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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Investigatıon of the Protective Effect of Hydrogen Sulphide Donor Sodium Hydrosulphide and Sulfurized Apricot on Experimental Acute Kidney Injury Induced by Cisplatin in Rats

Nihan Celikoz1, Yakup Yilmaztekin1, Ozlem Cankaya1, Aslı Taslidere2, Rumeyza Hilal Datli3, Ayse Burcin Uyumlu1, Metin Fikret Genc4, Kadir Batcioglu1★★ Corresponding author

  1. 1Department of Biochemistry, Faculty of Pharmacy, Inonu University, Malatya, TURKEY.
  2. 2Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, TURKEY.
  3. 3Konya City Hospital, Basic Medical Sciences, In vitro Fertilization Center, Konya, TURKEY.
  4. 4Faculty of Medicine, Inonu University, Institute of Health Sciences, Public Health, Malatya, TURKEY.

CORRESPONDENCE

Kadir Batcioglu

Department of Biochemistry, Faculty of Pharmacy, Inonu University, Malatya, TURKEY.

kadir.batcioglu@inonu.edu.tr

Received: 02-05-2025; Revised: 21-06-2025; Accepted: 27-08-2025.

Volume 60, Issue 1 · pp. 410–420 · PUBLISHED 2018 · DOI: 10.5530/ijper.20261390

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ABSTRACT

Background: In the present study, we aimed to investigate the protective effect of Hydrogen sulfide (H2S) donor Sodium Hydrosulphide (NaHS) and Sulfurized Apricot (SA) on experimental acute kidney injury induced by cisplatin in rats. Materials and Methods: Four groups of Wistar albino rats were formed with 10 rats in each group: Control group, Cisplatin group, Cisplatin+SA group, and Cisplatin+NaHS group. The activities of Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx) and Cystathione gamma-lyase (CSE), and the levels of Malondialdehyde (MDA), Glutathione (GSH) and total GSH were measured. Creatinine, urea, Sodium (Na), Chlorine (Cl), Potassium (K), Calcium (Ca), Aspartate aminotransferase (AST), and Alanine Aminotransferase (ALT) were also measured. Results: CAT activity increased in the cisplatin+SA and cisplatin+NaHS groups. CSE activity increased in the cisplatin+NaHS group. MDA levels increased in the cisplatin and cisplatin+NaHS groups. This increase was also observed in SOD and GPx activities but was not statistically significant. Serum ALT, AST, creatinine, and urea levels were higher in the cisplatin group. ADP activity was lower in the cisplatin group. The histological findings support the biochemical results obtained in our study. Red/total GSH was higher in the cisplatin, cisplatin+SA, and cisplatin+NaHS groups. Conclusion: SA and NaHS would have beneficial effects in preventing cisplatin-induced kidney damage.

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    Celikoz, N., Yilmaztekin, Y., Cankaya, O., Taslidere, A., Datli, R. H., Uyumlu, A. B., Genc, M. F., & Batcioglu, K. (2018). Investigatıon of the Protective Effect of Hydrogen Sulphide Donor Sodium Hydrosulphide and Sulfurized Apricot on Experimental Acute Kidney Injury Induced by Cisplatin in Rats. Indian Journal of Pharmaceutical Education and Research, 60(1), 410–420. https://doi.org/10.5530/ijper.20261390