jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Review

Natural and Synthetic Inhibitors of Heat Shock Protein 90 Chaperone in Cancer Treatment

Shravanthi Ravula1, Sravani Akula1, Rama Krishna Kancha1★★ Corresponding author

  1. 1Department of CPMB, Molecular Medicine and Therapeutics Laboratory, CPMB, Osmania University, Hyderabad, Telangana, INDIA.

CORRESPONDENCE

Rama Krishna Kancha

Department of CPMB, Molecular Medicine and Therapeutics Laboratory, CPMB, Osmania University, Hyderabad, Telangana, INDIA.

ramakancha@osmania.ac.in

Received: 24-12-2023; Revised: 04-10-2023; Accepted: 16-01-2023.

Volume 58, Issue 2 · pp. 401–410 · PUBLISHED 2024 · DOI: 10.5530/ijper.58.2.45

View on IJPER original site ↗

ABSTRACT

The heat shock protein 90 (HSP90) plays a crucial role in regulating cellular homeostasis. Importantly, enhanced dependence of cancer-specific proteins or mutants on HSP90 for their stability and activity offers HSP90 as an attractive therapeutic target. But, HSP90 being an important house-keeping protein, raised skepticism towards achieving cancer-specific therapeutic efficacy. Biochemical and functional studies revealed differential activity of HSP90 between healthy and cancer cells indicating the promise of specific chemical inhibitors in treating the disease. The current educational article elaborates on multiple classes of inhibitors that either have pre-clinical activity or being tested in various phases of clinical trials. In addition, recent pre-clinical findings that offer mechanistic insights into the therapeutic efficacy of HSP90 inhibitors are detailed. Thus, the article focuses on the promise of HSP90 as a therapeutic target and recent advances in the development of novel HSP90 inhibitors. Furthermore, we discuss the genetic factors and molecular mechanisms that influence the success of targeting HSP90 chaperone in cancer treatment.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Ravula, S., Akula, S., & Kancha, R. K. (2024). Natural and Synthetic Inhibitors of Heat Shock Protein 90 Chaperone in Cancer Treatment. Indian Journal of Pharmaceutical Education and Research, 58(2), 401–410. https://doi.org/10.5530/ijper.58.2.45