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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Novel EDC-Crosslinked Hydroxypropyl banana (Musa paradisiaca) starch as a Superdisintegrant for Enhanced Oral Delivery of Pioglitazone Hydrochloride in Orodispersible Tablets

Samyuktha Metta1,2, Srinivas Lankalapalli1★★ Corresponding author

  1. 1Department of Pharmaceutics, Gitam School of Pharmacy, GITAM University, Visakhapatnam, Andhra Pradesh, INDIA.
  2. 2Department of Pharmaceutics, Marri Laxman Reddy Institute of Pharmacy, Dundigal, Telangana, Hyderabad, INDIA.

CORRESPONDENCE

Srinivas Lankalapalli

Department of Pharmaceutics, Gitam School of Pharmacy, GITAM University, Visakhapatnam, Andhra Pradesh, INDIA.

slankala@gitam.edu

Received: 18-08-2025; Revised: 03-10-2025; Accepted: 24-12-2025.

Volume 60, Issue 2 · pp. 903–917 · PUBLISHED · DOI: 10.5530/ijper.20261872

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ABSTRACT

Background: Orally Disintegrating Tablets (ODTs) are gaining attention for improving patient compliance, especially in pediatric, geriatric, and dysphagic populations.Objective:This study aimed to develop and evaluate pioglitazone hydrochloride ODTs using EDC-Crosslinked Hydroxypropyl Banana starch (EDC-BS) as a novel, natural superdisintegrant. The objective was to assess the efficiency of EDC-BS in enhancing tablet disintegration and drug release compared to standard formulations containing cross povidone.Materials and Methods: EDC-BS was synthesized and characterized to confirm structural modifications and improved physicochemical properties. NMR and HRMS analysis validated effective crosslinking and hydroxyl propylation of banana starch. EDC-BS exhibited superior flowability, compressibility, and swelling capacity compared to native banana starch. Pioglitazone hydrochloride ODT formulations (F1-F10) were evaluated for thickness, hardness, friability, wetting time, disintegration, and in vitro drug release. Results:Formulations containing EDC-BS (F3 and F4) demonstrated enhanced disintegration efficiency and drug release profiles. Specifically, F3 achieved 96.36% drug release within 10 min and nearly 99.35% within 30 min, comparable to the standard formulation F9 containing crosspovidone. Furthermore, friability and hardness of F3 were within the acceptable range, confirming the mechanical stability of the tablets. Conclusion: In vitro evaluations highlighted the potential of EDC-BS as a cost-effective and biocompatible superdisintegrant, achieving results comparable to synthetic counterparts while addressing limitations such as cost and environmental concerns. This study establishes EDC-BS as a promising natural alternative for ODT formulations and provides a foundation for further exploration of its applicability in pharmaceutical development.

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    Metta, S., & Lankalapalli, S. (). Novel EDC-Crosslinked Hydroxypropyl banana (Musa paradisiaca) starch as a Superdisintegrant for Enhanced Oral Delivery of Pioglitazone Hydrochloride in Orodispersible Tablets. Indian Journal of Pharmaceutical Education and Research, 60(2), 903–917. https://doi.org/10.5530/ijper.20261872