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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Phytofabrication of Magnetite Nanoparticles from Piper betle (L.) var. Mysore and Evaluation of Anti-Breast Cancer Potentials

Ravikant Shekhar1, Harischandra Sripathy Prakash1, Nagaraja Geetha1★★ Corresponding author

  1. 1Department of Studies in Biotechnology, University of Mysore, Mysore, Karnataka, INDIA.

CORRESPONDENCE

Nagaraja Geetha

Department of Studies in Biotechnology, University of Mysore, Mysore, Karnataka, INDIA.

geetha@appbot.uni-mysore.ac.in

Received: 01-05-2025; Revised: 30-06-2025; Accepted: 18-08-2025.

Volume 60, Issue 2S · pp. s533–s540 · PUBLISHED · DOI: 10.5530/ijper.20261603

View on IJPER original site ↗

ABSTRACT

Background:Breast cancer is a predominant disease around the world, with early diagnosis aiding in reducing the spread and recurrence. Plant-mediated nanoparticles have shown promising results in treatment. The current study aimed to synthesize Magnetite Nanoparticles (MNPs) utilizing Piper betle var. Mysuru extract and evaluate its anti-breast cancer potentials. Materials and Methods: The green synthesis included Fe3+ and Fe2+ in a 2:1 proportion, with crude ethyl acetate extract as a reducing, stabilizing, capping, and tailing agent. The MNPs were characterized utilizing UV-vis spectrometry, SEM, EDX, XRD, FTIR, and DLS for various properties like size, crystal structures, presence of functional groups, surface topologies, etc. Results:The diameter of the newly synthesized nanoparticle was 90 nm in diameter, with a face-centered crystal lattice with different phytochemicals like alcohol, phenols, alkanes, etc. The cytotoxicity assay showed IC50 values of Doxorubicin, plant extract, and MNPs to be 16.77±0.56 μg/mL, 26.07±3.14 μg/mL, and 12.35±2.47 μg/mL, respectively. The hemolytic assay showed 8.8% and 12.28% hemolytic activity with plant extract and MNPs, respectively. Conclusion:The MNPs' affordability, Eco-friendliness, and ease of synthesis make them ideal candidates for upscale synthesis to be used as an active drug molecule against breast cancer.

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    Shekhar, R., Prakash, H. S., & Geetha, N. (). Phytofabrication of Magnetite Nanoparticles from Piper betle (L.) var. Mysore and Evaluation of Anti-Breast Cancer Potentials. Indian Journal of Pharmaceutical Education and Research, 60(2S), s533–s540. https://doi.org/10.5530/ijper.20261603