Effect of a Herbal Formulation on Infection Prevention and Immune Regulation in Children with Frequent Relapse Nephrotic Syndrome
Haiyun Wang1, Binbin Tang1★, Junjie Shi2, Yan Wang3, Qili Wang3★ Corresponding author
- 1Second Outpatient Department, Tongde Hospital of Zhejiang Province, Hangzhou, CHINA.
- 2Clinical Medical College, Hangzhou Medical College, Hangzhou, CHINA.
- 3Department of Pediatrics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, CHINA.
CORRESPONDENCE
Binbin Tang
Second Outpatient Department, Tongde Hospital of Zhejiang Province, Hangzhou-310012, CHINA.
Received: 28-10-2022; Revised: 22-03-2023; Accepted: 23-06-2023.
Volume 57, Issue 4 · pp. 1251–1257 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.4.149
ABSTRACT
Objectives: This study aims to investigate the effect of a herbal formulation "Guyuan Tang" on preventing the recurrence of children with frequent relapse nephrotic syndrome and its influence on immune function. Materials and Methods: In all, 30 children with frequent relapse nephrotic syndrome were randomly divided into the Traditional Chinese Medicine (TCM) group and the control group. The control group was treated with conventional western medicine, while the TCM group was treated with Guyuan Tang for three months based a control group. The changes in the immune function indices before and after treatment were compared between the two groups, and the frequencies of infection and recurrence were compared after 12 months of follow-up. Results: The level of IgG protein, the proportion of CD3+CD4+T cells, CD4/CD8 and Treg cells in the TCM group increased after three months of Guyuan Tang treatment (p < 0.05), which showed statistical differences compared with the control group (p < 0.05). After one year of follow-up, no statistically significant difference was observed in the incidences of recurrence and infection between the two groups (p > 0.05), but the hospitalization rate and the average number of infections in the TCM group were significantly lower than those in the control group (p < 0.05). Conclusion: Guyuan Tang could reduce the frequency of infection in children with frequent relapse nephrotic syndrome, and regulating the proportion of Treg cells, CD4/CD8 and IgG may be one of its mechanisms.
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Wang, H., Tang, B., Shi, J., Wang, Y., & Wang, Q. (2023). Effect of a Herbal Formulation on Infection Prevention and Immune Regulation in Children with Frequent Relapse Nephrotic Syndrome. Indian Journal of Pharmaceutical Education and Research, 57(4), 1251–1257. https://doi.org/10.5530/ijper.57.4.149