Floating Extended Release Tablets of Tenofovir Formulation and Design by Central Composite Design (CCD) Using Cetyl Alcohol as Floating Assistant

ABSTRACT

Introduction: The Tenofovir (TFR) is a BCS Class III widely prescribed treatment of HIV and Hepatitis. Materials and Methods: The CCD was used to statistically optimization parameters and evaluate on the efficacy of gastro retentive floating behaviour. The concentration of HPMC K100 M (X1), Cetyl Alcohol (X2) and Ethyl Cellulose (X3) were selected independent variables. To determine the following: drug release kinetics, counter and 3D surface plots, in vitro dissolution and comparison of TenoHep with optimized and F1 Formulation, swelling-erosion index, floating attributes and tablet properties. Results: The formulation R2 was higher when fitted to zero order equation which indicates that a zero order release, except F12 as first order. Conclusion: The optimization floating is well suitable for gastro retentive following extend release.

KEYWORDS

• TenoHep
• Tenofovir
• Floating
• Optimization
• In vitro

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• DOI10.5530/ijper.20262471Copy

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