Volume 60, Issue 2

Original Article(continued)

1. Article

   Hederagenin Shows Protective Effects Against Sodium Selenite-Induced Oxidative Stress and Cataractogenesis in Rats via Activation of Nrf2/HO-1 Pathway

   Min Yang, Li Meng, Zhanrong Zhang, Wenjun Chen, Yanlong Li

   pp. 663–672 · DOI: 10.5530/ijper.20262754 · 2026

   Background:Cataracts, a pervasive ocular condition, are defined by the progressive opacification of the crystalline lens, leading to a gradual decline in visual acuity and overall quality of life. This lens clouding obst…

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2. Article

   Conessine as A Novel Anti-Quorum Sensing Agent against Streptococcus mutans: An in vitro Analysis of Biofilm Inhibition

   Khloud H Alsaadi

   pp. 673–682 · DOI: 10.5530/ijper.20262947 · 2026

   Background: Dental caries concerns not solely the painful decay and eventual loss of the tooth but also significantly impacts an individual's physical, mental, and social health. The quest for potential Quorum Sensing (Q…

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3. Article

   Herb-Drug Interaction Evaluation on Concomitant Administration of IME-9 and Gliclazide in Preclinical Diabetic Rats

   Archana Kondibhau Thikekar, Asha Byju Thomas, Sohan Satyanarayan Chitlange, Avinash Purushottam Sanap, Ramesh Ramchandran Bhonde, Somdatta Yashwant Chaudhari

   pp. 683–698 · DOI: 10.5530/ijper.20267022 · 2026

   Background: Diabetes mellitus is the third most prevalent cause of mortality and morbidity globally. Several complementary or alternative therapies currently used to treat diabetes mellitus. IME-9 is a polyherbal prepara…

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4. Article

   Dose-Dependent Effects of Herbal Extract on Reproductive Health: Implications for Ovarian Structure, Organ Weight and Hormonal Balance in Female Rats

   Aiman Ammari, Ahmad Alhimaidi, Ramzi Amran, Hossam Aljawdah, Mutee Murshed, Ahmad Rady

   pp. 699–706 · DOI: 10.5530/ijper.20260951 · 2026

   Aim: Investigate the impact of varying dosages (100 mg and 250 mg/kg) of a specific herbal extract on reproductive parameters in female albino rats. Background: Herbal extracts are extensively utilized in traditional med…

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5. Article

   Cognitive-Enhancing and the Neuroprotective Propensity of Heartwood Caesalpinia sappan against D-Galactose- Induced Cognitive Impairments on Wistar Rats

   Pooja Rangenahalli Chidananda Murthy, Bharathi Doddla Raghunathanaidu

   pp. 707–716 · DOI: 10.5530/ijper.20260515 · 2026

   Background: We suggest evaluating heartwood Caesalpinia sappan's capacity to both protect neurons and improve cognition in Wistar rats by protecting them from the cognitive deficits caused by D-galactose. Objectives: The…

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6. Article

   Formulation and Evaluation of P-Naphthoquinone Casein Nanodispersions and their Antibacterial and Anticancer Activities

   Anitha Manikandan Duraikannu, Shanmugaprakash Muthusamy, Thangavel Pichaiapaa Rajesh

   pp. 717–728 · DOI: 10.5530/ijper.20261335 · 2026

   Aim/Background: This study focuses on the preparation, characterization, and evaluation of nanodispersion formulations of casein and PNQ for their antibacterial and anticancer activities. Casein micelles were used to sta…

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7. Article

   Sophoricoside Alleviates Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetes Mellitus in Rats

   Jie Yang, Lu Yan, Xinrong Zhang, Jiawei Zhang

   pp. 729–738 · DOI: 10.5530/ijper.20262129 · 2026

   Background: Diabetes mellitus, a chronic metabolic condition defined by chronic hyperglycemia, presents a major global health challenge with increasing prevalence and profound implications for individual’s well-being and…

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8. Article

   Formulation, Characterization, in vitro and MTT Cytotoxicity Evaluation of Pioglitazone HCl Films for Topical Administration

   Karishma Singh, Archana Mehrotra, Sobhna Singh

   pp. 739–748 · DOI: 10.5530/ijper.20262124 · 2026

   Aim: The main focus of the study was to create and analyze novel formulation to explore the potential of Pioglitazone HCl with Guar Gum, Chitosan and Sodium alginate for topical delivery and evaluate them. Materials and …

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9. Article

   Polydatin Induces Apoptosis in Thyroid Cancer TPC-I Cells by Regulating Apoptotic Proteins and Downregulating JAK/ STAT Pathway

   Xiao Zhao, Kai Gai, Bin Lin

   pp. 749–757 · DOI: 10.5530/ijper.20262136 · 2026

   Background: Thyroid cancer is relatively uncommon but its incidence has been steadily increasing over the past years. The etiology of thyroid cancer is multifaceted, with both genetic and environmental causes playing maj…

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10. Article

    Cardioprotective Effects of Piperlongumine against Doxorubicin-Induced Myocardial Infarction via Down-Regulating Cardiac Biomarkers in Rats

    Guo Xiong

    pp. 758–767 · DOI: 10.5530/ijper.20262259 · 2026

    Background:Doxorubicin, an extensively utilized antineoplastic agent, has been a significant contributor to the remarkable advancements in cancer treatment over the past several decades. However, the clinical usefulness …

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11. Article

    Formulation, Characterization, and Evaluation of Naringin-Loaded Phytosomal Gel and it’s in vivo Anti-Inflammatory Activity by Carrageenan Animal Model

    Satish Kavatagimath, Aqeeb Mevegar, Nayeem Khatib

    pp. 768–779 · DOI: 10.5530/ijper.20263075 · 2026

    Objective: The present study aimed to formulate, optimize, and evaluate a Naringin-loaded phytosomal gel using a 3² factorial design and to assess its anti-inflammatory activity. Materials and Methods: Phytosomes were pr…

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12. Article

    Combinatory Effects of Resveratrol and Curcumin in a Murine Model of Acuteon Chronic Liver Failure

    Jing Zhang, Xiaohong Wang, Qingchun Li, Wenqian Mou, Ting Zhu, Huanhuan Ba, Hamed Mirzaee, Shujuan Yang

    pp. 780–789 · DOI: 10.5530/ijper.20262571 · 2026

    Objectives: Acute-on-Chronic Liver Failure (ACLF) in cirrhosis patients involves rapid health decline, organ failure, and high mortality. This study aimed to assess the therapeutic effects of curcumin and resveratrol in …

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13. Article

    Peanut Skin Extract Attenuates Doxorubicin Induced Myocardial Infarction by Alleviating Cardiac Inflammation, Oxidative Stress and Histological Changes in Wistar Rats

    Mohd Wasim, Aamir Khan, Ashif Iqubal, Syed Ehtaishamul Haque

    pp. 790–797 · DOI: 10.5530/ijper.20267202 · 2026

    Background:Cancer treatment is a major global concern. The anticancer drugs being used are effective, but their uses are curtailed due to ground: toxicity that they produce. Doxorubicin is one of the most efficient anti-…

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14. Article

    Recent Advances in Pharmacotherapeutic Approaches for Alopecia areata: A Systematic Review of Clinical Trials from the Last Decade

    Ahmad Assiri

    pp. 809–829 · DOI: 10.5530/ijper.20262806 · 2026

    Background: Alopecia areata (AA) is an autoimmune disorder with diverse clinical presentations and limited universally effective therapeutic options. Over the past decade, numerous treatment strategies have emerged, incl…

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15. Article

    Wound Healing Potential of Curcumin and Colostrum- Loaded Liposomes in Diabetic Foot Ulcers

    Isha Chawla, Ishrat Zahoor, Seema Bansal, Anroop B Nair, Sumeet Gupta

    pp. 830–844 · DOI: 10.5530/ijper.20263371 · 2026

    Background: Diabetic Foot Ulcers (DFUs), a serious diabetes consequence, are caused primarily by hyperglycemia, oxidative stress, and chronic inflammation. This study aims to evaluate the therapeutic potential of liposom…

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16. Article

    Antimicrobial Activity of Acacia tortilis (Talha of Tindouf) against Bacteria and Fungi Isolated from Various Water Sources in the Elbayadh Region (Algeria)

    Moghtet Snoussi, Menad Najett, Benyagoub El Hassen, Hamed Djahira, Ait Saada Djamel

    pp. 845–851 · DOI: 10.5530/ijper.20265564 · 2026

    Background: In El Bayadh province, water is an essential resource for survival, prompting residents to settle in areas next to water springs that provide drinking water and support livestock. Water contamination poses a …

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17. Article

    Development and Validation of UPLC-PDA and UV Methods for the Quantitative Estimation of Ascorbic Acid (ASAC) in Pharmaceutical Formulations

    Wasim Ahmad, Nuzhat Banu, Ayaz Ahmad, Yousif Amin Hassan, Manal Surour, Rawan Rashad Aleid, Munfis Samir Patel, Sharell Lewis, Kamran Ashraf

    pp. 852–860 · DOI: 10.5530/ijper.20261506 · 2026

    Background: Vitamin C, also called Ascorbic Acid (ASAC), is a potent antioxidant that has a significant role in fighting infections and helps in healing wounds. Aim: Quantitative estimation of ASAC in formulations is of …

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18. Article

    Development and Validation of the Stability-Indicating RP-HPLC Method to Estimate Olaparib in Graphene Quantum Dot Nanoformulation Using Analytical Quality by Design (AQbD) Principles

    Pooja Rayanade, Archana Patil, Yadishma Gaude, Abhijit Salokhe, Priya Shetti

    pp. 861–868 · DOI: 10.5530/ijper.20261817 · 2026

    Introduction: This study aimed to develop and validate a reliable Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) method for the accurate quantification of Olaparib in a Graphene quantum dot nanoformulatio…

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19. Article

    Validated HPTLC Method for Accurate Measurement of Quercetin in Ficus benghalensis Linn. Bark Extract

    Sangita Kumari, Mahendra Pratap Chopra

    pp. 869–875 · DOI: 10.5530/ijper.20261891 · 2026

    Background:Quercetin is a key bioactive compound found in many plants and trees, popularly known for its ability to act as a potent antioxidant, reduce inflammation, decreases the risk of cancer, heart disease, and neuro…

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20. Article

    Coordination Scaffolds of Schiff Base Derived from Imatinib Amine: Synthesis, Spectroscopic and in vitro Biological Screening

    Prashant Gajera, Milan Vadodaria, Rahul Parmar

    pp. 876–883 · DOI: 10.5530/ijper.20260929 · 2026

    Aim:Imatinib amine based Schiff base heterochelates: Synthesis, Spectroscopic and in vitro biological screening. Materials and Methods: We acquired 2-Hydroxy-5-bromo benzaldehyde and 2-Hydroxy-5-nitro benzaldehyde from S…

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