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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

In vitro Antibacterial Evaluation and in silico Docking of Schiff Base as a Potential Inhibitor of Nucleoside Diphosphate Kinases

Archana Tomer1, Vishnu Vats2, Smriti Bansal1, Pravita Kumar3, Yogendra Kumar3★, Anjana Sarkar1★★ Corresponding author

  1. 1Department of Chemistry, Netaji Subhas University of Technology (N.S.U.T), Erstwhile N.S.I.T, Azad Hind Fauj Marg, Dwarka, Delhi, INDIA.
  2. 2Department of Applied Science and Humanities, G.B Pant DSEU Okhla-1 Campus, Delhi, INDIA.
  3. 3Department of Chemistry, Sri Aurobindo College Delhi (Delhi University), Delhi, INDIA.

CORRESPONDENCE

Yogendra Kumar

Anjana Sarkar Department of Chemistry, Netaji Subhas University of Technology (N.S.U.T), Erstwhile N.S.I.T, Azad Hind Fauj Marg, Dwarka, Delhi-110017, INDIA.

anjisarkar@gmail.com

Received: 26-06-2023; Revised: 19-11-2023; Accepted: 05-02-2024.

Volume 58, Issue 2S · pp. s521–s531 · PUBLISHED Apr-Jun 2024 · DOI: 10.5530/ijper.58.2s.54

View on IJPER original site ↗

ABSTRACT

Aim Schiff bases are vital Compounds of organic chemistry; they have exhibited more potential biological activities namely antiviral, antibacterial, and antifungal characteristics. Molecular docking studies suggested that strong binding energies, as well as favorable hydrogen bonds and hydrophobic interactions, could be beneficial for the pharmacological application of the compounds. Moreover, the aid of the ADMET score may support the therapeutic action of potential pharmaceutical compounds. Materials and Methods In the present work, In vitro studies were conducted on five Schiff bases named BIP, CIP, PT, NIP, and DPIP against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa. In silico studies were also performed on the same five Schiff bases, evaluating their interaction with the target proteins of Staphylococcus aureus and Escherichia coli. Results In vitro results of BIP and NIP showed mild MIC (minimum inhibition concentration) against Staphylococcus aureus and Escherichia Coli respectively, while PT showed good MIC against pathogenic bacteria Staphylococcus aureus which was upheld by in silico study. Conclusion We hope the findings of the present study should contribute to developing a good anti-bacterial drug.

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    Tomer, A., Vats, V., Bansal, S., Kumar, P., Kumar, Y., & Sarkar, A. (2024). In vitro Antibacterial Evaluation and in silico Docking of Schiff Base as a Potential Inhibitor of Nucleoside Diphosphate Kinases. Indian Journal of Pharmaceutical Education and Research, 58(2S), s521–s531. https://doi.org/10.5530/ijper.58.2s.54