Volume 59, Issue 4

2025 · pp. 1238–1644 · 39 articles

Volume: 59
Issue: 4
Published: 2025
Pages: 1238–1644
Articles: 39
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Review Article Original Article

In this issue

Review Article

Review
The Construction and Application of Process Evaluation in the Grade Evaluation of Pharmacology Experiment
Hua Li, Lin Liu, Mao Li, Yuhong Sun, Minghua Liu
pp. 1238–1244 · DOI: 10.5530/ijper.20257182 · Published 2025
Pharmacology laboratory teaching includes basic animal handling, basic experiments, integrated experiments, designed experiments and scenario-based discussions between doctors and patients. The problems in the evaluation…
Review
Navigating USFDA Inspectional Observations: An Analysis of Trends and Compliance from Fiscal Years 2019 To 2022
Antony Sebastian Johnson, Balamuralidhara Veeranna, Saba Maanvizhi
pp. 1245–1253 · DOI: 10.5530/ijper.20250523 · Published 2025
The Food and Drug Administration (FDA) known for its rigorous regulatory oversight, conducts routine inspections in the pharmaceutical industry, utilizing Form 483 to highlight observed non-compliances. Inadvertent breac…
Review
Enhancing Lyophilization Efficiency: A Review of Processes, Parameters and Product Preservation Strategies
Dhakane Sumeet, Jain Rahul, Joshi Neeta
pp. 1254–1261 · DOI: 10.5530/ijper.20251071 · Published 2025
Lyophilization, often known as freeze-drying, is a critical process widely utilized in pharmaceuticals and biotechnology to preserve sensitive materials. This paper examines key parameters influencing lyophilization qual…
Review
Nose-to-Brain Drug Delivery: An Update on Clinical Challenges and Progress
Purushottam Gangane, Nikita Raulkar, Nikita Wagh, Vijaya Rabade, Harigopal Sawarkar
pp. 1262–1271 · DOI: 10.5530/ijper.20253959 · Published 2025
In 1987 James Parkinson first describes Parkinson's Disease (PD) as a neurological syndrome. Over ten million people worldwide suffer with PD. The exact quantity of people suffered with PD is difficult to calculate becau…

Original Article

Article
Students' Perception of the “Two-Stage” Collaborative Examination Based on the Focus Group Interview Method
Li Ming Wang, Yan Chun Wang, Shan Shan Li, Ying Jin
pp. 1272–1276 · DOI: 10.5530/ijper.20255653 · Published 2025
Background: Two-stage collaborative exams have been proven to improve students’ performance and enhance students’ learning efficiency. However, there is no quality study on students' perception of two-stage exams through…
Article
Investigate of the Relationship between Thinking Styles and Classroom Management of the Teachers of Vocational Colleges
Weiguo Hu, Zi Ye, Chou Chen, Wei Chen, Chan Li, Haijun Zhou, Ruiyang Chen
pp. 1277–1284 · DOI: 10.5530/ijper.20253776 · Published 2025
Aim/Background: This study investigated the relationship between thinking styles and classroom management among teachers at X (anonymous) Vocational College of China during the academic year 2021-2022. Materials and Meth…
Article
Screening and Optimization of Various Formulation and Processing Parameters for the Development of Aquasomes
Khushboo Katharotiya, Dhaval Katharotiya, Lalit Lata Jha
pp. 1285–1292 · DOI: 10.5530/ijper.20250371 · Published 2025
Objectives: The research aims to enhance understanding of aquasome preparation, offering insights into optimizing formulations for potential applications in drug delivery systems. Materials and Methods: Aquasomes compose…
Article
Co-Delivery of Sphingosomal Formulation Containing BCL2 siRNA Doxorubicin for the Treatment of Lung Cancer
Prashant Nayak, Rompicherla Narayana Charyulu
pp. 1293–1304 · DOI: 10.5530/ijper.20257236 · Published 2025
Background: Lung cancer continues to pose a major challenge to global health, with limited therapeutic options and high mortality rates. One factor that contributes to this is the overexpression of BCL2, an anti-apoptoti…
Article
Formulation, Optimization and Evaluation of Naringenin Loaded Cubosomes for Effective Management of Alzheimer's Disease
Yashowardhan Raut, Kishori Prasanna Sutar, Shivaraj Hooli, Gautam Naik, Vinayak Udagatti
pp. 1305–1311 · DOI: 10.5530/ijper.20251264 · Published 2025
Objectives: The goal of this work was to formulate a stable naringenin-loaded cubosomal in situ gel to improve naringenin absorption into the brain by direct nose-to-brain transfer. Materials and Methods: This investigat…
Article
Formulation and Evaluation of Propolis Loaded Nanosponges Based Topical Anti-Inflammatory Gel
Mukesh P. Ratnaparkhi, Swati Dattatray Kshirsagar
pp. 1312–1322 · DOI: 10.5530/ijper.20251073 · Published 2025
Objectives: To develop and evaluate a Propolis-Loaded Nanosponge (PLN)-based topical gel with potential anti-inflammatory, antifungal and antibacterial activities. Materials and Methods: PLNs were prepared using the emul…
Article
Formulation Development and Evaluation of Iloperidone Loaded Nanosuspension for Solubility Enhancement
Shivraj Popat Jadhav, Prashant Kumar Dhakad, Tapasvi Gupta, Ritu Gilhotra
pp. 1323–1333 · DOI: 10.5530/ijper.20250282 · Published 2025
Introduction: Iloperidone is categorised as an antipsychotic drug and is used to treat schizophrenia. Iloperidone belongs to the Biopharmaceutics Classification System class II due to its low water solubility. Objectives…
Article
Antioxidant Assessment of Albizia lebbeck SLNs
S K Kavitha, Ali Mohammad, Bharathi D R, Yogesh H S
pp. 1334–1346 · DOI: 10.5530/ijper.20250803 · Published 2025
Aim: Nanotechnology is pivotal in the pharmaceutical industry, significantly augmenting drug properties and formulations. It enhances drug stability and controlled release, providing precise control over drug delivery sy…
Article
Repurposing Efavirenz for Anticancer Therapy with Curcumin Combination in Solid Lipid Nanoparticle Formulation
Mani Uppada, Srinivasa Rao Yarraguntla, Sai Sri Vastav Mylavarapu, Persis Joni Kappala, Satyalakshmi Siragam
pp. 1347–1356 · DOI: 10.5530/ijper.20257306 · Published 2025
Background: The aim of this study was to explore the potential of repurposing the anti-HIV drug Efavirenz (EFZ) in combination with Curcumin (CUR) for cancer therapy. EFZ is an antiviral drug and selective anti-HIV drug …
Article
Development and Optimization of Novel Microwave-Assisted Extraction for Rich-Flavonoids and Polyphenols from Dioscorea bulbifera Leaves by Response Surface Methodology
Soma Uday Kumar Reddy, Divya Jyothi, Krishna Kana Veetil, Shreya Shreya, Rokeya Sultana, Sneh Priya
pp. 1357–1365 · DOI: 10.5530/ijper.20250520 · Published 2025
Objectives: Microwave-Assisted Extraction (MAE) has emerged as a promising technique for the extraction of bioactive compounds from plant materials due to its efficiency and reduced processing time. In the present study,…
Article
Anti-inflammatory and Anti-allergic Effects of Salvigenin in an Ovalbumin-Induced Allergic Rhinitis in Mice
Nan Gong, Huimin Chang, Mengchao He, Xiaohong Zhang, Wenjing Li
pp. 1366–1374 · DOI: 10.5530/ijper.20251122 · Published 2025
Background: Allergic Rhinitis (AR) is a prevalent inflammatory disorder of the nasal mucosa, often triggered by an IgE-mediated immune reaction to allergens. The underlying cause of AR can be attributed to the genetic pr…
Article
Herniarin Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Regulating Oxidative Stress, Inflammation and Apoptosis Mechanisms
Li Jiang, Tao Zhang, Fangtao Yan, Jian Shen, Abdullah A. Alarfaj, Abdurahman Hajinur Hirad
pp. 1375–1384 · DOI: 10.5530/ijper.20251124 · Published 2025
Background: Acute Lung Injury (ALI) is a severe, serious condition characterized by the development of pulmonary edema, hypoxemia and respiratory distress. Objectives: The current work was intended to disclosing the bene…
Article
Evaluating Myricetin as a CDK2 Inhibitor in Lung Cancer: In silico and in vitro Assessment of a Flavonoid-Based Small Molecule
Abdulaziz Asiri
pp. 1385–1394 · DOI: 10.5530/ijper.20251924 · Published 2025
Background: Inhibiting Cyclin-Dependent Kinase 2 (CDK2) holds significant therapeutic potential for lung cancer by targeting a critical regulator of the cell cycle. CDK2 inhibition halts cancer cell proliferation, induce…
Article
Pennogenin Exerts Anti-inflammatory and Anti-nociceptive Effects in Several Models of Inflammation and Nociception in Mice
Yan Tao, Nan Cai, Juxia Zhang, Yaoping Zhao, Yan Zhou, Pengfei Liu
pp. 1395–1407 · DOI: 10.5530/ijper.20251146 · Published 2025
Background: The nociceptive pain is a fundamental sensory response that works as a crucial protective mechanism for the human body. Chronic pain constitutes a substantial public health issue, impacting millions of indivi…
Article
Modulation of Tuberculosis Pathway by Phaseolus vulgaris: An in silico Approach
Pradeep Kumar Mavinatop Ramanagouda, Santosh Basavaraj Patil, Sangameshwar Girimallappa Halkavatagi, Pankaj Kumar, Gupta Dheeraj Rajesh, Manisha Kuvalekar
pp. 1408–1418 · DOI: 10.5530/ijper.20255884 · Published 2025
Aim/Background: Traditionally, Phaseolus vulgaris is used to treat common diseases. However, the affinity of its phytocompounds with proteins involved in the pathogenesis of Tuberculosis (TB) has not yet been illuminated…
Article
Ameliorative Wound Healing Potency of Koenimbine via Attenuation of Inflammatory Cytokines in Hyperglycemia-Induced Rodent Model
Jing Xu, Fei Wang, Minjuan Zhang, Maoyuan Chen, Ke Zhao, Yang Liu, Dong Li
pp. 1419–1428 · DOI: 10.5530/ijper.20251256 · Published 2025
Background: Managing wounds in diabetic patients requires specialized approaches due to their unique healing challenges. Diabetic wounds, particularly Diabetic Foot Ulcers (DFUs), often exhibit delayed healing, increased…
Article
Harnessing Saussurea lappa for Anti-leishmanial, Anti-toxoplasmic, and Anti-bacterial Activity: Molecular and Computational Insights
Manal Mohamed Elhassan Taha, Siddig Ibrahim Abdelwahab, Muruganantham Bharathi, Waleed S. Koko, Ibrahim S. Al Nasr, Tariq A. Khan, Mohamed Eltaib Elmobark, Zia ur Rehman, Sivakumar S. Moni, Syam Mohan, Bassem Oraibi, Hassan Ahmad Alfaifi, Dina Abdulrahman Ismail Albadawi, Ahmed Ali Jerah, Yasir Babiker, Saleh M Abdullah, Ibrahim Abdel Aziz Ibrahim, Abdullah Farasani
pp. 1429–1443 · DOI: 10.5530/ijper.20251782 · Published 2025
Objectives: Saussurea lappa Clark has shown preliminary promise in various biological contexts. This study investigates the antileishmanial, antitoxoplasmic, and antibacterial activities of methanolic extracts from S. la…
Article
Pharmacological Evaluation of Buchanania lanzan Bark Against Alcohol Induced Liver Cirrhosis in Rats
Namrata Soundatte, Namit Kudatarkar, Rajashekar Chavan
pp. 1444–1455 · DOI: 10.5530/ijper.20256322 · Published 2025
Aim: The study aimed to assess the potential of Buchanania lanzan bark extract in mitigating alcohol-induced liver cirrhosis effects. Objectives: Included evaluating antioxidant and anti-inflammatory properties, explorin…
Article
Liquiritin Ameliorates Streptozotocin-Induced Gestational Diabetes in Pregnant Rat Model by Inhibiting Inflammation and Oxidative Stress Responses
Jiejie Xing, Fang Wang, Junxiu Wei, Chenyuan Cao
pp. 1456–1465 · DOI: 10.5530/ijper.20251618 · Published 2025
Aim/Background: Gestational diabetes is a significant medical complication that can develop during pregnancy, characterized by impaired glucose tolerance. This condition poses risks to both the mother and the developing …
Article
Wogonoside Mitigates Inflammation and Cell Proliferation via Modulation of NF-κB Signalling Pathway in DMBA-Induced Mammary-Preclinical Model
Chenyang He, Yu Zhang, Yan Diao, Xingcong Ma, Guochao Mao, Xinyu Wei, Yang Zhao
pp. 1466–1473 · DOI: 10.5530/ijper.20256082 · Published 2025
Objectives: To hypothesis the effect of wogonoside against DMBA-induced Breast Cancer (BC) via TNF-α induced NF-κB signaling pathway a molecular appraoch. Materials and Methods: A 25 mg/kg Body Weight (BW), DMBA mixed do…
Article
Neutralizing Effects of Mimosa pigra Stem-Bark against Selected Snake Venom from Malaysian Habitat
Nor Safwan Nor Afendi, Noor Syahila Ahamad Saferi, Vishal Bhagwan Badgujar, Nur Fatin Afiqah Mohd Fazil, Farheen Sami, Sangita Badgujar, Hameeth Shah, Arun Kumar, Shahnaz Majeed, Mohammed Tahir Ansari
pp. 1474–1482 · DOI: 10.5530/ijper.20257015 · Published 2025
Introduction: Mimosa pigra L. (M. pigra) regarded as significant undesirable weed in India, Africa, Australia, South-East Asia and some Pacific islands. Preliminary evidence of the use of the plants by rural community fo…
Article
In vitro and in silico Analysis Protosappanin B Exerts Anti-Tumor Activity on Breast Cancer Cells via Activating Pro-Apoptotic Caspase Enzymes
Xia Zhang, Shuangnian Deng
pp. 1483–1492 · DOI: 10.5530/ijper.20251723 · Published 2025
Background: Breast cancer is the most common cancer and the second leading cause of cancer-associated mortality in women globally. Breast cancer can metastasize or recur because of drug resistance and toxicity. Objective…
Article
Exploring Factors Affecting the Quantitative Analysis of Vitexin, Imperatorin and Gallic Acid in Tri-Kaysornmas Formulation
Suphatson Limsakul, Wissuta Roopngam, Yanisa Voeisarn, Thanaporn Pongmanachai, Yutthana Chotritthirong, Orawan Monthakantirat, Charinya Khamphukdee, Yaowared Chulikhit, Supawadee Daodee
pp. 1493–1500 · DOI: 10.5530/ijper.20250137 · Published 2025
Background: The Tri-kaysornmas formula is one of the Thai traditional formulas in Thailand. Many phytochemical active compounds are found in this formula such as vitexin, imperatorin and gallic acid. Objectives: The curr…
Article
Atorvastatin Ameliorates Neuroinflammatory Response in Experimental Intracerebral Hemorrhage Rats through the GSK-3β/β-Catenin Pathway
Jing Zhao, Mei Li, Lingling Zhang, Qi Zhang
pp. 1501–1510 · DOI: 10.5530/ijper.20250529 · Published 2025
Objectives: This study aimed to elucidate influence of Atorvastatin (ATV) on the neuroinflammatory response in experimental Intracerebral Hemorrhage (ICH) through the GSK-3β/β-catenin Signaling Pathway (SPW). Materials a…
Article
Modulatory Effects of Dietary Saturated Versus Omega-3 Fatty Acids on Cognitive Impairment, Depressive-Like Behavior, HPA Axis Dysregulation and Systemic Inflammation in Monosodium Glutamate-Treated Young Male Rats
Hebatallah Husseini Atteia, Amal F. Gharib, Mervat El-Sayed Askar, Manar Hamed Arafa, Gehan A. Ahmed, Amr Tawfik Sakr
pp. 1511–1521 · DOI: 10.5530/ijper.20251190 · Published 2025
Background and Objectives: Children consume fast food rich in saturated fats and flavor enhancers like Monosodium Glutamate (MSG). These agents might alter Hypothalamic-Pituitary- Adrenal (HPA) axis activity, inducing be…
Article
In silico and in vivo Evaluation of Antitumor Drugs against P. falciparum 3D7 Inhibit the Parasite Growth
Mohammad Aatif, Mohd Farhan, Ghazala Muteeb
pp. 1522–1533 · DOI: 10.5530/ijper.20251797 · Published 2025
Background: Plasmodium falciparum (P. falciparum) is the most lethal parasite that affectsmalaria in humans. The drugs such as Etoposide, Novobiocin, Netropsin, Nogalamycin and Daunorubicin may be useful in treating such…
Article
Silencing of S100A16 in Cervical Cancer Cells Inhibits Cancer Cell Growth by Inducing Autophagy via PI3K/AKT/ mTOR Signaling Pathway
Haibin Zhang, Wenhu Xing, Yufeng Li, Xianyun Xu
pp. 1534–1545 · DOI: 10.5530/ijper.20251170 · Published 2025
Objectives: Cervical Cancer (CC) ranks among the top 3 leading malignancies that affect the female reproductive system. This research focused on examining the impact of S100A16 silencing in HeLa and CaSki cells, alongsid…
Article
Afzelin Prevents against Lipopolysaccharide-Induced Acute Lung Injury and Sepsis via Inhibiting the Inflammatory Mediators
Honghui Zhao
pp. 1546–1552 · DOI: 10.5530/ijper.20251529 · Published 2025
Background: One of the main causes of death in critical care units and a serious consequence of sepsis is Acute Lung Injury (ALI). Studies have shown that afzelin reduces inflammation and oxidative damage. However, the p…
Article
Herniarin Mitigates High-Fat Diet-Induced Atherosclerosis in Rats via Regulation of Hyperlipidemia, Endothelial Dysfunction, Inflammation and Oxidative Stress
Jingyue Lai, Zongyu Li, Ying Zhang, Hao Guan, Jiancang Ma
pp. 1553–1564 · DOI: 10.5530/ijper.20251165 · Published 2025
Background: Atherosclerosis is a complex and multifactorial disease characterized by the buildup of plaque within the blood vessels, which can result in severe cardiovascular problems. Objectives: The present study attem…
Article
Therapeutic Potential of Lacidipine against 3- Nitropropionic Acid Induced Huntington's Disease: Based on Molecular Docking, Anti-Inflammatory and Neuroprotective Effects
Samiyah Alshehri, Muhammad Afzal, Sana Saeed Alqarni, Sattam Khulaif Alenezi, Khalid Saad Alharbi, Mohammad Jaffar Sadiq Mantargi, Imran Kazmi, Nadeem Sayyed, Faisal Imam
pp. 1565–1581 · DOI: 10.5530/ijper.20250579 · Published 2025
Background: Huntington's Disease (HD), a neurological ailment that leads to motor impairment, cognitive decline and psychiatric disorders, has limited treatment options. Hence, there is a pressing demand for new therapeu…
Article
In silico and In vitro Characterization of Potent CDK2 Inhibitors as Probable Cancer Therapeutics
Akram Ahmed Aloqbi
pp. 1582–1602 · DOI: 10.5530/ijper.20251532 · Published 2025
Background: Cyclin-Dependent Kinases (CDKs) are a family of serine/threonine protein kinases that play pivotal roles in the regulation of the cell cycle and various cellular processes. Among them, CDK2 is a crucial regul…
Article
Strengthening Finerenone Assessment: A Central Composite Design Viewpoint for Liquid Chromatographic Method Development
Paul Richard, Sarath Vothani, Srikrishna Theerthala, Kishore Boddu, Vasanth PM
pp. 1603–1612 · DOI: 10.5530/ijper.20251429 · Published 2025
Background: A RP-HPLC technique was created and proven for the measurement of Finerenone, a new medication currently being studied. The approach was improved to achieve excellent precision, accuracy, and sensitivity for …
Article
Analytical Method Development and Validation by RP-HPLC and UV Spectrophotometric for Estimation of Daprodustat in Bulk and Pharmaceutical Dosage Form
Pranita Prabhakar Patil, Sunita Sunil Gagare, Ashish Suresh Jain
pp. 1613–1622 · DOI: 10.5530/ijper.20250016 · Published 2025
Objectives: This research aimed to systematically boost the development and validation of newly devised, precise, reproducible and accurate UV and Reverse Phase High Performance Liquid Chromatography (RP-HPLC) methods fo…
Article
Identification and Comparison of Phytoconstituents of Essential Oil and Methanolic Extracts of Leaves and Rhizomes of Elettariopsis curtisii Grown in Malaysia via GCMS Analysis
Engku Nurul Najlaa, Sadia Sultan, Kamran Ashraf
pp. 1623–1632 · DOI: 10.5530/ijper.20251594 · Published 2025
Introduction: Elettariopsis curtisii (Zingiberaceae) is a high-value medicinal plant that has been used by the locals in Southeast Asia mainly to treat bloating and for postnatal care purposes. It contains many valuable …
Article
Impact of Pharmacist-Led Training on Breast Cancer Awareness and Knowledge: A Quasi-Experimental Pre-Post Study
Zekiye Yılmaz, Ceren Eliçetin
pp. 1633–1644 · DOI: 10.5530/ijper.20251409 · Published 2025
Background: Breast Cancer (BC) constitutes the primary cause of cancer-related mortality in females and BC burden is projected to rise to 3.19 million cases and 1.04 million deaths by 2040. Given the increasing prevalenc…