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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Assessment of Dolichandrone falcata Seem. Leaves for Anti-cancer Potential in Experimental Animal Models

Sachin N. Kapse1, Vaibhav G. Bhamare2★, Rakesh D. Amrutkar3, Rahul N. Patil4, Vinod R. Patil5, Gokul S. Talele1★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, Matoshri College of Pharmacy, Eklahare, Nashik, Maharashtra, INDIA.
  2. 2Department of Pharmaceutics, K. K. Wagh College of Pharmacy, Nashik, Maharashtra, INDIA.
  3. 3Department of Pharmaceutical Chemistry, K. K. Wagh College of Pharmacy, Nashik, Maharashtra, INDIA.
  4. 4Department of Pharmacology, Matoshri College of Pharmacy, Eklahare, Nashik, Maharashtra, INDIA.
  5. 5Department of Pharmacology, MGV’s SPH College of Pharmacy, Malegaon Camp, Malegaon, Nashik, Maharashtra, INDIA.

CORRESPONDENCE

Vaibhav G. Bhamare

Department of Pharmaceutics, K. K. Wagh College of Pharmacy, Nashik, Maharashtra, INDIA.

drvaibhavbhamare@gmail.com

Received: 29-09-2023; Revised: 05-11-2023; Accepted: 16-01-2024.

Volume 58, Issue 2 · pp. 519–525 · PUBLISHED 2024 · DOI: 10.5530/ijper.58.2.58

View on IJPER original site ↗

ABSTRACT

Background: Mammary cancer is the most common type of cancer and the leading cause of cancer-related death in women. Despite of numerous therapeutic options, cancer remains associated with high mortality. Traditional herb medicine has been found effective with minimal or no side effects. Materials and Methods: The leaves of Dolichandrone falcata Seem. (Bignoniaceae family) contains chrysin-7-rutinoside, flavanoids which possess Anti-cancer potential. The extract obtained from Soxhlet extraction process is then assessed against the chemical carcinogen (7,12-Dimethyl benzene anthracene) induced mammary carcinoma in rats. Results and Conclusion: The dose dependent study and statistical comparison with the help of graph pad prism, version 8.03 by one way ANOVA followed by Dunnett’s multiple comparison test has revealed that the significant reduction (p<0.05) is observed in the mammary tumor volume of the group treated with the extract and hence the Anti-cancer Potential of Dolichandrone falcata Seem. is justified.

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    Kapse, S. N., Bhamare, V. G., Amrutkar, R. D., Patil, R. N., Patil, V. R., & Talele, G. S. (2024). Assessment of Dolichandrone falcata Seem. Leaves for Anti-cancer Potential in Experimental Animal Models. Indian Journal of Pharmaceutical Education and Research, 58(2), 519–525. https://doi.org/10.5530/ijper.58.2.58