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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Inhibition of miR-224 Repressed Cell Growth, Migration and Invasiveness in Gastric Cancer

Changming Shao1★, Qinshu Shao2, Qinshu Shao3★ Corresponding author

  1. 1Department of Vascular Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, CHINA.
  2. 2Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, CHINA.
  3. 3Clinical Research Institute, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, CHINA.

CORRESPONDENCE

Changming Shao

Department of Vascular Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, CHINA.

2515033@zju.edu.cn

Received: 08-02-2025; Revised: 24-02-2026; Accepted: 15-04-2026.

Volume 60, Issue 3 · pp. 1218–1223 · PUBLISHED 2026 · DOI: 10.5530/ijper.20263262

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ABSTRACT

Aim/Background: MiR-224 has been reported to be associated with many cancers, however, the role of miR-224 in gastric cancer was unclear. Materials and Methods: In the present study, we first used RT-PCR to detect miR-224 level in gastric cancer fresh tissue. Then we performed miR-224 inhibitor transfection in gastric cancer cells, and MTT, cell invasion and migration and colony formation were performed to explore the role of miR-224 in gastric cancer in vitro. Results: The results showed that the relative level of miR-224 in human gastric cancer tissue was significantly higher than that in the adjacent non-tumor gastric mucosa. After transfected by miR-224 inhibitor, the gastric cancer cell proliferation rate was lower compared with the control group, and the migration and invasion are also inhibited by miR-224 inhibitors. The colony number of gastric cancer cells transfected with miR-224 inhibitors was significantly lower than that of the control group. Conclusion: Our results demonstrated that miR-224 is upregulated in gastric cancer. miR-224 inhibitors repressed the proliferation, migration, invasion and colony formation capacity of gastric cancer cells, which indicated that inhibition of miR-224 might be a promising therapeutic option for human gastric cancer.

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    Shao, C., Shao, Q., & Shao, Q. (2026). Inhibition of miR-224 Repressed Cell Growth, Migration and Invasiveness in Gastric Cancer. Indian Journal of Pharmaceutical Education and Research, 60(3), 1218–1223. https://doi.org/10.5530/ijper.20263262