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Indian Journal of Pharmaceutical Education and ResearchNOW IN
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IJPER · Lens · Floating Extended Release Tablets of Tenofovir Formulation and Design by Central Composite Design (CCD) Using Cetyl Alcohol as Floating Assistant

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Article · Volume 60, Issue 3S · pp. s–s

Floating Extended Release Tablets of Tenofovir Formulation and Design by Central Composite Design (CCD) Using Cetyl Alcohol as Floating Assistant

Challa Taraka Ramarao1, Siba Patri1

  1. 1Department of Pharmaceutical Technology, Sri Venkateswara College of Pharmacy, Etchrela, Srikakulam, Andhra Pradesh, INDIA.

Abstract

Introduction: The Tenofovir (TFR) is a BCS Class III widely prescribed treatment of HIV and Hepatitis.Materials and Methods: The CCD was used to statistically optimization parameters and evaluate on the efficacy of gastro retentive floating behaviour. The concentration of HPMC K100 M (X1), Cetyl Alcohol (X2) and Ethyl Cellulose (X3) were selected independent variables. To determine the following: drug release kinetics, counter and 3D surface plots, in vitro dissolution and comparison of TenoHep with optimized and F1 Formulation, swelling-erosion index, floating attributes and tablet properties.Results: The formulation R2 was higher when fitted to zero order equation which indicates that a zero order release, except F12 as first order.Conclusion: The optimization floating is well suitable for gastro retentive following extend release.

Keywords: TenoHep; Tenofovir; Floating; Optimization; In vitro

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