Volume 60, Issue 2S

Review Article

1. Review

   Artificial Intelligence/Machine Learning in Pharma Analysis and Quality Control: A Real-World Upgrade

   Kishor Jain, Deepali Kadam, Sarathi Thakur, Pranali Dhole

   pp. s375–s384 · DOI: 10.5530/ijper.20264489 · Published

   Pharmaceutical analysis and quality control are now being transformed by Artificial Intelligence (AI) and Machine Learning (ML) through remarkable improvement in speed, accuracy, reliability, robustness of analysis metho…

2. Review

   Emerging Dynamics of the Medical Devices Sector in India

   Rakesh Kumar Tekade, Shailendra Saraf, Pallab Bhattacharya, Swarnalata Saraf

   pp. s385–s410 · DOI: 10.5530/ijper.20260002 · Published

   With a current compounded annual growth rate of more than 16% and a projected market value of 12 billion US$, the medical device industry in the Indian subcontinent alone is projected to reach a market size of over 50 bi…

3. Review

   Herbal Medicine in Gynecological and Obstetric Care: A Comprehensive Review of Clinical Trials

   Ali Hassan Khormi

   pp. s411–s429 · DOI: 10.5530/ijper.20260003 · Published

   This review comprehensively evaluates clinical trials assessing the efficacy and safety of herbal medicines and natural products in managing gynecological and obstetric conditions. With increasing interest in complementa…

4. Review

   Quality by Design (QbD) Approach in the Formulation of Liposomal Gel: A Review

   Attuluri V S Himabindu, Alla Seetha Devi

   pp. s430–s435 · DOI: 10.5530/ijper.20260963 · Published

   Liposomal gels represent an advanced drug delivery system that combines the benefits of liposomal encapsulation with the controlled release properties of gels, offering enhanced therapeutic efficacy, stability and patien…

5. Review

   Therapeutic Potential of Nanosilver Encapsulated Polysaccharide in Wound Healing

   Aniket Hajra, Moumita Chowdhury, Prosun Ganguly, Swarnakamal Bag

   pp. s853–s863 · DOI: 10.5530/ijper.20262151 · Published

   Chronic wounds create a major threat for an individual, which, if neglected, can cause severe infection in the form of sepsis. Therefore, early clinical diagnosis is very crucial to prevent further complications. Since c…

Original Article

1. Article

   Fabrication of Microneedle Patches of Indomethacin Using 3DP Technology

   Rohit Barua, Rupa Mazumder, Rakhi Mishra, Anjna Rani, Rashmi Mishra, Rajesh Kumar

   pp. s436–s442 · DOI: 10.5530/ijper.20264504 · Published

   Background:Indomethacin is a Nonsteroidal Anti-Inflammatory Drug (NSAID) that is frequently used for its pain-relieving, anti-inflammatory and fever-reducing properties. It is typically taken orally, but can also be admi…

2. Article

   Design and Development of Chitosan-Based Posaconazole Loaded Dry Powder by Using BBD

   Sushil Kumar Singh, Shyam Sunder Pancholi

   pp. s443–s461 · DOI: 10.5530/ijper.20261364 · Published

   Aim: Quality by Design (QbD)-Optimized Spray-Dried Microparticles (prepared by using spray drying process) of Posaconazole-Loaded Chitosan Nanoparticles (POS-CSNPs) for enhanced antifungal efficacy. Materials and Methods…

3. Article

   Development and Characterization of Sustained Release Solid Dispersions of Chlorzoxazone

   Shivakumar Hagalavadi Nanjappa, Ayesha Samreen, Avichal Kumar, Rushikesh Shinde

   pp. s462–s474 · DOI: 10.5530/ijper.20263331 · Published

   Objectives: The research aimed to develop Sustained Release Solid Dispersions (SRSDs) of Chlorzoxazone (COZ) to improve therapeutic efficacy and patient compliance. Materials and Methods: SRSDs were developed by the bott…

4. Article

   Development and Evaluation of Chitosan-Coated PLGA Nanoparticles of Canagliflozin for the Treatment of Hepatic Cancer

   Shadab Md, Eman Abdulmoen Abdullah Alharthi, Shahid Karim

   pp. s475–s489 · DOI: 10.5530/ijper.20263737 · Published

   Aim:The aim of the study was to develop, optimize and evaluate chitosan-coated Poly (Lactic-Co- Glycolic Acid) (PLGA) Nanoparticles (NPS) of Canagliflozin (CFZ) against the proliferation of liver cancer cells. Materials …

5. Article

   Design and Evaluation of Unidirectional Mucoadhesive Buccal Tablets of Diclofenac Sodium Using Different Polymers

   Pannerselvam Kavin, Dhasaiyan Mohankumar, Veintramuthu Sankar

   pp. s490–s496 · DOI: 10.5530/ijper.20263744 · Published

   Introduction: A mucoadhesive buccal drug delivery system is one of the novel methods to formulate the diclofenac sodium for increased bioavailability and bypass the hepatic first-pass metabolism, which would suppress the…

6. Article

   Formulation and Characterization of Tizanidine HCl Loaded Controlled Release Mesoporous Silica Nanoparticles (MSNs)

   Prateek Sahu, Sharad Prakash Pandey, Prakash Kumar Soni, Suresh Kumar Paswan

   pp. s497–s506 · DOI: 10.5530/ijper.20266522 · Published

   Introduction: Spasticity is a disorder in which continuous contraction of certain muscles leads to muscle stiffness. Tizanidine, a frequently prescribed skeletal muscle relaxant for spasticity treatment, exhibits a short…

7. Article

   Molecular Dynamics Characterization of the NCA-II Binding Site in Insect GABAA Receptors and Its Application to Ligand Screening

   Maria Salomé Gastaldi, Mariela Eugenia Sánchez-Borzone, Pran Kishore Deb, Supratik Kar, Katharigatta Narayanaswamy Venugopala, Daniel Asmed García, Virginia Miguel

   pp. s507–s521 · DOI: 10.5530/ijper.20264008 · Published

   Objectives: The rapid evolution of insecticide resistance emphasizes the necessity for developing innovative approaches to discover novel insecticides that are highly selective and effective. The second generation of GAB…

8. Article

   Development of an RP-HPLC Method for Simultaneous Estimation of Remogliflozin, Metformin and Teneligliptin in Tablet Formulation

   Dhwani Shah, Sejalben Patel, Ujashkumar Shah, Khooshbu Patel, Kunjal Vegad, Hirak Shah

   pp. s522–s532 · DOI: 10.5530/ijper.20260472 · Published

   Objectives: A cost-effective and reliable RP-HPLC method was developed and validated for the simultaneous estimation of Remogliflozin, Metformin and Teneligliptin in Pharmaceutical dosage form. Materials and Methods: Usi…

9. Article

   Phytofabrication of Magnetite Nanoparticles from Piper betle (L.) var. Mysore and Evaluation of Anti-Breast Cancer Potentials

   Ravikant Shekhar, Harischandra Sripathy Prakash, Nagaraja Geetha

   pp. s533–s540 · DOI: 10.5530/ijper.20261603 · Published

   Background:Breast cancer is a predominant disease around the world, with early diagnosis aiding in reducing the spread and recurrence. Plant-mediated nanoparticles have shown promising results in treatment. The current s…

10. Article

    Investigation of Nanosponge Based Delivery of Rutin and Brucine for Cancer Therapy

    Pallavi Sardana, Anroop B Nair, Sweta Dalal, Mani Shankar Bhattacharyya, Shery Jacob, Mohamed A Morsy, Katharigatta N Venugopala, Mahesh Attimarad, Tamer M Shehata, Rekha Rao

    pp. s550–s562 · DOI: 10.5530/ijper.20263680 · Published

    Background:Both rutin and brucine can suppress tumor growth mainly through the induction of apoptosis. This study aims to evaluate the potential of nanosponge based delivery to enhance the therapeutic efficacy of rutin a…

11. Article

    Flavonoid Ameliorates Anxiety in High Fat High Fructose diet Induced Insulin Resistance in Rats

    Prodeep Das, Prem Kumar Nanjundan, Sreeharsha Nagaraja, Girish Meravanige

    pp. s563–s574 · DOI: 10.5530/ijper.20263878 · Published

    Objectives: Literature review revealed that intake of high fat diet had a likelihood of causing metabolic syndrome and might be involved in causing anxiogenic symptoms. The current study was drafted to appraise hesperidi…

12. Article

    Antidiabetic Effect of Selenium-Laden Garlic (Allium sativum L.) in Streptozotocin-Induced Diabetic Rats

    Priyanka Keshari, Jyoti Mishra, Rita Singh Majumdar, Sachin Teotia

    pp. s575–s583 · DOI: 10.5530/ijper.20266701 · Published

    Background:Diabetes mellitus, being a prevalent and difficult-to-treat medical condition requires special concern from researchers and medicinal practitioners. Various research showed that Selenium (Se) and Allium sativu…

13. Article

    A Central Composite Design Optimized Diclofenac Potassium Loaded Niosomal Gel: Fabrication and Evaluation

    Harshini Krishnan Kandathil Veed, Edukulla Satheesh Kumar, Nithyapriya Vadakke Valappil, Ashwin Chandrasekhar Kotian, Prasenjit Prasad, Hindustan Abdul Ahad

    pp. s584–s596 · DOI: 10.5530/ijper.20261088 · Published

    Aim: The goal of this study was to create niosomal carriers for delivering diclofenac potassium through the skin, aiming to understand how these niosomal vesicles can improve skin penetration and absorption. Materials an…

14. Article

    Development Optimization, and Characterization of Solid Lipid Nanoparticles of Entacapone for Treatment of Parkinson Disease

    Kunal Mundada, Kanchan Chaudhari, Milind Wagh, Abhishek Kanugo

    pp. s597–s606 · DOI: 10.5530/ijper.20261245 · Published

    Introduction: Entacapone is recommended for treating Parkinson's disease. Objectives: Entacapone's high lipophilicity showed limited therapeutic efficacy in therapeutic doses. Moreover, the short half-life enabled freque…

15. Article

    Determination of Anti-Cancer and Photo-Aging Potential of Ripened Carica papaya Fruit Extract in in vitro Cell Line Models

    Manali Pradhan, Rajasekaran Raja, Rohit Sharma Sharma, Bharti Rathod, Debjani Dasgupta, Arindam Banerjee

    pp. s607–s616 · DOI: 10.5530/ijper.20261711 · Published

    Aim and Background: Carica papaya has been widely used in traditional medicine. However, the ripened papaya fruit remains underexplored regarding its potential as an anti-cancer and photo-aging aspect. Thus, our aim is t…

16. Article

    Combined Raft Formation-Interpenetrating Complex Approach to Reconstitutable Sustained-Release Suspension Development

    Pallavi Asaram Chandewar, Dilesh Jagdish Singhavi, Prachi Pradiprao Gedam, Nilesh Ashok Karande, Rajendra Onkarappa Ganjiwale

    pp. s617–s626 · DOI: 10.5530/ijper.20261811 · Published

    Background: The foundation of this work is the use of raft formation and Interpenetrating Polymeric Network (IPN) complexation techniques to create a reconstitutable sustained-release suspension of Diltiazem Hydrochlorid…

17. Article

    Synthesis and Evaluation of Mutual Prodrug of Mefenamic Acid and Etodolac with Sesamol for the Treatment of Alzheimer's Disease

    Prayaga Rajappan Krishnendu, Shebina Pareed Rasheed, Vibina Kaippollil, Arun Rasheed, Jibin Joy, Pattilthodika Suhail

    pp. s627–s637 · DOI: 10.5530/ijper.20261831 · Published

    Background: Epidemiological and clinical trial data suggest that NSAIDs can be used for managing Alzheimer's disease. This research area began with the observation of reduced incidence and progression of Alzheimer's dise…

18. Article

    Evaluation of Anti-Arthritic Effect of Red Sandalwood and Curcumin Combination (Orthorev Oil)® on Topical Application in Rats

    Jayshree Shriram Dawane, Priti Pravin Dhande

    pp. s638–s643 · DOI: 10.5530/ijper.20262483 · Published

    Background:Arthritis, a common and debilitating condition characterized by joint inflammation, pain, and stiffness, affects millions of individuals worldwide. The standard treatment for arthritis is effective, but often …

19. Article

    Emerging Trends and Conceptual Mapping in Network Pharmacology Research: A Bibliometric Analysis (2008-2023) Using VOSviewer

    Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Abdullah Farasani, Saleh M Abdullah, Saeed Alshahrani, Ahmad Assiri, Jobran M Moshi, Nizar A. Khamjan, Humaid Al-shamsi, Abrar Fahad Alshahrani, Syam Mohan

    pp. s644–s655 · DOI: 10.5530/ijper.20262593 · Published

    Background: Network Pharmacology (NP) aims to understand drug actions and their interactions with multiple targets using computational methods. Objectives: This provides a network-based approach to comprehensively invest…

20. Article

    Herbal Nanoparticle-Embedded Film-Forming Spray: A Novel Topical Delivery System for Vitiligo Management

    Madhuri H Rayabagi, Bijal Prajapati

    pp. s656–s668 · DOI: 10.5530/ijper.20262653 · Published

    Objectives: This study evaluated a topical film-forming spray designed to improve the skin permeation of curcumin and piperine-loaded nanoparticles, aiming to enhance therapeutic efficacy and reduce dosing frequency for …

21. Article

    Unmasking the Therapeutic Potential of a Bio-enhanced Phloretin Formulation: Formulation, Characterization, and Evaluation

    Niyamat M.A. Chimthanawala, Purnima D. Amin, Sadhana S. Sathaye

    pp. s669–s686 · DOI: 10.5530/ijper.20264165 · Published

    Introduction: Phloretin (PHL, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1- one), is a naturally occurring dihydrochalcone, exclusively found in apple fruit peels, leaves, and Manchurian apricots. It has treme…

22. Article

    Experimental Research of Ions in Wound Healing Via Film Forming Solution

    Ketura Kambampaty, Nagesh Chandrashekhar Setty, Suma Naduvinamani, Kartik Bhairu Khot, Sibghatullah Muhammad Ali Sangi, Sreeharsha Nagaraja, Girish Meravanige, Mohammed Monirul Islam, Pavan Kumar Sreenivasalu, Shahzad Chohan

    pp. s687–s698 · DOI: 10.5530/ijper.20264372 · Published

    Objectives: This study aimed to investigate the wound healing potential of Film Forming Solution (FFS) incorporated with Silver (Ag) and Copper Oxide (CuO) Nanoparticles (NPs). Materials and Methods:Ag NPs were synthesiz…

23. Article

    Comparative Evaluation of Co-Crystallization Methods for the Solubility Enhancement of Poorly Water-Soluble Drug of BCS Class II

    Harish K H, Leejoan D’souza, Sanatkumar Bharamu Nyamagoud, M Mahesh Yadav

    pp. s699–s709 · DOI: 10.5530/ijper.20264678 · Published

    Background: The practice of co-crystallizing 2 or more components has gained increasing popularity to create novel materials with enhanced performance and properties compared to those composed solely of pure components. …

24. Article

    Nasal Delivery of Nanoemulsion Containing a Synergistic Combination of Curcumin and Gefitinib for Brain Tumor Targeting

    Sagar Kishor Savale, Sachin Maroti Chandankar, Hitendra Shaligram Mahajan

    pp. s710–s720 · DOI: 10.5530/ijper.20265250 · Published

    Objectives:This study involves combination therapy of anticancer drugs (curcumin and gefitinib) as nanoemulsion and their application for treating human glioblastoma U373MG cell lines. Materials and Methods:Nanoemulsions…

25. Article

    High-Dose Ashwagandha Extract: A Toxicological Assessment in Male Wistar Rats Using a Dose-Dependent Approach

    Enas Sayed Gad, Afnan Omar Buobaid, Aisha Yousef ALfraih, Graham Mohammed Alanazi, Mariyayah Abdullah Alrashid, Maisaa Ibrahim Alessa, Nora Adel Alduhayyan, Rasha Naser Aldossari

    pp. s721–s727 · DOI: 10.5530/ijper.20263686 · Published

    Background/Aim: The rising utilization of Ashwagandha (Withania somnifera), a well-known adaptogen and herbal supplement, has prompted apprehensions over its safety at elevated dosages. This study examines the potential …

26. Article

    In vivo and in vitro Evaluation of Polymeric Gel Loaded with Biologically Synthesized Black Tea and Baliospermum solanifolium Silver Nanoparticle

    Sarika Nikam, Shilpa Chaudhari, Priyatama Powar

    pp. s728–s738 · DOI: 10.5530/ijper.20266071 · Published

    Aim: The overall objective of the study was to synthesise and assess a polymeric gel that contained biologically synthesised Silver Nanoparticles (AgNPs). Materials and Methods:AgNPs were produced through the reduction o…

27. Article

    Design and Development of Simple Liquid Chromatographic Technique for the Rapid Determination of Ruxolitinib (RUXO) in Bulk Drugs along with Characterization of Forced Degradation Studies

    Sarangadhara Sahu, Susanta Kumar Panda, Sudhir Kumar Sahoo, Madhusmruti Khandai, Amaresh Prusty

    pp. s739–s747 · DOI: 10.5530/ijper.20262561 · Published

    Objectives:The motive behind this work is to develop a simple, rapid, accurate, and precise High-Performance Liquid Chromatography (HPLC) method for determining Ruxolitinib (RUXO) in bulk drugs and to study drug degradat…

28. Article

    To Evaluate the Affinity of Chlorogenic Acid and Ferulic Acid towards PPAR-Γ and Glutathione S-Transferase Omega-1 Complex with the Docking Simulation and their Pharmacological Activities by Using their Formulation

    Pallavi Patil, Neha Shegokar, Vitthal Chopade, Sandhya Bagde

    pp. s748–s757 · DOI: 10.5530/ijper.20266738 · Published

    Objectives: The aim of this study was to perform molecular docking and ADMET analyses of ferulic acid and chlorogenic acid. Through molecular docking, we have observed the receptor affinity, specifically targeting the PP…

29. Article

    Screening, Optimization and Production of Uricase from a Novel Actinomycete Isolate A85

    Anand Kumar Dakuri, Girijasankar Guntuka, Sowjanya Gurugubelli, Mobeen Shaik, Sandeep Venkata Chalapathi

    pp. s758–s767 · DOI: 10.5530/ijper.20264421 · Published

    Background: Uricase is used to diagnose the presence of uric acid in biological fluids as well as to cure gout. Uric acid concentrations in -biological fluids are elevated by several medical disorders. Chronic renal diso…

30. Article

    Formulation and Evaluation of Nanocrystals of Hydrochlorothiazide

    Kumar Mithun, Kumar Anoop, Pathak Divya

    pp. s768–s775 · DOI: 10.5530/ijper.20264915 · Published

    Aim/Background:Hydrochlorothiazide (HTZ) is a diuretic derivative and used as an antihypertensive agent with low bioavailability (around 60%) due to impaired dissolution rate. Further, excretion of HTZ is high due to rap…

31. Article

    Optimizing Tumor-Targeting Drug Delivery of Potent Anti-Cancer Drug Using Doe-Guided Solid Lipid Nanoparticle Formulation: In vitro Cell Line Studies and Histopathological Analysis

    Ramineni Sunitha, Praveen Sivadasu, Pathange Bharghava Bhushan Rao, Raghavendra Kumar Gunda

    pp. s776–s793 · DOI: 10.5530/ijper.20261953 · Published

    Background:Lapatinib Ditosylate emerges as a notable contender; it functions as potent selective dual tyrosine kinases ErbB-2 and EGFR inhibitor and it is a class-II drug. The present work focuses on the development of L…

32. Article

    Risk Factor Analysis in Diabetes and Hypertension Patients from Odisha, India: A Cross-Sectional Study

    Prabhudatta Mohapatra, Ashrumochan Debata, Rohan Kumar Pradhan, Karmajeet Rath, Swayamsidha Mangaraj, Mihir Kumar Kar, Durga Madhab Kar

    pp. s794–s804 · DOI: 10.5530/ijper.20262353 · Published

    Objectives:This study aims to investigate the incidence of poor glycemic control among elderly diabetic individuals with hypertension in urban areas of Odisha, India. This observational cross-sectional study was conducte…

33. Article

    In silico and in vitro Investigation of Osteogenesis Potentiality of Smilax china Hydro Alcoholic Root Extract on Human Osteoblast-like Cell Line (Saos2)-A Novel Approach

    Hafiz A. Makeen, Mohammed Albratty

    pp. s805–s814 · DOI: 10.5530/ijper.20263810 · Published

    Background: Osteoporosis is a skeletal illness characterised by the breakdown of bone tissue's micro-architecture, which increases the risk of fractures by making bones more brittle. Nowadays, the herbal based therapies …

34. Article

    Formulation and Evaluation of a Bromelain-Loaded Nanoemulgel for Effective Acne Treatment

    Archana S Patil, Pratik Ugare, Arpana Patil, Sheetal Patil, Rajashree Masareddy

    pp. s815–s825 · DOI: 10.5530/ijper.20261446 · Published

    Aim: This study aimed to design, optimize, and evaluate a bromelain-infused nanoemulgel to enhance its transdermal delivery and improve therapeutic outcomes in the management of Acne vulgaris. Background: Acne vulgaris r…

35. Article

    Optimization of Ganciclovir-Loaded Nanoparticles for Ocular Delivery by Utilizing Box-Behnken Design

    Shalu Verma, Divya Juyal

    pp. s826–s838 · DOI: 10.5530/ijper.20262668 · Published

    Aim: The study aimed to optimize Ganciclovir-loaded nanoparticles for ocular delivery by evaluating the relationship between experimental data and Design factors. Materials and Methods:The nanoparticles were developed us…

36. Article

    Neuroprotective Effects of Eupatorin against Valproic Acid-Induced Autism-Like Phenotypes in Zebrafish Embryos

    Abdullah Farasani

    pp. s839–s852 · DOI: 10.5530/ijper.20264630 · Published

    Purpose:Autism Spectrum Disorder (ASD) is a neurodevelopmental condition often linked to oxidative stress and dysregulated apoptosis. Valproic Acid (VPA), a known teratogen, induces ASD-like behavioral and morphological …

1. Article

   Artocarpus heterophyllus Lam.: Pharmacognostic, Phytochemical Study and Its Evaluation for Antimitotic Potential by Modified Allium cepa Bioassay

   Vijaya Verma, Pallavi Wadibhasme, Nilesh Banarase, Yogesh Pounikar

   pp. s541–s549 · DOI: 10.5530/ijper.20263421 · Published

   Background and Objectives: Artocarpus heterophyllus Lam. commonly known as jack tree reported to have various traditional applications, attributed by every part, for the treatment of various ailments. Although various re…