Article · Volume 60, Issue 2S · pp. s443–s461
Design and Development of Chitosan-Based Posaconazole Loaded Dry Powder by Using BBD
Sushil Kumar Singh1, Shyam Sunder Pancholi2
- 1Department of Pharmaceutical Technology, Ganpat University, Kherva, Mehsana, Gujarat, INDIA.
- 2Department of Pharmaceutics, School of Pharmacy and Technology Management (SPTM) SVKM’s NMIMS (Deemed to be University) Mukesh Patel Technology Park, Babulde, Shirpur, Dhule, Maharashtra, INDIA.
Abstract
Aim: Quality by Design (QbD)-Optimized Spray-Dried Microparticles (prepared by using spray drying process) of Posaconazole-Loaded Chitosan Nanoparticles (POS-CSNPs) for enhanced antifungal efficacy.Materials and Methods: Box-Behnken Design (BBD) a systematic design of experiments was implemented, to screen and optimize the formulation variables for the intended qualities.Results: Outcomes showed that POS-CSNPs have particle size (259.33±6.82 nm), Poly dispersity Index (0.192±0.010), zeta potential (-31.23±0.84 mV) and %Entrapment Efficiency (65.17±1.71). In vitro fungal study result showed the enhanced antifungal and higher fungicidal effect on Rhizopus oryzae strains.Conclusion: From the result it is concluded that the preparation of POS-CSNPs have higher anti-fungal effect on fungus strain.
Keywords: Box-Behnken design; Dry powder Inhaler; In vitro Fungal study; Nanoparticles; Posaconazole
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