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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Evaluation of Anti-Depressant Activity of spirulina, a blue-green algae on Chronic Unpredictable Stress Induced Depression in Rats

Girish Meravanige Basavarajappa1, Juturu Balaraju2, Nimbagal Raghavendra Naveen3, Prakash Goudanavar3, Vakkalagadda Siva Ganesh3★, Sreeharsha Nagaraja4,5★, Predeepkumar Narayanappa Shiroorkar1, Mallikarjun Telsang6★ Corresponding author

  1. 1Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  2. 2Department of Clinical Pharmacology, Clinsync Clinical Research Pvt. Ltd., Telangana, INDIA.
  3. 3Department of Pharmaceutics and Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagar, Karnataka, INDIA.
  4. 4Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  5. 5Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.
  6. 6Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.

CORRESPONDENCE

Vakkalagadda Siva Ganesh

Department of Pharmaceutics and Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagar, Karnataka, INDIA.

Received: 22-03-2023; Revised: 15-06-2023; Accepted: 23-08-2023.

Volume 57, Issue 4 · pp. 1150–1158 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.4.113

View on IJPER original site ↗

ABSTRACT

Background: Depression is a crippling and pervasive illness that can affect a person in many different ways. It can be identified by certain symptoms, such as modifications in behaviour, psychological functioning, and brain physiology. Materials and Methods: One of the animal models for depression has been the Chronic Unpredictable Mild Stress (CUMS) paradigm. In this study, spirulina algae, which contains tryptophan, was chosen and tested for its anti-depressant effectiveness in the CUS model using Fluoxetine as the gold standard. Wistar rats were chosen to undergo the CUS process for 28 days, and throughout that time, the test drug was given at doses of 400 mg/kg. Results: Behavioural and biochemical parameters were analysed, and has shown significant changes. Conclusion: When compared to the CUS group, spirulina algae at the tested doses had a substantial impact on behavioural and metabolic testing. These findings demonstrated that Spirulina algae specifically exhibited an in vivo anti-depressant-like effect.

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    Basavarajappa, G. M., Balaraju, J., Naveen, N. R., Goudanavar, P., Ganesh, V. S., Nagaraja, S., Shiroorkar, P. N., & Telsang, M. (2023). Evaluation of Anti-Depressant Activity of spirulina, a blue-green algae on Chronic Unpredictable Stress Induced Depression in Rats. Indian Journal of Pharmaceutical Education and Research, 57(4), 1150–1158. https://doi.org/10.5530/ijper.57.4.113