Formulation and Evaluation of Beclomethasone Dipropionate Loaded Niosomal Gel for Topical Use

ABSTRACT

Background: The present study focuses on the formulation and evaluation of a niosomal gel containing beclomethasone dipropionate for topical delivery, with the objective of enhancing skin permeability and achieving sustained drug release. Niosomes, which are spherical vesicles composed of non-ionic surfactants, offer several advantages over conventional drug delivery systems, including higher drug loading capacity, controlled release, and reduced systemic side effects. Materials and Methods: In this study, niosomes were prepared using the thin-film hydration technique by optimizing the ratios of Span 60 and cholesterol. The prepared niosomal dispersions were subsequently incorporated into a Carbopol-based gel and subjected to comprehensive evaluation. Evaluation Parameters: Various parameters, including vesicle size, entrapment efficiency, pH, spreadability, drug content, and in vitro drug release, were assessed. Results/Conclusion: The results demonstrated that the optimized niosomal gel possessed favorable physicochemical properties, exhibited sustained drug release, and showed significant potential as an effective topical drug delivery system.

KEYWORDS

• Carbopol gel
• Controlled Release
• Niosomes
• Non-ionic Surfactants
• Thin-Film
• Hydration Method
• Topical Drug Delivery

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• DOI10.5530/ijper.20260326Copy

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