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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Development and Evaluation of Chitosan-Coated PLGA Nanoparticles of Canagliflozin for the Treatment of Hepatic Cancer

Shadab Md1★, Eman Abdulmoen Abdullah Alharthi1, Shahid Karim2★ Corresponding author

  1. 1Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, SAUDI ARABIA.
  2. 2Department of Clinical Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, SAUDI ARABIA.

CORRESPONDENCE

Shadab Md

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, SAUDI ARABIA.

shaque@kau.edu.sa

Received: 18-07-2025; Revised: 24-09-2025; Accepted: 03-11-2025.

Volume 60, Issue 2S · pp. s475–s489 · PUBLISHED · DOI: 10.5530/ijper.20263737

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ABSTRACT

Aim:The aim of the study was to develop, optimize and evaluate chitosan-coated Poly (Lactic-Co- Glycolic Acid) (PLGA) Nanoparticles (NPS) of Canagliflozin (CFZ) against the proliferation of liver cancer cells. Materials and Methods: The PLGA NPs and chitosan-coated PLGA NPs containing CFZ was optimized keeping CFZ:PLGA ratios and PVA levels as independent variables and mean Particle Size (PS), Polydispersity Index (PDI), Zeta Potential (ZP), and percent Entrapment Efficiency (EE) as the responses. Results:The optimized CFZ-PLGA-NPs had PS, PDI, ZP, and EE values of 159 nm, 0.149, -36.5 mV, 84.8%, respectively. The concentration of chitosan coating (0.25%) was found to be optimum providing a PS of 277±23 nm, PDI of 0.241±0.011, ZP of 57.2±0.67 mV, and EE of 80.5±1.78%. The electron microscope images, FTIR spectra, and DSC thermograms confirmed the identity of individual components and the amorphous nature of CFZ in the C-CFZ-PLGA-NPs. The in vitro CFZ release from C-CFZ-PLGA-NPs (80.9±1.2%) was significantly higher than that from CFZ dispersion (25.9±1.4%) when studied for 48 h. The cell viability assay demonstrated significant enhancement of cytotoxicity of C-CFZ-PLGA-NPs against HepG2 cells compared to pure CFZ treatments. The C-CFZ-PLGA-NPs were found to be stable when tested for storage stability at 4ºC for 90 days. PS, PDI, and ZP remained stable during the entire study period. Conclusion: C-CFZ-PLGA-NPs can be considered potential candidates for further studies in providing a commercially viable, stable, and effective system for the delivery of CFZ

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    Md, S., Alharthi, E. A. A., & Karim, S. (). Development and Evaluation of Chitosan-Coated PLGA Nanoparticles of Canagliflozin for the Treatment of Hepatic Cancer. Indian Journal of Pharmaceutical Education and Research, 60(2S), s475–s489. https://doi.org/10.5530/ijper.20263737