jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Box Behnken's Design of Fast-Dissolving Ondansetron Buccal Films and Assessing the Impact of Independent Variables on their Swelling and Folding Endurance Constraints

Dudekula Chand Basha1, Bono Naga Sudha2

  1. 1Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Anantapur, Ananthapuramu, Andhra Pradesh, INDIA.
  2. 2Department of Pharmaceutics, Creative Educational Society’s College of Pharmacy-(CESCOP) Affiliated to Jawaharlal Nehru Technological University, Anantapur, Ananthapuramu, Kallur, Kurnool, Andhra Pradesh, INDIA.

CORRESPONDENCE

Dudekula Chand Basha Research Scholar, Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Anantapur, Ananthapuramu-515001, Andhra Pradesh, INDIA.

dchandknl@gmail.com

Received: 01-05-2023; Revised: 23-11-2023; Accepted: 11-02-2024.

Volume 58, Issue 2S · pp. s412–s419 · PUBLISHED Apr-Jun 2024 · DOI: 10.5530/ijper.58.2s.44

View on IJPER original site ↗

ABSTRACT

Objectives The project intends to create and evaluate oral fast-dissolving Ondansetron (ODN) films and explore how different plasticizers and polymers affect ondansetron release at varied doses. Materials and Methods The solvent casting method was used to make the films. Complex formation and compatibility were evaluated using spectral and calorimetric methods to confirm. Utilising the core composite design, which included 13 different Ondansetron Fast-Dissolving Oral Films (OFDOFs) formulas, the produced Ondansetron Fast-Dissolving Oral Films (OFDOFs) were optimised. Using the Design Expert-v.11 software, the impacts of three variables, including HPMC K4M (X1), Carbopol 934 P (X2), and propylene glycol levels (X3), on two responses, Folding Endurance (FE) and Swelling Index (SI), were examined. Numerical optimisation increased the FE (Y1) and maximised the SI (Y2). Results The statistical analysis findings showed that X1 greatly enhances Y1 and Y2. While X2 and X3 significantly prejudiced the responses optimistically. It was found that the best films were created at the midpoint concentration of both X1 and X2. Moreover, as X3 levels increased, the elasticity and FE also improved, in addition to the film’s quality. Conclusion The study concludes that the prepared buccal films of ODN exhibited great mechanical and physical qualities in addition to their other physicochemical assets. This dosage form is expected to offer a bioavailability benefit over conventional dosage forms due to its rapid onset of action and anticipated partial avoidance of pre-systemic metabolism.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Basha, D. C., & Sudha, B. N. (2024). Box Behnken's Design of Fast-Dissolving Ondansetron Buccal Films and Assessing the Impact of Independent Variables on their Swelling and Folding Endurance Constraints. Indian Journal of Pharmaceutical Education and Research, 58(2S), s412–s419. https://doi.org/10.5530/ijper.58.2s.44