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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Preparation and Optimization of Microwave-Assisted Ball-Milled Olmesartan Medoxomil with Chitosan Using Full 3^2 Factorial Design

Atul Shivaji Gurav1,2★, Ajit Shankarrao Kulkarni3★ Corresponding author

  1. 1Department of Pharmaceutics, Gourishankar Education Society’s Satara College of Pharmacy, Satara, Maharashtra, INDIA.
  2. 2Department of Pharmaceutics, Late Adv. Dadasaheb Chavan Memorial Institute of Pharmacy, Malwadi, Masur, Karad, Satara, Maharashtra, INDIA.
  3. 3Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, INDIA.

CORRESPONDENCE

Atul Shivaji Gurav

Assistant Professor, Department of Pharmaceutics, Late Adv. Dadasaheb Chavan Memorial Institute of Pharmacy, Malwadi, Masur, Karad, Satara, Maharashtra, INDIA.

atulgurav800@gmail.com

Received: 22-11-2022; Revised: 23-01-2023; Accepted: 30-03-2023.

Volume 57, Issue 3S · pp. s555–s563 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.3s.64

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ABSTRACT

Introduction: The anti-hypertensive drug Olmesartan Medoxomil (OLM), a BCS II drug, works by inhibiting the action of angiotensin II on AT1 receptors. Objectives: The purpose of the study was to enhance solubility and stability by altering crystalline form, which reduces cost and dose burden of the pharmaceutical industry. In the current study, OLM formulation was prepared by using a full 3 level 2 factorial design with chitosan and neusiline as independent factors. Materials and Methods: Chitosan, a hydrophilic and stabilizing polymer, was used to enhance solubility and stability with the help of neusiline as a surfactant. Formulation was prepare using microwave-assisted ball milled technology. Results and Discussion: In comparison to the pure drug, phase solubility study shows the ternary mixture's saturation solubility was around 12 times higher. Physical interaction between polymer and OLM was confirmed from the FTIR study, DSC graph, SEM surface morphological study and NMR study. The drug's altered crystalline form has been confirmed by XRD, which could alter its solubility and rate of dissolution. The optimized batch obtained from factorial design was used for electrically operated ball milling. This demonstrated a notable improvement in the solubility, stability, and dissolving rate. Conclusion: As a result, using chitosan with a microwave assisted ball milling process can be a novel breakthrough in enhancing the bioavailability of any BSC II medicines.

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    Gurav, A. S., & Kulkarni, A. S. (2023). Preparation and Optimization of Microwave-Assisted Ball-Milled Olmesartan Medoxomil with Chitosan Using Full 3^2 Factorial Design. Indian Journal of Pharmaceutical Education and Research, 57(3S), s555–s563. https://doi.org/10.5530/ijper.57.3s.64