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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Formulation and Evaluation of Antifungal Drug Containing Mucoadhesive Tablet for Vaginal Candidiasis

Pranita Sunil Kanojiya, Rita Naresh Wadetwar★, Amita Prasanna Godbole★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati Road, Nagpur, Maharashtra, INDIA.

CORRESPONDENCE

Rita Naresh Wadetwar

Dr. Mrs. Rita N. Wadetwar, Professor, Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati Road, Nagpur-440 033, Maharashtra, INDIA.

rnwadetwar1@gmail.com

Received: 27-10-2022; Revised: 28-03-2023; Accepted: 31-05-2023.

Volume 57, Issue 3S · pp. s573–s586 · PUBLISHED 2023 · DOI: 10.5530/ijper.57.3s.66

View on IJPER original site ↗

ABSTRACT

Objectives: Female population frequently seeks medical consultation for the vaginal candidiasis. Voriconazole (VOR) is a BCS class II antifungal drug with low aqueous solubility and hence inclusion complex was formulated using Hydroxypropyl-β-cyclodextrin (HPβCD). The complex was incorporated into mucoadhesive vaginal tablet using Chitosan and Hydroxypropyl Methyl Cellulose (HPMC K100). Materials and Methods: A 3^2 full factorial design was employed for sustained release tablet using Design expert® software. Results: Scanning Electron Microscopy (SEM) results indicated the complex formation between the drug and HPβCD. The batches showed 39.68±1.2 to 72.31±1.4% of drug release for 4 hr while for 8 hr it was from 77.23±1.5 to 99.82±1.1%. Therefore, the sustained release of drug was achieved for 8 hr. The tablet batches had swelling % from 228.51±12 to 323.11±8% and mucoadhesive strength from 1131.02±49 to 2302.12±55 dyne/cm^2. In the in vitro antifungal activity study, a higher zone of inhibition was observed for the inclusion complex-based tablet (34±0.3 mm) as compared to plain drug tablet (25±0.4 mm). Conclusion: Therefore, the inclusion complex-based vaginal tablet could be formulated successfully by employing 3^2 full factorial design for increased residence of drug at the vaginal site of infection and for improved therapeutic efficacy.

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    Kanojiya, P. S., Wadetwar, R. N., & Godbole, A. P. (2023). Formulation and Evaluation of Antifungal Drug Containing Mucoadhesive Tablet for Vaginal Candidiasis. Indian Journal of Pharmaceutical Education and Research, 57(3S), s573–s586. https://doi.org/10.5530/ijper.57.3s.66