Volume 60, Issue 2

Atharva Surendra Bhalerao, Sandeep Sonawane

pp. 460–466 · DOI: 10.5530/ijper.20260065 · 2026

Bioequivalence and bioavailability studies are vital components of the pharmaceutical industry, ensuring the safety, efficacy and interchangeability of generic drugs compared to their reference products. This comprehensi…

Karthikeyan Vetrivel, Murugappan Mahalingam, Vivekanandan Elango, Yusuf Mansor, Kshitija Dilip Nikam

pp. 467–473 · DOI: 10.5530/ijper.20260969 · 2026

The challenges of AMDD implantation across Southeast Asia are uniformly bringing medical device regulations better in line to improve the safety of patients while reducing regulatory hurdles and boosting regional trade. …

Daram Sushma Reddy, Gurupadayya Bannimath, Sruthi Kondru, Anupama Manepally, Manognya Kaveti, Rupshee Jain

pp. 474–484 · DOI: 10.5530/ijper.20261191 · 2026

The design and development of Stability-Indicating Assay Methods (SIAMs) are critical in the pharmaceutical industry to ensure the safety and efficacy of drug products throughout their shelf-life. These methods are speci…

Diksha Diwakar, Shahbaz Khan, Shivani lodha, Deepika Pal, Dinesh Kumar, Devesh Kumar, Alka Lohani

pp. 494–510 · DOI: 10.5530/ijper.20262132 · 2026

Background and Objectives: Huntington’s Disease (HD) is a rare neurodegenerative disorder marked by abnormal body movements, behavioral and psychiatric issues, and dementia. This inherited genetic disorder leads to cogni…

Manivasakam Prakash, Venkateswaramurthy Nallasamy, Senthil Venkatachalam, Anandharaj Govindaraj

pp. 485–493 · DOI: 10.5530/ijper.20261624 · 2026

The management of Helicobacter pylori (H. pylori) remains a complicated challenge worldwide. There is need for more effective optimised formulations with better therapeutic efficiency and less drug resistance. Rapid adva…

Juan Chen, Yingying Ji, Hongliang Qian, Jiayu Li, Chunmeng Sun, Xinran Wang, Cheng Jiang

pp. 511–520 · DOI: 10.5530/ijper.20266248 · 2026

Objectives: China is on the way to improving the education and training of outstanding pharmaceutical engineers. Still, the training of pharmaceutical engineers cannot meet the needs of innovative drug development and tr…

Bariki Rajasekhar, Haranath Chinthaginjala

pp. 521–531 · DOI: 10.5530/ijper.20260354 · 2026

Objectives: This study aimed to develop and characterize transdermal patches for Donepezil (DPZ) and Memantine (MMT) using a Box-Behnken Design (BBD), evaluating drug permeation at 8 hr, 16 hr, and 24 hr, with optimizati…

Mahalingan Kuppan, Vedamurthy Joshi, Muhammad Shahzad Chohan, Nagaraja Sreeharsha

pp. 532–538 · DOI: 10.5530/ijper.20263140 · 2026

Introduction: Poorly water-soluble drugs present challenges in development of formulation using conventional methods and are resulting in poor drug performance. Formulating these molecules into nanoparticles based drug d…

Abhishek Kanugo, Mohammad Adnan

pp. 539–549 · DOI: 10.5530/ijper.20265848 · 2026

Objectives:The benefits of the active ingredients are circumvented due to poor bioavailability or presystemic metabolism. Apixaban is an oral anticoagulant possessing high lipophilicity and bioavailability of less than 5…

Ramana Gangireddy, Shaik Aminabee, Kunderu Ravi Shankar, Raghavendra Kumar Gunda, Hari Krishna Gantasala, Akarsh Chowdary Kakarala, Kanamarlapudi Lakshmi Chandana, Chetan Mokkapati

pp. 550–557 · DOI: 10.5530/ijper.20266837 · 2026

Objectives: The purpose of the current study was to develop and evaluate Fast Dissolving Tablets (FDT) for the successful management of hypertension and heart failure utilizing the response surface technique. Bisoprolol …

Jianliang Qu, Wei Song, Abdullah A. Alarfaj, Abdurahman Hajinur Hirad

pp. 558–565 · DOI: 10.5530/ijper.20261971 · 2026

Objectives: Cisplatin is a widely used chemotherapeutic agent used in various cancers, but its clinical use is limited due to its dose-dependent toxicity, especially nephrotoxicity. Flavonoids are a class of natural comp…

Nur Akman, Ahmet Ufuk Komuroglu

pp. 566–574 · DOI: 10.5530/ijper.20266403 · 2026

Background: Diabetes Mellitus (DM) and Urinary Tract Infections (UTIs) are common conditions that, especially when occurring together, lead to significant morbidity. This study aimed to investigate the effects of Ciprofl…

Anuradha Niranjan Chivate, Niranjan Dattatray Chivate, Sudhir Sunil Patil, Shivsharan Basavraj Dhadde

pp. 575–581 · DOI: 10.5530/ijper.20266766 · 2026

Background:Conventional chemotherapy with Capecitabine is often associated with systemic toxicity, poor tumour selectivity, and suboptimal drug concentrations at tumour sites, limiting its therapeutic efficacy. Advanced …

Hani Alothaid

pp. 582–597 · DOI: 10.5530/ijper.20260852 · 2026

Background: The pursuit of effective cancer therapies hinges upon the identification and characterization of molecular targets amenable to precise modulation. Herein, we present a comprehensive investigation into the pot…

Yanlin Zhou, Yumei Shuai, Min Yang

pp. 598–603 · DOI: 10.5530/ijper.20260639 · 2026

Objectives: to investigate the protective mechanism of NLRP3 inflammatory bodies mediated by Dexmedetomidine (DEX) on renal injury in rats with hemorrhagic shock. Materials and Methods: 18 healthy SD rats were divided in…

Jiuhua Song, Qin Liu, Kai Shi

pp. 604–613 · DOI: 10.5530/ijper.20260713 · 2026

Objectives: To establish a method for determination of 11 components content to evaluate their quality and compare the difference between tuberous root and fibrous root of Ophiopogon japonicus by multivariate statistical…

Mahmoud Mohamed Morsy, Ahmed Yasser Azzam, Muhammed Amir Essibayi, Alsaleem Mohammed Abadi, Nasser Abdulmohsen Alsabaani, Safar Abadi Alsaleem, Waleed Abdulwahab Aldhabaan, Hana Jihad Abukhadijah, Mohamed Darwesh Morsy, Aayushi Aarav Garg, David Joseph Altschu

pp. 614–629 · DOI: 10.5530/ijper.20261194 · 2026

Introduction: Idiopathic Intracranial Hypertension (IIH) is a condition marked by elevated intracranial pressure without mass lesions or hydrocephalus, primarily affecting young obese women. Acetazolamide has been the st…

Ziye Wen, Tingting Zhang, Na Wang, Zeng Fan, Huihui Zhu, Zengxin Li

pp. 630–641 · DOI: 10.5530/ijper.20261984 · 2026

Background: Diabetes mellitus, a chronic metabolic disorder defined by persistent hyperglycemia, is a foremost global health issue. A significant complication of diabetes is the heightened risk of cardiovascular diseases…

Hassani Rym

pp. 642–651 · DOI: 10.5530/ijper.20262292 · 2026

Background Information: Osteosarcoma is the most common type of bone cancer, typically affecting children and young adults. It primarily develops in the long bones of the arms and legs. The banana (Musa spp) is widely po…

Jianlin Zhao, Miaomiao Fu, Yan Sun

pp. 652–662 · DOI: 10.5530/ijper.20262086 · 2026

Background: Asthma is a common and long-lasting respiratory disorder affecting more than 300 million individuals worldwide. Berbamine is a natural and highly active pharmacological compound extracted from the plant Berbe…