Volume 60, Issue 1S

· pp. s358–s361 · 41 articles

Volume: 60
Issue: 1S
Published
Pages: s358–s361
Articles: 41
Sections: 3
ISSN: Online - 0019-5464
Journal: IJPER

Research Article Original Article Commentary

In this issue

Research Article

Article
The Role of EPAC in the Pathogenesis of Cardiovascular Complications: A Review
Nandini Dubey, Vishal Kumar Vishwakarma, Aanchal Verma, Ahsas Goyal, Harlokesh Narayan Yadav
pp. s1–s10 · DOI: 10.5530/ijper.20260398 · Published
Cardiovascular disease is a primary cause of mortality and disability and it has long been a focus of clinical and scientific investigation. There is still much to learn about the intricate pathophysiology of cardiovascu…
Article
Global Comparison of Gene and Cell Therapy Regulations: A Cross-Regional Analysis of FDA, EMA, TGA, CSFDA, DCGI, PMDA, IFDA and MFDS
Seyed Heidar Mohammadi, Gholamhossein Sadeghian, Hoseein Shomali, Mohamadreza Abedi, Behrooz Jannat, Faham Khamesipour
pp. s18–s32 · DOI: 10.5530/ijper.20260001 · Published
Gene and cell therapies mark a transformative step forward in treating diseases such as cancer, genetic disorders and autoimmune conditions. However, regulatory pathways for these therapies differ worldwide, impacting ap…
Article
Review on Exploring the Combination Effect of Aldosterone along with Plasma Renin with Melatonin and Hydro-Cortisol in Diurnal Rhythm
Mainak Pal, Masud Sk, Saheli Mandal, Dipanjan Mandal
pp. s33–s41 · DOI: 10.5530/ijper.20260468 · Published
Aldosterone and plasma renin activity play a role in regulating our blood stress and fluid level while melatonin and cortisol help manage our sleep wake cycles as well as our reaction to stress. These hormones go through…
Article
Regulatory Pathway for Genotoxic Impurities in Europe, US, Canada, India, Australia and UK
Kavyashree Kadehalli Ramegowda, Sangita Mishra, Venkatesh Madhugiri Prakash
pp. s42–s51 · DOI: 10.5530/ijper.20260762 · Published
Genotoxic Impurities (GTIs) pose a significant risk to pharmaceutical safety due to their ability to damage DNA and cause cancer-related mutations. Regulatory agencies such as the EMA, USFDA, Heath Canada, CDSCO and TGA …
Article
Project-Based Learning with Virtual Laboratories to Promote Higher-Order Thinking Skills to Achieve Competency in Chemical Separation
Manihar Situmorang, Mita Mahrani, Hendra Simanjuntak, Jamalum Purba, Marudut Sinaga, Marham Sitorus, Ajat Sudrajat
pp. s52–s64 · DOI: 10.5530/ijper.20260625 · Published
Background:Higher-order thinking skills become life skills for pharmacists and scientists that are needed in solving scientific problems and can be obtained through implementing appropriate learning models. Objectives: T…
Article
Enteric Coated Sustained Release Mucoadhesive Tablet of Metronidazole for Targeted Colon Delivery: A Formulation and Evaluation Study
Latika Bisht, Mansi Butola, Assem Babbar, Abhijeet Ojha, Tarun Parashar, Yogita Ale, Shilpa Rana, Vikash Jakhmola
pp. s65–s73 · DOI: 10.5530/ijper.20260414 · Published
Background: Colon-specific Drug Delivery Systems (CDDS) are useful for treating many localized conditions such as ulcerative colitis, Crohn’s disease, irritable bowel syndrome, chronic pancreatitis and colonic cancer. In…
Article
Development and Optimization of Eletriptan Hydrobromide Sublingual Tablet Using Central Composite Design and in vitro Characterization
Vaishali Raghuwanshi, Akanksha Dwivedi, Gajanan Darwhekar
pp. S74–S82 · DOI: 10.5530/ijper.20265387 · Published
Background: In the current research, the sublingual tablets were formulated by utilizing a solid dispersion by physical mixture technique using sodium starch glycolate works as a super disintegrant and cyclodextrin works…
Article
Formulation and Characterization of Clotrimazole Loaded Polymeric Nanoparticles Fabricated by Single Emulsion Evaporation Technique
Valikala Viswanath, Palla Venkata Murali Krishna, Vankam Lokeswara Babu, Tanuja Anajigere Mruthunjaya Lakkamma
pp. s83–s92 · DOI: 10.5530/ijper.20260603 · Published
Aim/background: Utilizing nanotechnology allows us to shrink machinery down to the atomic level, leading to groundbreaking progress in technical innovation. Our most recent efforts concentrated on developing polymeric na…
Article
Formulation, Characterization and Optimization of Transdermal Patches of Venlafaxine Hydrochloride Using 32 Full Factorial Approach
Ashutosh Bansal, Navneet Garud, Ramakant Joshi, Rajendra Chauhan, Hemant Mourya, Pawan Kushwah, Trapti Sahu
pp. s93–s100 · DOI: 10.5530/ijper.20265993 · Published
Introduction: The primary objective of the present investigation was to develop transdermal patches that would extend the half-life of Venlafaxine Hydrochloride and boost its bioavailability. Transdermal patches were mad…
Article
Formulation, Optimization and Evaluation of Barbaloin Loaded Phytosomal Gel for the Treatment of Psoriasis
Mukesh Vinod Kapse, Jameel Ahmed Sayed Gous Mulla
pp. s101–s111 · DOI: 10.5530/ijper.20260663 · Published
Background:Phytosomes are one such unique approach gaining popularity due to their capabilities in controlled release and targeted delivery. These advanced herbal formulations significantly enhance the bioavailability of…
Article
Fabrication and Characterisation of Azithromycin-Loaded Ethosomes as an Advanced Vesicular Carriers for Acne Therapy
Abishek Kumar Anant Patil, Prashant Shivanand Halagali, Rahul Ramesh Koli, Nisha Shirkoli, Veerkumar Prakash Japti, Kishori Prasanna Sutar
pp. s112–s123 · DOI: 10.5530/ijper.20260668 · Published
Aim: This study is aimed to design and evaluate azithromycin-loaded ethosomes as an innovative approach to address the limitations of conventional azithromycin topical dosage forms in the treatment of acne. Materials and…
Article
Development and Evaluation of Levofloxacin-Based In situ Floating Gel for Enhanced Gastric Retention
Aniket Anand Nale, Priyanka Abaso Thorat, Jameel Ahmed Sayed Gous Mulla
pp. s124–s135 · DOI: 10.5530/ijper.20260759 · Published
Background: This work focuses on the development and testing of a floating in situ gel system based on sodium alginate that delivers levofloxacin to treat stomach Helicobacter pylori infections. Materials and Methods: As…
Article
Leveraging Factorial Design for Enhancing Formulation of Ketorolac Tromethamine Fast-Disintegrating Tablets
Suryaprakash Reddy Chappidi, Deepa Mopuri
pp. s136–s144 · DOI: 10.5530/ijper.20260504 · Published
Aim: Fast disintegrating tablets of Ketorolac tromethamine were prepared by formulating it with various super disintegrants with view to reduce disintegration time of tablets and to increase dissolution properties. Mater…
Article
Development and Statistical Optimization of Aquasomes Containing Ketoprofen: 2-Factor 2-Level Factorial Design Approach
Megha Pudukulam Mana, Sivakumar Ramakrishnan
pp. s145–s150 · DOI: 10.5530/ijper.20260916 · Published
Purpose: The purpose of the research work was to develop Aquasomes containing Ketoprofen (AQ-KP) for enhanced stability of the drug with improved therapeutic effect. Materials and Methods: The aquasomes are formulated by…
Article
Pharmacokinetics Studies of Lurasidone Hydrochloride in Nano Structured Lipid Carrier Formulation for Nasal to Brain Delivery
Tanvi Kadam, Surendra Agrawal, Saritha Shetty
pp. s159–s167 · DOI: 10.5530/ijper.20260543 · Published
Aim:Lurasidone Hydrochloride (LH) is a benzothiazole derivative used as an antipsychotic drug for the treatment of schizophrenia. Oral administration of Lurasidone hydrochloride, however, results in low bioavailability a…
Article
Pulmonary Drug Delivery of Budesonide in the Form of Inhalable Microspheres
Neha Padiyar, Vikash Jakhmola
pp. s168–s175 · DOI: 10.5530/ijper.20261573 · Published
Objectives: Chronic Obstructive Pulmonary Disease (COPD) is a major healthcare issue that is rising and expected to increase in day-to-day life. Our research work focused on developing Dry Powder Inhaler (DPI) microspher…
Article
Evaluation of Anti-Tumour Efficacy of Liposomes Loaded with Rubitecan as Potential Antitumor Drug Delivery System
Farsiya Fatima, Munuswamy Komala
pp. s176–s183 · DOI: 10.5530/ijper.20264331 · Published
Aim:The present research objective was to characterize the prepared liposomes for in vitro cytotoxicity assay, cellular uptake studies of liposomes, competitive binding assay and hemolytic test. Materials and Methods:The…
Article
Investigating the α-Amylase Inhibitory Effects of Adansonia digitata L.: A Comprehensive in vitro and Computational Study
Shirish Sidgonda Patil, Suresh Ganpati Killedar
pp. s184–s193 · DOI: 10.5530/ijper.20261273 · Published
Background: The study explores Adansonia digitata L.s potential in diabetes management through phytochemical and protein analyses. Materials and Methods:Eight identified phytoconstituents, comprising alkaloids, terpenes …
Article
Protective Effects of Petroselinum crispum Ethanolic Extract Against D Galactose and Aluminum Chloride Induced Alzheimers Disease in Rats A Behavioral and Biochemical Approach
P Aswin, G Sivakumar
pp. s194–s204 · DOI: 10.5530/ijper.20263885 · Published
Background: Alzheimer’s disease is one of the progressive neurodegenerative disorders affecting the elderly population without a clear etiology, accounting for more than 80% of dementia worldwide. We found the D-Gal and …
Article
Probe Sonication-Based Green Synthesis AgNPs Using P. Guajava Leaves Extract and Anticancer Behavior MCF-7 Cell Lines
Abhishek Singh, Vikash Jakhmola, Naveen Chandra Joshi, Tarun Parashar
pp. s205–s211 · DOI: 10.5530/ijper.20261382 · Published
Purpose: The present work is devoted to the green and probe sonication-based fabrication of AgNPs using the leaves extract of P. guajava.Materials and Methods: Various analytical techniques have been used to characterize…
Article
Investigation of Anti-Cancer Potency of Sarsasapogenin: In vitro and In silico Insights against MDR Cell Line-KB-Chr-8-5
Fatemah Abdulaziz Alhakami, Wedad Mawkili, Faten F Bin Dayel, Abdullah Mawkili, Amirah Albaqami, Norah T.S Albogamy, Shilpa Perumal Narasimhamoorthi
pp. s212–s222 · DOI: 10.5530/ijper.20262682 · Published
Objectives:Cancer recurrence is a major global concern, contributing to the rising mortality rates in the most common types of cancer. To overcome these incidents, highly qualified herbal medicines are more targetable, t…
Article
Potential of Ethanol Extract of Suruhan Leaves (Peperomia pellucida L. Kunth) in Regulating TNF-α, VEGF and Histopathological Changes in Wounds in Mice with Diabetic Ulcers
Enggrek Pelita Hakim, Jekson Martiar Siahaan, Endy Juli Anto
pp. s229–s237 · DOI: 10.5530/ijper.20260761 · Published
Background:Diabetes Mellitus (DM) is a chronic and progressive metabolic disorder characterized by an increase in blood glucose levels (hyperglycemia) because the pancreas does not produce enough insulin or the body is u…
Article
Preparation and Pharmacological Evaluation of Potential Hypolipidemic Activity of Yemeni Activated Charcoal
Ahmed Mohammed Al-Ghani, Mohammed Alkhawlani, Abdulrahaman Humaid, Anes Thabet, Hassan Ibrahim
pp. s233–s228 · DOI: 10.5530/ijper.20266915 · Published
Background: Activated charcoal is a common form of carbon that is used to filter pollutants from water and air, among numerous other uses. It is a very useful adsorbent, due to their high surface area, pore structure, an…
Article
Neuroprotective Effect of the Isolated Fraction from Biophytum sensitivum on Glutamate-Induced Neurotoxicity in HT22 Neuronal Cells
Prasanthi Guntur, Gurugubelli Sowjanya, Veera Mani Deepika, Matta Sarika, Nagaraju Bandaru, Makarand Suresh Gambhire, Alla Narayana Rao, Nuziveeti Lakshmi Durga Bhavani
pp. s238–s244 · DOI: 10.5530/ijper.20266535 · Published
Background:The present research paper elucidates to isolate specific fractions from Biophytum sensitivum and assess its ability to protect HT22 neuronal cells (immortalized mouse hippocampal neuronal cells) from glutamat…
Article
Influence of ABCB1 Polymorphisms on Outcomes of Breast Cancer
Sambasivam Gopinath, Deepak Gopal Shewade, Biswajit Dubashi, Ananthakrishnan Ramesh, Saranya Puniyakotti, Nithya Puniyakotti
pp. s245–s251 · DOI: 10.5530/ijper.20261224 · Published
Background: The importance of genotyping ABCB1 polymorphism genes in predicting the outcome of breast cancer patients receiving anthracycline and taxane-based regimens was reported. However, interethnic variations play a…
Article
To Evaluate the Safety and Efficacy of Autologous Nonspecific Activated T-Cells Therapy For 7,12-Dimethylbenz[A]Anthracene (DMBA) Induced Breast Cancer in Female Rats-A Supportive Care
Saroj Kumar Sah, Deepak Kumar Jha, Mehdi Fathima
pp. s252–s260 · DOI: 10.5530/ijper.20261253 · Published
Background and objectives:Breast cancer persist a core cause of mortality in women, and current treatments like Tamoxifen often fail to address immune suppression within the tumor microenvironment. Autologous nonspecific…
Article
Dexamethasone-Induced Osteoblast Toxicity: Bioenergetics Dysfunction and Oxidative Stress Unmask Apoptotic Pathways
Ekramy M Elmorsy, Ayat B Al-Ghafari, Huda A Al Doghaither, Majed G Alrowaili, Zenat A Khired, Manal S Fawzy, Shaimaa A Shehata
pp. s261–s273 · DOI: 10.5530/ijper.20261072 · Published
Aim: Dexamethasone (DEX) is a glucocorticoid commonly used to treat autoimmune and non-infectious inflammatory diseases; however, its role in inducing osteoporosis is poorly understood. Materials and Methods: This study …
Article
Insulin Secretory Dysfunction as the Underlying Mechanism of Diabetogenesis in Neonatal Streptozotocin-Induced Type 2 Diabetes Model Rats
Ramendu Parial, Manisha Das, Masfida Akhter, JMA Hannan, Dwaipayan Sikdar, Liaquat Ali
pp. s274–s279 · DOI: 10.5530/ijper.20266401 · Published
Background: Neonatal Streptozotocin (n-STZ) rats are widely used as models for type 2 diabetes mellitus, but the basic defects of diabetes (insulin secretion and resistance) have not yet been adequately characterized in …
Article
Synthesis, Purification and Characterization of Some Impurities of Propranolol
Pradnya Sangram Waghmare, Amit Suryakant Tapkir, Pavin Digambar Chaudhari, Ashok Bhau Pathak, Sandip Murlidhar Bhagat, Sneha Nandkumar Rashinkar, Anuradha Ghanshyam More, Padmaja Santosh Kore
pp. s280–s286 · DOI: 10.5530/ijper.20265308 · Published
Introduction:During the process of drug development, control of impurities and it should keep within the prescribed limit is very important to get high-qualified drugs. Several studies have been dedicated to synthesizing…
Article
Azilsartan Medoxomil and Cilnidipine Spectrophotometric Determination in Bulk and Formulation: A Validated Dual Wavelength Method
Siddalinga Swamy M. S, Prakash S Sarsambi, Lavanya Patil M P, Shwetha M, Santhosh B M
pp. s287–s292 · DOI: 10.5530/ijper.20263605 · Published
Introduction:If there is a rise in blood pressure then that condition is called hypertension. Azilsartan medoxomil and Cilnidipine is a new combined dosage form used in the treatment of Stage II Hypertension. Objectives:…
Article
Machine Learning Assisted Simultaneous Estimation of Drugs in Multicomponent Formulations by Spectrophotometry
Mariya Thomas, Kavitha M Parameswaran, Anjaly P Johny, Kannan Kamarajan, Krishnakumar Kunnambath
pp. s293–s303 · DOI: 10.5530/ijper.20265275 · Published
Analysis of multi-drug formulations by spectrophotometric method is a challenging task due to mutual interference. Mathematical models reported for such analysis are applicable only where there are well separated absorpt…
Article
RP-HPLC Estimation of Azelnidipine and Chlorthalidone in Bulk and Combined Dosage Forms
Anamika Singh, Tamanna Narsinghani
pp. s304–s311 · DOI: 10.5530/ijper.20265371 · Published
Objectives: A simple, sensitive, robust, precise and efficient RP-HPLC approach for the simultaneous determination of Azelnidipine and Chlorthalidone in combination. Materials and Methods: As per ICH Q2 (R1) guidelines, …
Article
Development and Validation of Stability Indicating Liquid Chromatographic Method for Simultaneous Estimation of Silodosin and Dutasteride in API and Combined Dosage Form
Sapna Rathod, Ayushi Shah, Nisarg Patel, Maulik Mehta, Bhupendra Prajapati
pp. s312–s319 · DOI: 10.5530/ijper.20265613 · Published
Background:The proposed work was done with a view to develop a RP-HPLC approach for the concurrent quantification of Dutasteride and Silodosin in API and capsule formulation and validate it. Materials and Methods:A C18 T…
Article
Degradation Kinetics and Characterization of Canagliflozin Under Solution Stress by LC and LC-MS/MS Method
Krishna Radheshyam Gupta, Swapnil Anilrao Thakre, Monali Balkrushna Yerne, Milind Janrao Umekar
pp. s320–s327 · DOI: 10.5530/ijper.20266836 · Published
Objectives: Using the RP-HPLC method, this work investigates the degradation behavior of canagliflozin and its commercial formulation under ICH-recommended stress conditions. It also validates the suggested method and an…
Article
Spectrophotometric Estimation of Olmesartan Medoxomil and Metoprolol Succinate in Tablet Dosage Form by Zero Order Derivative and Area Under the Curve Method
Faiz Ahmed, Rina Das, Dinesh Kumar Mehta, Samir Patel, Archita Patel
pp. s328–s335 · DOI: 10.5530/ijper.20260440 · Published
Background: Olmesartan Medoxomil (OLM) and Metoprolol succinate (MET) formulations treat hypertension. The primary goal was to develop and evaluate a UV-spectrophotometric method for simultaneous estimation of OLM and ME…
Article
Development of a New Validated RP-HPLC Method for Simultaneous Estimation and Stability Study of Tegafur, Gimeracil and Oteracil in Combined Dosage Form
Panchumarthy Ravisankar, Sathish Kumar Konidala, Kamma Harsha Sri, Chaitanya Sucharitha Kolakaluri, Munnangi Mukkanti Eswarudu, Venkata Prasad Rao Chinni, Srinivasa Babu Puttagunta
pp. s336–s343 · DOI: 10.5530/ijper.20265079 · Published
Aim: This study developed a validated and stability-analyzing Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) method for simultaneous determination of selected drugs Materials and Methods: Separation, quan…
Article
Reliability of Virtual Objective Structured Clinical Examination in Pharmacy Practice Experience Education Using Generalizability Theory
Palanisamy Amirthalingam
pp. s344–s349 · DOI: 10.5530/ijper.2021159 · Published
Background and Objectives: The virtual Objective Structured Clinical Examination (OSCE) was established using the MyDispense database in various pharmacy schools worldwide. However, rigorous reliability estimation is lac…
Article
Mechanism of Reactive Oxygen Species in the Photo-Cytotoxicity and Photo-Apoptotic Effects of Ciproquin on L929 Cells
Daoud Ali, Saud Alarifi, Bader Almutairi, Mohammed Hasan Almarzoug, Saad Alakhtani
pp. s350–s357 · DOI: 10.5530/ijper.20262410 · Published
Background:Photo-unstable drugs cause undesirable clinical side effects by acting as photo-toxin in the skin and other tissue under the exposure of sunshine. Ciproquin is an antibiotic that is used to treat bacterial inf…

Original Article

Article
Co-Delivery of Luminescent C-dots and Clonidine Hydrochloride Loaded Nanocarriers for the Effective Management of Glaucoma
Nivedita Shukla, Rajkeshwar Prasad, Nidhi Bhatt
pp. s151–s158 · DOI: 10.5530/ijper.20265229 · Published 2026
Aim/Background: Glaucoma is an eye illness associated with Intraocular Pressure (IOP) that, if untreated, can lead to significant vision impairments and potentially complete blindness. Research indicates that eye infecti…
Article
Unveiling Novel Insights in Chronic Myeloid Leukemia Cell Lines K562 through in vitro and in silico Approach Targeting of Apoptosis and Oxidative Stress Pathways
Hassan H Almasoudi
pp. s358–s370 · DOI: 10.5530/ijper.20263903 · Published
Introduction:Troxerutin (TR), bioflavanoid derived from rutin posess several biological activity like antioxidant, antinflammatory, antidiabetic and antitumor activity and found to be alternative candidate for cancer the…

Commentary

Article
AI/ML-Based Medical Devices
Narendra Kumar Jain
pp. s358–s361 · DOI: 10.5530/ijper.20261314 · Published
In order to manage health emergencies, develop universal health care, and encourage healthier communities, access to relevant, reasonably priced, and high-quality health products (including medical devices) is crucial. W…