S

Apr-Jun 2024 · pp. s484–s501 · 36 articles

Volume: 58
Issue: 2S
Published: Apr-Jun 2024
Pages: s484–s501
Articles: 36
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Original Article Review Article

In this issue

Original Article

Article
Clinical Efficacy and Safety of Ceftriaxone in Surgical Prophylaxis: A Systematic Review and Meta-Analysis
Shwetha Somakumar, S Elstin Anbu Raj, Gabriel Sunil Rodrigues, V Rajesh
pp. s332–s339 · DOI: 10.5530/ijper.58.2s.36 · Published Apr-Jun 2024
Introduction Adequate antimicrobial monitoring helps identify the changing pattern of infection prevention postoperatively. The review aims at assessing the efficacy and safety of prophylactic ceftriaxone in surgical sit…
Article
A Biochemical and Molecular Insight to Wound Healing Properties of Traditional Indian Medicines in Normal and Diabetic Rats
Sushma Prabhath, Kumar M R Bhat, K. Sreedhara R Pai, Manas Kinra, Karthik Gourishetti
pp. s359–s371 · DOI: 10.5530/ijper.58.2s.39 · Published Apr-Jun 2024
Background Honey, ghee, Glycyrrhiza glabra L. (GG), and Nerium indicum Mill. (NI) have been effectively used in Ayurveda and Indian folk medicine for healing both normal and diabetic wounds. However, the exact biochemica…
Article
Chlorogenic Acid, a Potential Glucose-6-Phosphatase Inhibitor: An Approach to Develop a Pre-Clinical Glycogen Storage Disease Type I Model
Santosh B Patil, Pramod C Gadad
pp. s372–s381 · DOI: 10.5530/ijper.58.2s.40 · Published Apr-Jun 2024
Introduction Gluconeogenesis and glycogenolysis are highly regulated metabolic processes that are critical in maintaining blood glucose levels within the physiological range. Any aberration in the regulation of these pro…
Article
Identification of Phorbol Ester and its Degradation by Traditional Purification Method in the Root of Baliospermum montanum (Willd.) Muell. Arg
Jayshree Vishnupant Changade, Ashwini Shete, Asha Thomas, Rabindra K Nanda
pp. s382–s388 · DOI: 10.5530/ijper.58.2s.41 · Published Apr-Jun 2024
Background Currently five types of phorbol esters are reported in the root of Balliospermum montanum Muell. Here we observed the presence of 12-myristate 13-acetate (C36H56O8) in the root, an additional phorbol ester whi…
Article
Formulation and Physicochemical Evaluation of Joshanda (Decoction) Munzije Balgham as Granules
Sabeena Shah, Hamiduddin, Nagraj
pp. s389–s402 · DOI: 10.5530/ijper.58.2s.42 · Published Apr-Jun 2024
Background Joshanda (decoction) is an effective dosage form in Unani System of Medicine but its unpalatable taste and preparation creates difficulty in patient compliance. Joshanda when freshly prepared has a very short …
Article
Evaluation of the Feasibility of Transdermal Delivery of Neratinib (NB) Loaded Microneedles to Treat Breast Cancer
Aravindram Attiguppe Seetharam, Meghana Goravinahalli Shivananjegowda, Krishnarajan Bangarurajan, Devegowda Vishakante Gowda
pp. s403–s411 · DOI: 10.5530/ijper.58.2s.43 · Published Apr-Jun 2024
Background Breast cancer is the world’s second-largest leading cause of death in women. Targeting highly localized tumors using transdermal microneedle drug delivery can be highly advantageous in treating breast cancer. …
Article
Box Behnken's Design of Fast-Dissolving Ondansetron Buccal Films and Assessing the Impact of Independent Variables on their Swelling and Folding Endurance Constraints
Dudekula Chand Basha, Bono Naga Sudha
pp. s412–s419 · DOI: 10.5530/ijper.58.2s.44 · Published Apr-Jun 2024
Objectives The project intends to create and evaluate oral fast-dissolving Ondansetron (ODN) films and explore how different plasticizers and polymers affect ondansetron release at varied doses. Materials and Methods The…
Article
Synthesis of Curcumin-Loaded Complex Coacervate of Chitosan Phosphate and Sodium Alginate and Study of their Antibacterial Activity
Arunima Sarma, Chayanika Deka, Sashi Prava Devi, Dilip Kumar Kakati
pp. s420–s428 · DOI: 10.5530/ijper.58.2s.45 · Published Apr-Jun 2024
Background In a system of two oppositely charged colloids a spontaneous liquid-liquid phase separation is termed as complex coacervation and the separated phase is called coacervate. In recent times coacervates prepared …
Article
An Exploration of Chrysin Fabricated Silver Nanoparticles as Antibiofilm Agent against Pseudomonas aeruginosa
Arnica F Lal, Pushpraj S Gupta
pp. s429–s435 · DOI: 10.5530/ijper.58.2s.46 · Published Apr-Jun 2024
Background Pseudomonas aeruginosa (P. aeruginosa) is the source of serious nosocomial infections, the most common of which is ventilator-associated pneumonia. P. aeruginosa infections continue to pose a substantial thera…
Article
Formulation and Evaluation of Valsartan Tablets Using Starch Succinate as Novel Super Disintegrant by Using 32 Factorial Design
Kollipara Naga Venkata Chenchu Lakshmi, Shaik Aminabee, Kunderu Ravi Shankar, Gangireddy Ramana, Shaik Almaas Sultana, Dasari Naga Rama Keerthana, Gundu Bhagya Sri, Challa Suma Niharika
pp. s436–s443 · DOI: 10.5530/ijper.58.2s.47 · Published Apr-Jun 2024
Aim The current study focuses on enhancing the dissolution pace of Valsartan, as BCS Class II. The objective is to develop fast-dissolving tablets of Valsartan by forming complexes with β-Cyclodextrin (β-CD). Materials a…
Article
Quality by Design (QbD) Aided Formulation Optimization of Amlodipine Besylate Oral Thin Film
Abhiram Kumar, Madhaw Kumar, Romi Singh, Pratibha Upadhyay, Anubhab Mukherjee
pp. s444–s452 · DOI: 10.5530/ijper.58.2s.48 · Published Apr-Jun 2024
Background Oral Thin Film (OTF) is an emerging approach for oral drug delivery but still there exists a scarcity of evidence for formulation optimization techniques. Herein, we aim to develop OTFs optimized by the QbD ap…
Article
Enhanced Bioavailability of Valsartan through Mucoadhesive Pellets Fabricated via Fluidized Bed Processor: A Novel Drug Delivery Approach
Nayana Baste, Hemant Gangurde, Charulata Nemade, Hitesh Shahare, Manisha Bihani
pp. s453–s467 · DOI: 10.5530/ijper.58.2s.49 · Published Apr-Jun 2024
Background Novel delivery strategies are being explored since low bioavailability presents a challenge for medications like valsartan. Mucoadhesive drug delivery systems present a viable alternative by enhancing drug abs…
Article
Development of Nanoparticle-Based Biodegradable Polymer Composite Film for Antifungal Drug Delivery in Prosthetic Joint Infection
Rupali Kale, Sanjeevani Shekhar Deshkar, Pooja Dattatray Deshmane, Balasaheb Whagmare
pp. s468–s483 · DOI: 10.5530/ijper.58.2s.50 · Published Apr-Jun 2024
Background Fluconazole is an antifungal agent of triazole class. Fluconazole is one of the most prescribed antifungal agents because of its excellent bioavailability, tolerability and side effect profile. To maintain dru…
Article
Quality by Design Assisted Development of Fast Dissolving Buccal Film of Ivabradine
Anushree Sunil Kumar, Kavitha Arenur Narayana Reddy, Rohith Narayana Reddy, Kavya Shivashankar Reddy, Raman Dang
pp. s484–s501 · DOI: 10.5530/ijper.58.2s.51 · Published Apr-Jun 2024
Background Buccal drug delivery is a novel drug delivery system ensure fast onset of action and avoids the first pass metabolism and ultimately improves the bioavailability. Aim The present investigation is oriented towa…
Article
Cubosome-based Corticosteroidal Drug Delivery System for Sustained Ocular Delivery: A Pharmacokinetic Investigation
Snehal Shashikant Chakorkar, Jameel Ahmed Sayed Gous Mulla
pp. s502–s514 · DOI: 10.5530/ijper.58.2s.52 · Published Apr-Jun 2024
Background Fluorometholone is an anti-inflammatory glucocorticoid. It has been used in various ocular inflammatory as well as infectious conditions. Opting for sustained release in ocular drug delivery is a favorable opt…
Article
Synthesis and Biological Evaluation of 5,6-Dimethylthieno[2,3-d]Pyrimidin-4(3H)-One Derivatives as Selective Cyclooxygenase 2 Inhibitors
Lim Tse Mun, Jamie Kow Kean Hing, Pran Kishore Deb, Katharigatta Narayanaswamy Venugopala, Raghu Prasad Mailavaram, Ammena Yahia Binsaleh, Sireen Abdul Rahim Shilbayeh
pp. s515–s520 · DOI: 10.5530/ijper.58.2s.53 · Published Apr-Jun 2024
Background NSAIDs are well-established for treating pain, fever, and inflammation mainly by inhibiting inducible Cyclooxygenase 2 (COX-2) isoenzyme. However, most of the marketed NSAIDs non-selectively inhibit physiologi…
Article
In vitro Antibacterial Evaluation and in silico Docking of Schiff Base as a Potential Inhibitor of Nucleoside Diphosphate Kinases
Archana Tomer, Vishnu Vats, Smriti Bansal, Pravita Kumar, Yogendra Kumar, Anjana Sarkar
pp. s521–s531 · DOI: 10.5530/ijper.58.2s.54 · Published Apr-Jun 2024
Aim Schiff bases are vital Compounds of organic chemistry; they have exhibited more potential biological activities namely antiviral, antibacterial, and antifungal characteristics. Molecular docking studies suggested tha…
Article
A Validated Simple, Rapid and Accurate RP-HPLC Approach for Measuring Vardenafil Hydrochloride Trihydrate in Bulk Drugs and Medicinal Formulations
Ganesh Ramesh Gadekar, Rajendra Chandrashekhar Doijad, Namdeo Ramhari Jadhav, Somnath Devidas Bhinge
pp. s532–s542 · DOI: 10.5530/ijper.58.2s.55 · Published Apr-Jun 2024
Background Shortcomings in current analytical methods characterized by time-consuming procedures, limited sensitivity, and high costs associated with reagents and instruments, influence the research background. Objective…
Article
Assessment and Comparison of Greenness of UV-Spectroscopy Methods for Simultaneous Determination of Anti-Hypertensive Combination
Suvarna Yenduri, H N Varalakshmi, Naga Prashant Koppuravuri
pp. s543–s551 · DOI: 10.5530/ijper.58.2s.56 · Published Apr-Jun 2024
Background Environmentally destructive analytical research practices, such as using and releasing hazardous solvents and reagents into the atmosphere, have brought up serious concerns regarding the ecological impact of t…
Article
Simultaneous Determination of Amitriptyline Hydrochloride and Propranolol Hydrochloride in Commercial Formulation by Multitudinal UV and Multivariate FT-IR Spectroscopic Methods
Sreenivasa Charan Archakam, Keerthisikha Palur, Rajitha Galla, Sai Sucharitha Padiri, Praveen Kumar Tulasi, Ranganayakulu Diviti
pp. s552–s557 · DOI: 10.5530/ijper.58.2s.57 · Published Apr-Jun 2024
Aim In the current study, a multivariate FTIR method and two different UV spectrophotometric methods were employed for the simultaneous determination of Amitriptyline Hydrochloride (ATH) and Propranolol Hydrochloride (PP…
Article
Stability Indicating RP-UPLC Method for Impurity Profiling of Darunavir and Ritonavir in Fixed Dose Drug Combination Product
Munish Buch, Hasit Vaghani
pp. s558–s565 · DOI: 10.5530/ijper.58.2s.58 · Published Apr-Jun 2024
Background The goal of the proposed study was to develop and validate stability indicating mass compatible reverse phase UPLC method for impurity profiling of Darunavir Ethanolate and Ritonavir degradation impurities in …
Article
Rapid, Cost Effective and Simple Analytical Method Development and Validation for Simultaneous Estimation of Thymol and Cholecalciferol by Ultraviolet Spectrophotometry
Prasad Buchkul, Shyam Khante, Nilesh Desai-Deshmukh
pp. s566–s574 · DOI: 10.5530/ijper.58.2s.59 · Published Apr-Jun 2024
Background Thymol and Cholecalciferol in a combined approach can be used as antioxidant, free radical scavenging, anti-depressant, anti-inflammatory, anti-diabetic, anti-arthritis etc. So, rapid, cost effective and simpl…
Article
The Fast and Simple LC-MS/MS Method for Determination of Rifampicin in the Human Blood Plasma
V Baskaran, P. D. Chaithanya Sudha, T Abishek, R Hariesh Kumar, G Ramesh, Raman Dang
pp. s575–s581 · DOI: 10.5530/ijper.58.2s.60 · Published Apr-Jun 2024
Background Rifampicin is an important anti tuberculosis drug for the early infection and, more importantly, bactericidal activity against mycobacterium tuberculosis. LC-MS/MS, with the required molecular specificity, pro…
Article
Stability Indicating Assay for the Determination of Bilastine in Bulk Drug and Method Development Validation by RP-HPLC Using Analytical Quality by Design Approaches
Anjali Nayak, R Maria Danish Alwin, G Sangeetha, C Y Sowmya, Yashwanth V Reddy, Raman Dang
pp. s582–s590 · DOI: 10.5530/ijper.58.2s.61 · Published Apr-Jun 2024
Background Regulatory organizations have acknowledged the need for systematic rules for understanding development as a result of the large increase in concerns and criticism regarding the quality and pharmaceutical produ…
Article
Development and Validation of High-Performance Thin Layer Chromatographic Method for Estimation of Acyclovir
Pai Raksha, Somasekhar Vanita, Purushottaman Vijayanthimala, Chandran Athira
pp. s591–s597 · DOI: 10.5530/ijper.58.2s.62 · Published Apr-Jun 2024
Background The antiviral medication genre comprises the synthetic purine nucleoside analogue acyclovir, which particularly is used to treat varicella-zoster and herpes simplex virus infections. By incorporating into vira…
Article
RP-HPLC Method Development and Validation of Choline Salicylate and Lignocaine HCl in Mouth Ulcer Gel
Sivanathan Boopalan, Palla Venkata Murali Krishna, Vanita Somasekhar, Venketesh Dubalgundi, Shruthi Devadiga
pp. s598–s605 · DOI: 10.5530/ijper.58.2s.63 · Published Apr-Jun 2024
Objectives The prime intent of the current study is to develop a rapid, reliable, robust and cost-effective reversed-phase HPLC method for simultaneous estimation of Choline Salicylate and Lignocaine HCl in mouth Ulcer G…
Article
Rapid, Simple and Low-Cost Reverse-Phase High-Performance Liquid Chromatography Tool for Estimation of Methotrexate: Testing Application in Standard Laboratory Bulk, Marketed Dosage Form, and Release kinetics in Nanoformulation
Muktika Tekade, Mukesh Chandra Sharma
pp. s606–s615 · DOI: 10.5530/ijper.58.2s.64 · Published Apr-Jun 2024
Background Methotrexate (MTX) is one of the utmost commonly prescribed drugs, which is official in the IP, BP, and USP. MTX is a potent drug that can cause serious side effects if not used in the correct quantity. Assayi…
Article
Apoptotic Activity of Protopine against Human Breast Cancer Cell Lines: An in vitro Study
Shoujun Li, Gothai Sivapragasam, Palanisamy Arulselvan, Aimi Syamima Abdul Manap
pp. s616–s622 · DOI: 10.5530/ijper.58.2s.65 · Published Apr-Jun 2024
Background Breast Cancer continues to rank among all cancer types as the most dangerous malignancies, accounting for a significant portion of cancer-associated mortalities among women globally. Additionally, the number o…
Article
Bridging Tradition and Innovation: The Hail Desert Plant Database for Drug Discovery
Mohd Saeed, Sabiha Naaz, Munazzah Tasleem, Nawaf Alshammari, Arminder Kaur, Mohammad Jahoor Alam, Amir Saeed
pp. s623–s630 · DOI: 10.5530/ijper.58.2s.66 · Published Apr-Jun 2024
Introduction The Hail Desert Plant Database serves as an extensive repository that has been created to consolidate and systematize information concerning medicinal plants that are native to the arid Hail region in Saudi …
Article
Development and Validation of a Stability Indicating HPTLC Method for Simultaneous Estimation of Telmisartan and Gallic Acid as per ICH Q1A (R2)
Swadesh Kumar Pattanik, Kishanta Kumar Pradhan
pp. s631–s639 · DOI: 10.5530/ijper.58.2s.67 · Published Apr-Jun 2024
Background A simple, selective and sensitive HPTLC method was developed for simultaneous estimation of Telmisartan (TEL) and Gallic acid (GA). Oxidative stress produces hypertension, GA having antioxidative property that…
Article
Biogenic Synthesis of Copper Oxide Nanoparticle from Aegle marmelos and its Anti-Cancerous Potential against HCT-116 Cell Line
Nizar A. Khamjan, Abdullah Farasani
pp. s640–s647 · DOI: 10.5530/ijper.58.2s.68 · Published Apr-Jun 2024
Background and Aim Colorectal cancer stands as a frequently occurring fatal disease for several decades and the use of nanoparticles has long been explored in cancer treatments. Engineering the size and shape to attain a…
Article
A Comparative Phytochemical Characterization of Moringa oleifera Plant Parts by Different Solvent Extraction
Gothai Sivapragasam, T Gokila Devi, Nanthiney Devi Ragavan, Nagaraja Suryadevara, Nanthini Sridewi, Sami Al Obaid, Sulaiman Ali Alharbi, Palanisamy Arulselvan
pp. s648–s659 · DOI: 10.5530/ijper.58.2s.69 · Published Apr-Jun 2024
Background M. oleifera is an enriched plant with a variety of rich ingredients that play a very important part in the human diet. Thus, scientists have great interest in assessing the medicinal value of the plant to prom…
Article
Systemic Effect of Human Follicular Fluid from Endometriotic and Healthy Subjects on Female Mice
Nidhi Gairola, Havagiray R Chitme, Reema Sircar
pp. s660–s667 · DOI: 10.5530/ijper.58.2s.70 · Published Apr-Jun 2024
Aim/Background Throughout oogenesis and folliculogenesis, the follicular fluid’s composition alters physiologically to fit the needs of particular microenvironmental demands. This study’s main goal was to compare the eff…
Article
Scientific Validation of Traditional Detoxification Process and Evaluation of its Impact on Anti-Microbial Potency, Phytochemical and Heavy Metals in Nigella sativa
Kalkatanur Ganesan Vanitha, Anbu Madheshwar Rajha Viknesh, Tahani Awad Alahmadi, Saleh H. Salmen, Natesan Sudhakar
pp. s668–s682 · DOI: 10.5530/ijper.58.2s.71 · Published Apr-Jun 2024
Background Medicinal plants are the best source for a variety of drugs. In traditional practices, the detoxification method is practiced to reduce toxicity of herbs, because low toxicity is one of the characteristics of …

Review Article

Review
Effectiveness of Complementary and Alternative Medicine and Physical Therapies in Peripheral Arterial Disease with Intermittent Claudication: A Systematic Review
Mohammed Kanan Alshammari, Khansa Hamza Hussain, Maali Ramadan Alshammari, Hanan Haif Alshammari, Hadeel Saad Althagafi, Hanan Rashad Bajunaid, Bashayr Abdullah Alanzi, Abdullah Ayed Alshammari, Abdulaziz Khalaf Alshammari, Mujtaba Abbas Jasim Aljasim, Yazeed Saud Alanizi, Wala’a Mohammed Al-Sulais, Ahad Aref Alsulays Nashi Dukhi Albaqami
pp. s340–s353 · DOI: 10.5530/ijper.58.2s.37 · Published Apr-Jun 2024
Aim/Background Peripheral Arterial Disease (PAD) affects the lower limbs. Globally there is a growing disease burden among the patients suffering from cardio-vascular disease and metabolic disorders. The purpose of this …
Review
Implementation of National Education Policy 2020 in Pharmacy Education
Rakesh Somani
pp. s354–s358 · DOI: 10.5530/ijper.58.2s.38 · Published Apr-Jun 2024
Precise and explicit education policy is requisite for a country at all education levels because education ushers to evolution of balance between economy and growth. India with the direction of current Prime Minister and…