Volume 60, Issue 1

Revolutionizing Dental Practice: A Review of Innovations in Dental Materials

Suankit Ashok Harane, Mahesh Kashinath Patil, Vinita Vijay Kale, Milind Janrao Umekar

pp. 1–13 · DOI: 10.5530/ijper.20261637 · Published 2026

Dental materials are essential in modern dentistry, facilitating the diagnosis, treatment, and prevention of oral diseases. They are utilized in restorative, prosthetic, preventive, endodontic, and orthodontic procedures…

3D Bioprinting Potential Technology for Drug Delivery

Lakshmi Sampada Jayanthi, Haranath Chinthaginjala, Sameer Tadipatri, Suryaprathap Thippeswamy Gari, Nishanth Goud Gadwala Vajagouni

pp. 14–27 · DOI: 10.5530/ijper.20261646 · Published 2026

The advent of three-Dimensional (3D) bioprinting offers transformative opportunities in tissue engineering, enabling the precise fabrication of functional tissues and organs for medical and research applications. This st…

A Review of Game-Based Learning in Higher Education: Exploring Escape-Room Methodologies in Educational Settings

Sui Ling Janet Tan, Intan Nurul Annisha Binti Suhaili, Siti Nur Maisarah Binti Adnan, Nor Syahira Binti A Ham Suri, Ahmad Nabil Mukhlis Bin Ahmad Zaky

pp. 28–36 · DOI: 10.5530/ijper.20261516 · Published 2026

Conventional teaching approaches that lack interactive techniques may hinder the effectiveness of knowledge acquisition and student engagement. Innovative teaching approaches are essential to engage with tech-savvy Gener…

Compromised Medical Products A Scoping review of Quality, Safety and Efficacy Concerns

Shailee Dewan, Nikhil Narayan Naik, Pranagini Artham, Manthan Dilipkumar Janodia, Pradeep Manohar Muragundi

pp. 37–53 · DOI: 10.5530/ijper.20261930. · Published 2026

Background: In 2011, the World Health Organization (WHO) coined the term substandard/ spurious/falsely labelled/falsified/counterfeit (SSFFC) to describe medical products that compromise quality, safety, and efficacy. De…

The Potential Effect of Plant Based Antioxidants in Breast Cancer Prevention and Treatment

Chaojia Shi, Gang Fang, Huanhuan Song, Xinyuan Qin, Yueting Liu, Yuxuan Luo, Wenhui Li, Zhiyong Cao, Jingjing Li, Xiaoting Fan

pp. 54–62 · DOI: 10.5530/ijper.20265693 · Published 2026

Breast cancer is the most common cause of death among women worldwide. According to the 2024 Cancer Statistics report, it has surpassed lung cancer as the most frequently diagnosed cancer around the world. Oxidative stre…

Integrating Diversified Graphical Thinking Mode into the Teaching Practice of Inorganic Chemistry

Qing-Kun Shen, Qun-Xiang Ren, Li-Li Sui, Tian Luan, Jin Wang

pp. 63–72 · DOI: 10.5530/ijper.20256458 · Published 2026

Background: Inorganic chemistry holds significant importance in pharmacy major as it serves as the foundation for subsequent professional courses. However, students exhibit varying learning conditions during the teaching…

Formulation Development and Evaluation of Atorvastatin Soy Lecithin Solid Dispersion A Promising Approach for Solubility Enhancement

Madhuri Lale, Jayshree Taksande, Keshav Hirave, Nupur Jaiswal, Radhika Gupta, Mohammad Qutub, Amol Tatode, Milind Umekar

pp. 73–82 · DOI: 10.5530/ijper.20262703 · Published 2026

Background: Hyperlipidaemia remains a significant contributor to cardiovascular disorders, with statins being the primary therapeutic agents for its management. However, the clinical efficacy of these drugs, particularly…

Optimizing Ultrasonic Extraction of Antioxidants and Polyphenols in Five Indigenous Remedial Plants Using Box-Behnken Design Combined with Response Surface Methodology

Tripathy Amrutanand, Maged Alkanad, Nischith Sirawase Shankar, Annegowda Hardur Venkatappa

pp. 83–95 · DOI: 10.5530/ijper.20260925 · Published 2026

Aim/Background: This study aimed to optimize the ultrasonic extraction of antioxidants and polyphenols from five indigenous medicinal plants Cassia auriculata, Celastrus paniculatus, Moringa concanensis, Murraya koenigii…

Formulation Development and Evaluation of Transferosomal Gel Using Trifarotene

Anuradha Prajapati, Muskan Tandel, Sachin B Narkhede, Neha Desai, Shailesh Luhar, Kantilal Narkhede

pp. 96–105 · DOI: 10.5530/ijper.20261010 · Published 2026

Background: Trifarotene (TFT), a retinoid commonly used for acne treatment, suffers from poor water solubility, limiting its effectiveness and increasing the risk of side effects. Enhancing its bioavailability and provid…

Preparation and Characterization of Eudragit L100/S100 Coated Zafirlukast Pellets for Chronotherapy

Ponnaganti SS Prasanna Kumar, Lankalapalli Srinivas

pp. 106–113 · DOI: Original Article · Published 2026

Background: The initial goal of the current research investigation was to design, develop oral formulation of Pulsatile Drug Delivery Systems (PDDS) for Zafirlukast with aim of treatment for asthma. Delivery system was d…

Formulation Development and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Azelnidipine for Hypertension

Rutik Jukti, Abhishek Kanugo

pp. 114–123 · DOI: 10.5530/ijper.20266497 · Published 2026

Introduction/Objectives: Azelnidipine is a novel calcium channel blocker usually recommended for the management of an upsurge in blood pressure. The beneficial activity is circumvented because of extreme lipophilicity (L…

Optimization of Pitavastatin Calcium and Micronized Fenofibrate Bi-layer Tablets Using Quality by Design

Jun Woo Park, Il Dae Song, Jae Seon Kang, Kang Min Kim

pp. 124–131 · DOI: 10.5530/ijper.20260939 · Published 2026

Background and Purpose: This study aimed to develop bilayer tablets containing pitavastatin calcium and micronized fenofibrate. Materials and Methods: For optimization of manufacturing based on preliminary formulation re…

Formulation, Optimization and in vitro Evaluation of Ibuprofen-Loaded Cubosomal Nano-Formulation for Effective Topical Delivery

Sujay Hulyalkar, Rachana Pockle, Siddarth Usulkar, Panchaxari Dandagi

pp. 132–139 · DOI: 10.5530/ijper.20264232 · Published 2026

Objectives: This research aims to formulate and assess an Ibuprofen-loaded cubosomal gel that would improve the drug's skin absorption and minimize its oral adverse effects. Hence, clinically relevant drug concentration …

Development and Assessment of Mucoadhesive Buccal Tablets Containing Dapsone: A Pharmaceutical Innovation

Kondapuram Parameshwar, Raghavendra Kumar Gunda, Shaik Harun Rasheed, Venugopal Muralidharan, K Ravi Shankar

pp. 140–149 · DOI: 10.5530/ijper.20266059 · Published 2026

Objectives: This research involved developing buccal tablets with the drug Dapsone, using varying amounts of three substances: Carbopol 934, Hydroxypropyl Methylcellulose, and Sodium Carboxymethyl Cellulose. Materials an…

Design and Characterization of Camptothecin Loaded Colloidosomes for the Effective Treatment of Lung Cancer

Swapnil Harale, Kaivalya Mirajakar, Sunil Galatage, Arehalli Manjappa, Mrityunjaya Patil, Kishori Sutar, Rushikesh Katkar, Durgacharan Bhagwat, Lakshmanarao Potti, Rahul Trivedi, Gourisankar Kandukuri, Prajyot Kumbhar, Kranti Bille, Ankush Patil

pp. 150–162 · DOI: 10.5530/ijper.20260528 · Published 2026

Background: Among the various cancers, lung cancer is the second leading cause of mortality after the breast carcinoma. Camptothecin (CPT) has broad spectrum anticancer potential used in the effective management of cance…

Chrysin Ameliorates Mycoplasma pneumonia Induced Pneumonia in Mice by Down-Regulating Inflammatory Response

Qiong Gao, Jiao Jiao, Tian Tian, Yanping Shi, Jun Li

pp. 163–171 · DOI: 10.5530/ijper.20261592 · Published 2018

Background: Mycoplasma pneumonia, a major respiratory infection characterized by inflammation of the lungs, poses a substantial global health concern, particularly among vulnerable populations such as the elderly, immuno…

Anticancer Effects of Silver Nanoparticles Synthesized from Eupatorium adenophorum Extract in Animal Model: Impact on Tumor Growth, Apoptotic Markers and Organ Biomarkers

Shilpa Rana, Uddipak Rai, Vineet Kumar, Pankaj Pant, Yogita Ale

pp. 172–182 · DOI: 10.5530/ijper.20261036 · Published 2026

Evaluation of Polyherbal Preparation Containing Aegle marmelos and Saraca asoca Plants for Screening of Urolithiasis Disease

Pooja Pooja, Avijit Mazumder, Saumya Das

pp. 183–190 · DOI: 10.5530/ijper.20261403 · Published 2018

Aim: To evaluate the efficacy of a polyherbal formulation in alleviating urolithiasis induced by ethylene glycol in a rat model and to assess its effects on biochemical and histopathological parameters. Background: Uroli…

Osthenol Shows Cardioprotective Activity Against Isoproterenol-Induced Myocardial Infarction in Rats via Inhibiting Oxidative Stress and Inflammation

Liu Wei, Wen Quanbao

pp. 191–199 · DOI: 10.5530/ijper.20261966 · Published 2018

Background: Myocardial Infarction (MI) is a devastating cardiovascular complication that develops when blood flow to a region of the myocardium is obstructed, resulting in cardiomyocyte necrosis and loss of contractile f…

Protective Effects of Cassia fistula Linn. On Reproductive Organs Weight and Tissue Biochemical Markers in Streptozotocin-Induced Diabetic Male Rats

Ram Niwas Jangir, Gyan Chand Jain, Aditya Jain

pp. 200–208 · DOI: 10.5530/ijper.20261582 · Published 2026

Objectives: This study aims to evaluate the impact of hydroethanolic extract from Cassia fistula pods on reproductive organs weight and biochemical markers within reproductive tissues in experimental diabetic rats. Mater…

Effect of Carvacrol in Attenuating the TNF-α Induced Sarcopenia

Ali Mufraih Albarrati, Rakan Ibrahim Nazer

pp. 209–218 · DOI: 10.5530/ijper.20262945 · Published 2026

Background: Sarcopenia is a condition characterized by muscle loss, which is accompanied by inflammation, oxidative stress, and mitochondrial dysfunction. The current treatment of sarcopenia is insufficient in handling t…

Development and Characterization of Catechin-Loaded Self-Nanoemulsifying Drug Delivery System: Pharmacokinetics, Toxicity Assessment, and in vivo Anti-Ulcer Activity Evaluation

Rashmi Pathak, Phool Chandra

pp. 219–236 · DOI: 10.5530/ijper.20261584 · Published 2026

Purpose: This research aimed to prepare catechin-loaded SNEDDS that would improve the oral therapeutic efficacy of catechin. Materials and Methods: Catechin-SNEDDS was prepared and characterized using emulsification time…

Effect of Theobroma cocoa Extract on Olanzapine-Induced Metabolic Syndrome in Rats

Varsha Patole, Sanjay Bhawar, Santosh Dighe, Rajashree Ghogare, Manisha Sonawane

pp. 237–246 · DOI: 10.5530/ijper.20261703 · Published 2026

Objectives: This study examined the effects of Theobroma cocoa hydro-alcoholic Extract (TCE) on the metabolic syndrome that rats developed because of olanzapine. Materials and Methods: Dry cocoa powder was macerated in 8…

Anti-nociceptive and Anti-inflammatory Effects of Withanone in Various Nociception and Inflammation-Induced Murine Model

Fengfeng Wang, Yunxia Zhu

pp. 247–257 · DOI: 10.5530/ijper.20261166 · Published 2026

Background: Pain is an unpleasant sensation that may result from severe or harmful stimuli. It serves as an indication that there may be a problem within the body and it can aid in ensuring the protection. Pain is a ubiq…

Neuroprotective Effect of Inula racemosa on Chronic Stress-Aluminum Chloride Induced Memory Deficits

Bhagya Venkanna Rao, Kanimozhi Loganathan, Sushma Raju, Ramya Vasudev

pp. 258–269 · DOI: 10.5530/ijper.20261730 · Published 2026

Introduction: Alzheimer's Disease (AD) is characterized by cognitive impairment resulting from the accumulation of amyloid beta and tau plaques, reduced Brain-Derived Neurotrophic Factor (BDNF) expression, neuronal death…

Solid Lipid Nanoparticles of Resveratrol: Formulation, Characterization and In vitro Anti-Inflammatory Studies

Vedanshu Malviya, Altaf Khan, Sachin Padole, Vaibhav Thakare, Tushar Gajbhiye

pp. 270–282 · DOI: 10.5530/ijper.20261895 · Published 2026

In vitro Anti-oxidant, Antimicrobial, in silico Molecular Docking Analysis, and Phylogenetic Analysis of Anoectochilus elatus

Sathishkumar Muthusamy, Selvi Sellappan, Palanisamy Arulselvan, Abdullah A Alarfaj

pp. 283–293 · DOI: 10.5530/ijper.20262104 · Published 2026

Background: Medicinal plants have long been valued for their therapeutic properties, offering a rich reservoir of bioactive compounds. Across millennia, diverse cultures worldwide have developed intricate systems of trad…

Antioxidant and Anti-Inflammatory Efficacy of Dipsacoside B in Ameliorating Myocardial Infarction in an in vivo Model

Xiao Han, Fang Chen, Jinying Zhao

pp. 294–304 · DOI: 10.5530/ijper.20262103 · Published 2018

Background: Myocardial Infarction (MI) is a severe coronary ailment associated with a great risk of mortality, often contributing to sudden cardiac death. Cardiovascular diseases account for approximately 32% of global d…

Morpho-Genetic Variability in Phytochemical Composition and Essential Oils of Three Common Lavandula Species Cultivated in Van, Türkiye

Lutfi Nohutcu, Murat Tuncturk, Ruveyde Tuncturk, Ezelhan Selem

pp. 305–311 · DOI: 10.5530/ijper.20261158 · Published 2026

Background: Lavandula sp. is a valuable plant species as ornamental plant with beautiful inflorescence and aromatic plant with high yield of essential oil. Lavender is mostly produced in Europe, the Middle East, Asia, No…

Monoterpene Α-Pinene Alleviates Diabetic Retinopathy in Rodent Model via Attenuating Hyperglycemia Induced VEGF Signaling

Xiao Dong, Zhanrong Zhang

pp. 312–321 · DOI: 10.5530/ijper.20261413 · Published 2018

Background: Diabetic Retinopathy (DR) has emerged as a significant global health issue that requires urgent and collaborative action to tackle. As the leading causes of preventable blindness, DR predominantly impacts adu…

PPAR-γ and GLUT-4 Mediated Insulin Sensitizing Action of Paspalum scrobiculatum Grains; An In vivo and In silico Study towards Validating it as a Long-Term Therapy for Type 2 Diabetes

Jyothi Reddy Gangavaram, Gourelly Latha, Mangari Pooja, Somanjeri Nithya, Allagadda Rajasekhar, Kesavan Bhaskar Reddy

pp. 322–335 · DOI: 10.5530/ijper.20261128 · Published 2026

Purpose: Insulin Resistance (IR) usually results from a decline in levels of critical signalling proteins, their functional modifications, or both. Food and drinks rich in fat, energy and/or sugars increases the risk of …

Exosomal miR-34b-5p from Bone Marrow Mesenchymal Stem Cells Attenuates Spinal Cord Injury via MAPK/PI3K/ AKT Pathway Modulation

Ming Cheng, Long Jia, Tao Yang, Xue Zhou, Ling Zeng, Hua Lu, Nianchi Wen, Benxiang He

pp. 336–347 · DOI: 10.5530/ijper.20262022 · Published 2018

Introduction: Bone Marrow Mesenchymal Stem Cells (BMMSCs) promote Spinal Cord Injury (SCI) recovery via exosomes containing bioactive molecules. This study examined the role and mechanisms of BMMSC-derived exosomes overe…

Atractylenolide III Relieves Diphenoxylate-Induced Constipation via Gut Microbiota and Bile Acid Pathway Modulation

Simin Chen, Zhibin Zhang, Jun Pang, Lina Guan, Qingfeng Wu, Qiuxiao Wang, Qian Li, Xuegui Tang

pp. 348–360 · DOI: 10.5530/ijper.20251336 · Published 2026

Aim/Background: An imbalance of intestinal flora and its fermentation products can disrupt intestinal peristalsis and lead to constipation. This study aimed to investigate how Atractylenolide III (ATL-III) may enhance co…

Molecular Docking, Synthesis and Determination of Anticancer Potential of Novel Pyrimidine Derivatives: In vitro and in silico Characterization

Machhindra Holam, Sunil Galatage, Supria Gaud, Sanika Kumbhar, Aishwarya Devaru, Saniya Inamdar, Sushma Dokare

pp. 361–373 · DOI: 10.5530/ijper.20260733 · Published 2018

Background: Lung and colon carcinoma are leading causes of mortality among all cancers and cases are increasing drastically. Chemotherapy plays vital role in the treatment of carcinoma and a new series of pyrimidine hete…

In vitro and in silico Analysis Alnustone Induced Anticancer Effects in Human Gastric Cancer

Na Xu, Yixiu Zhao

pp. 374–382 · DOI: 10.5530/ijper.20251185 · Published 2026

Background: A growing number of people are at risk for gastrointestinal disorders due to dietary modifications and excessive consumption of processed food. Gastric Cancer (GC) ranks fifth in terms of frequency of diagnos…

Targeting Alpha-Amylase: Discovering Novel Inhibitors through E-Pharmacophore Modeling and in vitro studies

Norah Saeed Al-Zahrani, Basiouny El-Gamal, Mohamed Abd Ellatif, Mohamed Babiker Abd Elrouf, Alam Eldin Musa Mustafa Musa, Niemat Mohammed Tahir Ali, Marya Ahsan, Ayaz Khurram Mallick, Ayyub Ali Patel, Safaa Omer, Muniera Mohieldeen, Hagar Mohamed Mohamed, Marwa Saeed, Safa Mousa Al-Haider, Mohammed Abdullah Alshehri

pp. 383–392 · DOI: 10.5530/ijper.20261204 · Published 2018

Background: Diabetes mellitus is a metabolic disorder affecting millions worldwide, with prevalence continuing to rise globally. A major therapeutic challenge is controlling postprandial blood glucose spikes that contrib…

Deciphering Key Protein Targets, Hub Gene Networks, Signaling Pathways and in silico Docking Studies of Artemisinin in Human Lung Carcinoma

Xin Sheng, Dandan Sheng, Ruiqing Xing

pp. 393–409 · DOI: 10.5530/ijper.20261248 · Published 2018

Background: Artemisinin has been reported to exert potent anticancer effects in diverse cancers, but its mode of anticancer action is not fully understood. Objectives: This study involved network pharmacology, bioinforma…

Investigatıon of the Protective Effect of Hydrogen Sulphide Donor Sodium Hydrosulphide and Sulfurized Apricot on Experimental Acute Kidney Injury Induced by Cisplatin in Rats

Nihan Celikoz, Yakup Yilmaztekin, Ozlem Cankaya, Aslı Taslidere, Rumeyza Hilal Datli, Ayse Burcin Uyumlu, Metin Fikret Genc, Kadir Batcioglu

pp. 410–420 · DOI: 10.5530/ijper.20261390 · Published 2018

Background: In the present study, we aimed to investigate the protective effect of Hydrogen sulfide (H2S) donor Sodium Hydrosulphide (NaHS) and Sulfurized Apricot (SA) on experimental acute kidney injury induced by cispl…

Bilobetin Shows Immunomodulatory and Chemopreventive Activities in Benzo(a)pyrene-Induced Lung Cancer in Mice Model

Zhenjie Xu, Lihuan Zhu, Shentao Wang

pp. 421–430 · DOI: 10.5530/ijper.20262240 · Published 2018

Background: Lung cancer, a malignancy resulting from the uncontrolled growth of cells in pulmonary tissues, remains to be a primary cause of cancer-associated deaths worldwide, requiring a thorough understanding of its c…

Indian Journal of Pharmaceutical Education and Research, Vol 60, Online First DOI: 10.5530/ijper.20260726 Copyright Information : Copyright Author (s) 2026 Distributed under Creative Commons CC-BY 4.0 Publishing Partner : Manuscript Technomedia. [www.mstechnomedia.com] A Validated HPTLC Method for Simultaneous Estimation of Berberine and Trigonelline in Polyherbal Mixture A Tool for Quality Control and Standardization

Sneha Basangouda Patil, Sunil Satyappa Jalalpure, Priya Prakash Shetti

pp. 431–441 · DOI: 10.5530/ijper.20260726 · Published 2026

Introduction: Berberis aristata and Trigonella foenumgrecum have been used in traditional medicine for various purposes due to their diverse therapeutic benefits such as anti-inflammatory, antidiabetic, antihypertensive …

Stability Indicating Method Development and Validation by Analytical Quality by Design Approach Using UV-Spectrophotometer for Alfuzosin Hydrochloride and Tadalafil in Bulk and Marketed Formulation

Shalaka G Gaonkar, Basavaraj Mrutyunjay Dinnimath

pp. 442–451 · DOI: 10.5530/ijper.20261965 · Published 2026

Introduction: The combination of Alfuzosin and Tadalafil is used to treat both erectile dysfunction and lower urinary tract symptoms. The purpose of this work is to develop and evaluate a UV-spectrophotometric method for…

Prevalence of Depression in the Diabetic Population and its Influence on Glycaemic Profile: A Prospective Interventional Study

Shaik Karimulla

pp. 452–459 · DOI: 10.5530/ijper.20261640 · Published 2018

Objectives: The study aims to determine the prevalence of depression in the diabetic population and its influence on glycaemic profile. Materials and Methods: A prospective interventional study was conducted at Narayana …