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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Influence of ABCB1 Polymorphisms on Outcomes of Breast Cancer

Sambasivam Gopinath1,2★, Deepak Gopal Shewade1, Biswajit Dubashi3, Ananthakrishnan Ramesh4, Saranya Puniyakotti2, Nithya Puniyakotti2★ Corresponding author

  1. 1Department of Pharmacology, JIPMER, Puducherry, INDIA.
  2. 2Department of Pharmacy Practice, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, INDIA.
  3. 3Department of Medical Oncology, JIPMER, Puducherry, INDIA.
  4. 4Department of Radiodiagnosis, JIPMER, Puducherry, INDIA.

CORRESPONDENCE

Sambasivam Gopinath

Department of Pharmacology, JIPMER, Puducherry, INDIA.

gopimbapharma@gmail.com

Received: 07-04-2025; Revised: 19-06-2025; Accepted: 22-08-2025.

Volume 60, Issue 1S · pp. s245–s251 · PUBLISHED · DOI: 10.5530/ijper.20261224

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ABSTRACT

Background: The importance of genotyping ABCB1 polymorphism genes in predicting the outcome of breast cancer patients receiving anthracycline and taxane-based regimens was reported. However, interethnic variations play a significant role in predicting the response to chemotherapy. Materials and Methods: This prospective study was carried out to assess the influence of ABCB1 genotypes on breast cancer response. Genotyping of ABCB1 was carried out by real-time PCR (7300 Applied Biosystems; Life Technologies Corporation, USA) using TaqMan SNP genotyping assays, Response assessments were evaluated as per RECIST criteria version. Results: A total of 170 locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy were recruited. The genotype frequencies of ABCB11236 homozygous wild-type variant CC, the heterozygous variant CT, and the mutant homozygous variant TT were 23.0%, 44.0%, and 33.0% respectively. The genotype frequencies of ABCB1 1236 homozygous wild-type variant CC, the heterozygous variant CT, and the mutant homozygous variant TT were 28.0%, 42.0%, and 30.0% respectively. Similarly, the ABCB1 2677 wild-type variant GG (18%), TT (26% AA (2% the heterozygous variant GA (7%), GT (45%), TA (2%), and the mutant homozygous variant were observed. Conclusion: Our study revealed that ABCB1 3435 C>T polymorphism was associated with response as patients with ABCB1 3435 mutant genotypes had better response. Patients having ABCB1 1236 mutant genotypes (CT & TT) had more risk for neutropenia and vomiting, suggesting the significance of ABCB1 genotypes in predicting response and toxicity in anthracycline-based regimens.

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    Gopinath, S., Shewade, D. G., Dubashi, B., Ramesh, A., Puniyakotti, S., & Puniyakotti, N. (). Influence of ABCB1 Polymorphisms on Outcomes of Breast Cancer. Indian Journal of Pharmaceutical Education and Research, 60(1S), s245–s251. https://doi.org/10.5530/ijper.20261224