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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Review

Effectiveness of Complementary and Alternative Medicine and Physical Therapies in Peripheral Arterial Disease with Intermittent Claudication: A Systematic Review

Mohammed Kanan Alshammari1★, Khansa Hamza Hussain2, Maali Ramadan Alshammari3, Hanan Haif Alshammari3, Hadeel Saad Althagafi4, Hanan Rashad Bajunaid5, Bashayr Abdullah Alanzi3, Abdullah Ayed Alshammari6, Abdulaziz Khalaf Alshammari7, Mujtaba Abbas Jasim Aljasim8, Yazeed Saud Alanizi9, Wala’a Mohammed Al-Sulais10, Ahad Aref Alsulays Nashi Dukhi Albaqami10★ Corresponding author

  1. 1Department of Clinical Pharmacy, King Fahad Medical City, Riyadh, SAUDI ARABIA.
  2. 2Department of Cardiac Science, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.
  3. 3Department of Pharmacy, Maternity and Children Hospital Rafah, Rafha, SAUDI ARABIA.
  4. 4Department of Clinical Pharmacy, Western Zone, Taif, SAUDI ARABIA.
  5. 5Department of Community Pharmacy, Kol Alosra, Western Zone, Taif, SAUDI ARABIA.
  6. 6Department of Pharmacy, Prince Sultan Cardiac Center, Riyadh, SAUDI ARABIA.
  7. 7College of Pharmacy, Northern Border University, Hafar Al-Batin, SAUDI ARABIA.
  8. 8College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, SAUDI ARABIA.
  9. 9College of Pharmacy, Northern Border University, Rafha, SAUDI ARABIA
  10. 10College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.

CORRESPONDENCE

Mohammed Kanan Alshammari

Department of Clinical Pharmacy, King Fahad Medical City, Riyadh-12211, SAUDI ARABIA.

ii_kanan101@outlook.com

Received: 03-07-2023; Revised: 06-11-2023; Accepted: 19-01-2024.

Volume 58, Issue 2S · pp. s340–s353 · PUBLISHED Apr-Jun 2024 · DOI: 10.5530/ijper.58.2s.37

View on IJPER original site ↗

ABSTRACT

Aim/Background Peripheral Arterial Disease (PAD) affects the lower limbs. Globally there is a growing disease burden among the patients suffering from cardio-vascular disease and metabolic disorders. The purpose of this review is to generate evidence on the efficacy of CAM therapies in PAD. Materials and Methods This systematic review was performed across the five electronic databases i.e. PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Ovid SP, ISI Web of Science, Elsevier Science Direct, and Wiley Online Library as per the PRISMA guidelines from inception till April 2022. Results After screening n=55,410 articles, n=77 articles were found to fulfill the eligibility criteria and were selected for this review. The nature of interventions investigated in the clinical trials were physical interventions including exercises of different forms, oral supplements, and other interventions such as chelation therapy, Tai Chi Chuan (TCC), Intermittent Mechanical Compression (IMC) device, connective tissue reflex massage, Remote Ischemic Preconditioning (RIC), Transcutaneous Electrical Nerve Stimulation (TENS) and heat therapy. Upon final assessment, it was revealed that physical activity had a positive effect on peripheral arterial disease patients’ quality of life. In addition,Ginkgo biloba and nitrate supplements were found effective for Intermittent Claudication (IC) and PAD patients. Conclusion This review suggests a positive impact of physical activity on peripheral arterial disease patients’ quality of life. Evidence also shows that Physical activity/ exercise-based intervention alone or in combination with the supplement is found to be effective among PAD patients and has shown significant results in intermittent claudication.

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    Alshammari, M. K., Hussain, K. H., Alshammari, M. R., Alshammari, H. H., Althagafi, H. S., Bajunaid, H. R., Alanzi, B. A., Alshammari, A. A., Alshammari, A. K., Aljasim, M. A. J., Alanizi, Y. S., Al-Sulais, W. M., & Albaqami, A. A. A. N. D. (2024). Effectiveness of Complementary and Alternative Medicine and Physical Therapies in Peripheral Arterial Disease with Intermittent Claudication: A Systematic Review. Indian Journal of Pharmaceutical Education and Research, 58(2S), s340–s353. https://doi.org/10.5530/ijper.58.2s.37