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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Probe Sonication-Based Green Synthesis AgNPs Using P. Guajava Leaves Extract and Anticancer Behavior MCF-7 Cell Lines

Abhishek Singh1, Vikash Jakhmola2★, Naveen Chandra Joshi3, Tarun Parashar4★ Corresponding author

  1. 1Department of Pharmaceutics, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, INDIA.
  2. 2Department of Pharmaceutical Chemistry, Uttaranchal Institutes of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, INDIA.
  3. 3Department of Chemistry, Graphic Era (Deemed to be University), Dehradun, Uttarakhand, INDIA.
  4. 4Department of Pharmaceutics, School of Pharmacy & Research, Dev Bhoomi Uttarakhand University, Dehradun, Uttarakhand, INDIA.

CORRESPONDENCE

Vikash Jakhmola

Department of Pharmaceutical Chemistry, Uttaranchal Institutes of Pharmaceutical Sciences, Uttaranchal University, Dehradun, Uttarakhand, INDIA.

jakhmola.1979@gmail.com

Received: 02-05-2025; Revised: 30-06-2025; Accepted: 18-08-2025.

Volume 60, Issue 1S · pp. s205–s211 · PUBLISHED · DOI: 10.5530/ijper.20261382

View on IJPER original site ↗

ABSTRACT

Purpose: The present work is devoted to the green and probe sonication-based fabrication of AgNPs using the leaves extract of P. guajava.Materials and Methods: Various analytical techniques have been used to characterize the synthesized AgNPs, which examine significant chemical and physical characteristics of AgNPs.Results:The green synthesized AgNPs were used against a breast cancer cell line (MCF-7). The FTIR study indicates the presence of O-H, C=O, C=C, and C-Ag bonds on the surface of AgNPs. The XRD peaks of AgNPs were found to be 27.8º, 32.2º, 38.1º, 44.4º, 45.6º, 57.1º, 64.5º, and 77.9º respectively. The MTT assay of AgNPs showed increased cytotoxicity against MCF-7 cell lines with the half maximal inhibitory concentration of 24.44 µg/ mL. Conclusion:The findings suggest that AgNPs synthesized from P. guajava leaves exhibit significant anticancer activity against MCF-7 cell lines, highlighting their potential for therapeutic applications.

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    Singh, A., Jakhmola, V., Joshi, N. C., & Parashar, T. (). Probe Sonication-Based Green Synthesis AgNPs Using P. Guajava Leaves Extract and Anticancer Behavior MCF-7 Cell Lines. Indian Journal of Pharmaceutical Education and Research, 60(1S), s205–s211. https://doi.org/10.5530/ijper.20261382