Design and Development of Chitosan-Based Posaconazole Loaded Dry Powder by Using BBD
Sushil Kumar Singh1, Shyam Sunder Pancholi2★★ Corresponding author
- 1Department of Pharmaceutical Technology, Ganpat University, Kherva, Mehsana, Gujarat, INDIA.
- 2Department of Pharmaceutics, School of Pharmacy and Technology Management (SPTM) SVKM’s NMIMS (Deemed to be University) Mukesh Patel Technology Park, Babulde, Shirpur, Dhule, Maharashtra, INDIA.
CORRESPONDENCE
Shyam Sunder Pancholi
Department of Pharmaceutics, School of Pharmacy and Technology Management (SPTM) SVKM’s NMIMS (Deemed to be University) Mukesh Patel Technology Park, Babulde, Shirpur, Dhule, Maharashtra, INDIA.
Received: 04-08-2025; Revised: 29-09-2025; Accepted: 03-11-2025.
Volume 60, Issue 2S · pp. s443–s461 · PUBLISHED · DOI: 10.5530/ijper.20261364
ABSTRACT
Aim: Quality by Design (QbD)-Optimized Spray-Dried Microparticles (prepared by using spray drying process) of Posaconazole-Loaded Chitosan Nanoparticles (POS-CSNPs) for enhanced antifungal efficacy. Materials and Methods: Box-Behnken Design (BBD) a systematic design of experiments was implemented, to screen and optimize the formulation variables for the intended qualities. Results: Outcomes showed that POS-CSNPs have particle size (259.33±6.82 nm), Poly dispersity Index (0.192±0.010), zeta potential (-31.23±0.84 mV) and %Entrapment Efficiency (65.17±1.71). In vitro fungal study result showed the enhanced antifungal and higher fungicidal effect on Rhizopus oryzae strains. Conclusion: From the result it is concluded that the preparation of POS-CSNPs have higher anti-fungal effect on fungus strain.
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Singh, S. K., & Pancholi, S. S. (). Design and Development of Chitosan-Based Posaconazole Loaded Dry Powder by Using BBD. Indian Journal of Pharmaceutical Education and Research, 60(2S), s443–s461. https://doi.org/10.5530/ijper.20261364