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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Nanoemulsion-Based Delivery System for Naftifine Hydrochloride: A Promising Approach for Solubility Enhancement

Kajal Sunil Shinde1★, Chandrapraphu Motichand Jangme2, Abhinandan Raosaheb Patil3★ Corresponding author

  1. 1Department of Pharmaceutical Science, Centre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, INDIA.
  2. 2Department of Pharmacology, D. Y. Patil College of Pharmacy, D. Y. Patil Education Society, Deemed to Be University, Kolhapur, Maharashtra, INDIA.
  3. 3Department of Pharmaceutics, D. Y. Patil College of Pharmacy, D. Y. Patil Education Society, Deemed to Be University, Kolhapur, Maharashtra, INDIA.

CORRESPONDENCE

Kajal Sunil Shinde

Department of Pharmaceutical Science, Centre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, INDIA.

kajalshinde893@gmail.com

Received: 18-12-2026; Revised: 25-02-2026; Accepted: 08-04-2026.

Volume 60, Issue 3S · pp. s944–s953 · PUBLISHED 2026 · DOI: 10.5530/ijper.20262145

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ABSTRACT

Aim/Background: Naftifine hydrochloride, a BCS Class IV antifungal agent, suffers from poor aqueous solubility, limiting its therapeutic efficacy. This study aims to enhance its solubility using a nanoemulsion-based drug delivery system. Materials and Methods: A systematic formulation approach identified oleic acid, Kolliphor® RH40, and Transcutol-P® as optimal components. Pseudo ternary phase diagrams have been utilized to identify and select the optimal emulsification zone and a 3² factorial design optimized the formulation. Results: The nanoemulsion demonstrated improved solubility, thermodynamic stability, and uniform globule size. Conclusion: These results indicate that nanoemulsion technology holds great potential for improving both the solubility and bioavailability of Naftifine hydrochloride for effective topical antifungal therapy.

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    Shinde, K. S., Jangme, C. M., & Patil, A. R. (2026). Nanoemulsion-Based Delivery System for Naftifine Hydrochloride: A Promising Approach for Solubility Enhancement. Indian Journal of Pharmaceutical Education and Research, 60(3S), s944–s953. https://doi.org/10.5530/ijper.20262145