Volume 60, Issue 3S

2026 · pp. s1351–s1363 · 45 articles

Volume: 60
Issue: 3S
Published: 2026
Pages: s1351–s1363
Articles: 45
Sections: 2
ISSN: Online - 0019-5464
Journal: IJPER

Original Article Review Article

In this issue

Original Article

Article
Development and evaluation of Dry Powder Inhalation Formulation of Remdesivir Nanosuspension by Spray Drying Technique
Arshad Shaikh, Mukesh Pandurang Ratnaparkhi, Sayali Vilas Jadhav, Shailendra Salvankar
pp. s1–s9 · DOI: 10.5530/ijper.20263050 · Published 2026
Introduction: Significant global health issues are caused by respiratory viral infections, such as COVID-19, which call for effective and focused drug delivery methods to improve treatment effectiveness and lessen system…
Article
Optimized Green Synthesis Approaches of Phenytoin Using Divalent Sulfate Salts and Chromatographic Purity Assessment via A Novel RP-HPLC Method
Arka Chakraborty, Rajarshi Nath, Biplab Debnath, Arijit Das, Anindya Bose, Shambo Panda
pp. s1–s8 · DOI: 10.5530/ijper.20262650 · Published 2026
Background: Phenytoin is a first-line anti-epileptic drug. Conventionally, It is synthesized by using Benzil and urea in the presence of concentrated HCl. Our aim is to increase the yield as well as the purity of Phenyto…
Article
Formulation and Evaluation of Beclomethasone Dipropionate Loaded Niosomal Gel for Topical Use
Mahesh Birajdar, Rohit Sarda, Shradha Tiwari, Dnyaneshwari Jadhav, Sameep Sonvane, Prakash Shivnechari, Kranti Satpute
pp. s918–s928 · DOI: 10.5530/ijper.20260326 · Published 2026
Background: The present study focuses on the formulation and evaluation of a niosomal gel containing beclomethasone dipropionate for topical delivery, with the objective of enhancing skin permeability and achieving susta…
Article
Design and Development of Self-Micro Emulsifying Drug Delivery Systems of Rifaximin Using 32 Factorial Design
Onkar Vilas Jadhav, Twarita Dilip Deshpande, Udaykumar Baburao Bolmal, Anuj Jagannath Shinde, Shital Vishwas Patil
pp. s929–s943 · DOI: 10.5530/ijper.20263168 · Published 2026
Aim/Background: This study aimed to enhance the oral bioavailability of Rifaximin by formulating a Self-Micro emulsifying Drug Delivery System, with the goal of improving its aqueous solubility and dissolution performanc…
Article
Nanoemulsion-Based Delivery System for Naftifine Hydrochloride: A Promising Approach for Solubility Enhancement
Kajal Sunil Shinde, Chandrapraphu Motichand Jangme, Abhinandan Raosaheb Patil
pp. s944–s953 · DOI: 10.5530/ijper.20262145 · Published 2026
Aim/Background: Naftifine hydrochloride, a BCS Class IV antifungal agent, suffers from poor aqueous solubility, limiting its therapeutic efficacy. This study aims to enhance its solubility using a nanoemulsion-based drug…
Article
Development and Optimization of a Super Saturable Self-Nanoemulsifying Drug Delivery System for Ibrutinib: Enhancing Solubility and Anticancer Potential
Vyshali Parigela, Vijayalakshmi Arumugam
pp. s954–s969 · DOI: 10.5530/ijper.20262420 · Published 2026
Aim: This study explores the development and optimization of a Super saturable Self-Nanoemulsifying Drug Delivery System to enhance the solubility, bioavailability, and anticancer efficacy of ibrutinib. Materials and Met…
Article
Nanostructured Lipid Carrier-Based Hydrogel of Fenoprofen Calcium for Sustained Release: Optimization, Characterisation, and in vitro Evaluation
Ishrat Zahoor, Neelam Sharma, Sukhbir Singh
pp. s970–s981 · DOI: 10.5530/ijper.20262181 · Published 2026
Objectives: Fenoprofen Calcium (FEN) has short elimination half-life, frequent dosage administration and numerous gastrointestinal side effects on oral administration. The primary objective of this research was to synthe…
Article
Formulation and Evaluation of HPMC Phthalate Succinate-based Tablets of Tolvaptan: In vitro Evaluation
Nagella Raveendra Babu, Rajendra Awasthi, Dhawal Ankola, Dheeraj Nagpal
pp. s982–s995 · DOI: 10.5530/ijper.20262449 · Published 2026
Aim: This study aimed to evaluate the performance of novel Hydroxy Propyl Methyl Cellulose Phthalate Succinate polymers (HPMCPS) as alternatives to Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS) and other polym…
Article
Combination of Ginseng and Curcumin Loaded Polymeric Nanoparticles: A Novel Approach to Check Synergistic Effect for the Topical Treatment of Diabetic Retinopathy
Umesh Laddha, Kailas Moravkar, Neelam Dashputre, Yatin Gadkari, Sachin Gaikwad, Sanjay Kshirsagar
pp. s996–s1003 · DOI: 10.5530/ijper.20262651 · Published 2026
Background: Diabetic Retinopathy (DR) is the worst complication of diabetes which is treated by the invasive methods. The proposed study involves the development of novel combinational therapy for the topical management …
Article
Design of Experiments (DoE)-Based Optimization of Pomalidomide Nanosuspension for Improved Oral Absorption and Pharmacokinetics
Shaik Sabiha Thabbssum, Darna Bhikshapathi, Pavan Kumar Jaini, Medipally Viswaja, Mohammed Apsar Pasha
pp. s1024–s1036 · DOI: 10.5530/ijper.20262826 · Published 2026
Aim: The study aims to enhance the oral bioavailability and solubility of Pomalidomide (POM), which is classified as a class IV medication based on the Biopharmaceutical Classification System (BCS). Materials and Methods…
Article
Optimization of Linagliptin and Valsartan Bilayer Tablets Using Quality by Design
Dong Hyeok Kim, Chul Yong Bae, Shugeng Cao, Jae Sung Pyo, Yeun Hee Kim, Kang Min Kim
pp. s1046–s1055 · DOI: 10.5530/ijper.20264282 · Published 2026
Background and Objectives: The development of a bilayer tablet containing valsartan and linagliptin requires precise control of formulation and process variables to ensure consistent product quality. This study aimed to …
Article
Formulation and Evaluation of Sodium Hyaluronate – Triphala Ophthalmic Emulsion for Treatment of Computer Vision Syndrome
Hrithik Satish Revankar, Shilpa Bhilegaonkar
pp. s1056–s1069 · DOI: 10.5530/ijper.20263704 · Published 2026
Background: Computer vision syndrome is a eye condition linked to long periods of screen use. Early signs include irritation, redness and dryness. Chronic cases can lead to serious issues like high myopia, vitreous float…
Article
Cardioprotective Effect of Apigenin-Hydroxyapatite Nanocomposite against H2O2-Induced Injury in Cardiomyoblast Cells
Hafiz Makeen, Mohammad Albratty
pp. s1070–s1086 · DOI: 10.5530/ijper.20264260 · Published 2026
Background: Cardiovascular diseases remain the leading cause of mortality worldwide, largely driven by oxidative stress and inflammation during myocardial ischemia and reperfusion injury. Apigenin, a natural flavonoid, e…
Article
Comparative Evaluation of the Anticancer Efficacy of Fluoroquinolone Antibiotics Across Diverse Cancer Cell Lines
Durgesh Soni, Mohd Hasan Mujahid, Vijay Jagdish Upadhye
pp. s1087–s1104 · DOI: 10.5530/ijper.20262146 · Published 2026
Background: Cancer treatment faces significant challenges due to limited success with conventional therapies. Drug repurposing-identifying new applications for existing drugs—offers a promising strategy to expand therape…
Article
Synthesis Characterization of Sulphadiazine Scaffold: In silico and in vitro Antibacterial Activity
Ramakrishna Chintakunta, Harshitha Shivakumar, Sonapriyadarshini Palanikumar, Lokesh Boobal, Bharath Abbaiahreddy, Sathya Prakash Sekar
pp. s1105–s1112 · DOI: 10.5530/ijper.20263176 · Published 2026
Aim: The present study involves the synthesis, characterization, and evaluation of six novel Sulphadiazine derivatives (SV1-SS6) using Schiff base reactions with various aromatic aldehydes. Materials and Methods: The com…
Article
Computational Pharmacokinetics and Docking Insights into Conjugated Schiff Base Scaffold for Acetylcholinesterase Inhibition
Blessy Jacob, Sarita Karole
pp. s1113–s1119 · DOI: 10.5530/ijper.20263952 · Published 2026
Aim: To evaluate the pharmacokinetic profiles and docking interactions of Schiff base scaffolds as potential Acetylcholinesterase (AChE) inhibitors using computational models. Background: Schiff bases exhibit diverse bio…
Article
In vivo and in vitro Comparative Evaluation of Delphinium denudatum and Amaranthus spinosus for Anticonvulsant Activity
Mohd Abid, Shamim Shamim, Shadab Ali, Jiyaul Hak
pp. s1120–s1128 · DOI: 10.5530/ijper.20262896 · Published 2026
Introduction: 50 million people worldwide are affected by epilepsy, and a significant proportion suffer from side effects or respond poorly to drugs. With an established use in neurology, Delphinium denudatum (DDE) and A…
Article
Therapeutic Effects of a Polyherbal Formulation on Metabolic Dysregulation in Type 2 Diabetic Rats by LCMS
Deepak Kumar Jha, Anushree Vabasandra Byregowda
pp. s1129–s1138 · DOI: 10.5530/ijper.20263031 · Published 2026
Aim and Objectives: This study examined the effects of a polyherbal formulation (composite of Camellia sinensis, Cinnamomum verum, Syzygium aromaticum, Curcuma longa, and Elettaria cardamomum) on lipid and glucose metabo…
Article
Lentinula edodes Polysaccharides Inhibit Estrogen Biosynthesis Enzymes in Hormone-Dependent Breast Cancer
Chandrasekaran Ponnusamy, V V Sathibabu Uddandrao, Vadivukkarasi Sasikumar, Puniethaa Prabhu, Saravanan Ganapathy
pp. s1139–s1155 · DOI: 10.5530/ijper.20263074 · Published 2026
Background / Objective: Breast cancer, a leading cause of death among women, is closely associated with estrogen metabolism. This study investigated the potential of partially purified polysaccharides from Lentinula edod…
Article
Ethnobotanical Survey on Antidiabetic Medicinal Plants in Western Algeria: Traditional Knowledge and Public Health Implications
Nadia Chelli, Foufa Bouabsa, Hamida Benfreha, Aicha Tir Touil, Boumediene Meddah
pp. s1156–s1169 · DOI: 10.5530/ijper.20261753 · Published 2026
Background: Type 2 diabetes is a global health challenge with significant socio-economic impacts, particularly in Algeria. Medicinal plants offer an affordable and accessible alternative to pharmaceutical treatments. Thi…
Article
Spectrometric and Chromatographic Profiling of Naringin from Citrus reticulata Blanco, Native to the Himalayan Region of Darjeeling and Sikkim
Vishala Rani Baraily, Bhupendra Shrestha, Jithendar Reddy Mandhadi
pp. s1170–s1179 · DOI: 10.5530/ijper.20263469 · Published 2026
Aim: Citrus reticulata Blanco (CRB), widely cultivated in the Himalayan regions of Darjeeling and Sikkim, is a remarkable source of bioactive flavonoids, particularly naringin. This study presents the methodical effort t…
Article
Evaluation of Toxicity and Anti-Breast Cancer Potential of Methanolic Leaf Extract of Anastatica hierochuntica in DMBA Induced Rat Model
Saranya Rameshbabu, Safia A. Messaoudi, Abrar B. Alsaleh, Mary Anne Wong Cordero, Kavitha Ganesh, Najwa Abdur Rashid, Raja El Hasnaoui- Saadani, Syed Ali Mohamed Yacoob
pp. s1180–s1193 · DOI: 10.5530/ijper.20263332 · Published 2026
Background: Anastatica hierochuntica has been traditionally used in herbal medicine for its therapeutic effects, but its safety and efficacy have not been comprehensively assessed. This study investigated the Methanolic …
Article
Evaluation of Berberis aristata Extract and Berberine for Anti-Oral Cancer Potential
Vijaya Vichare, Manasi Rokade, Vaishnavi Ithape, Vrushali Tambe, Dhole Shashikant, Choudhari Vishnu
pp. s1194–s1202 · DOI: 10.5530/ijper.20265938 · Published 2026
Background: Traditional ayurveda medication Berberis aristata possesses a wide range of biological activities, including antipyretic, anti-inflammatory, anti-diabetic, and anticancer, etc. Protoberberine, berberine, and …
Article
Extraction, Phytochemical Analysis, and Antioxidant Activity of Adhatoda vasica Leaves
Hameed Fathima Kamal, Jaideep Mahendra, Ashok Kumar Pandurangan
pp. s1203–s1214 · DOI: 10.5530/ijper.20264592 · Published 2026
Background: Adhatoda vasica is a well-known medicinal plant with diverse therapeutic properties, widely used in traditional medicine. Its phytochemical composition and antioxidant potential warrant detailed investigation…
Article
Insulin-Sensitizing Effect of Buchanania lanzan Leaf Extract: Integrated Computational and in vivo Evidence
Rubina Usman Watangi, Nayeem Ashrafali Khatib, Sunil Tuakaram Galatage, Arehalli Sidramappa Manjappa, Tufailahmad Basheerahmad Sajjan, Ekta Uday Kotharkar, Rajkumar Sanjay Patil
pp. s1215–s1230 · DOI: 10.5530/ijper.20264345 · Published 2026
Background: Buchanania lanzan Spreng. is a plant having anti-diabetic, anti-inflammatory properties. Aim: The aim of this research is to assess methanolic extract of Buchanania lanzan leaves for insulin sensitivity in di…
Article
Antidiabetic and Hepatoprotective Effects of Dichrostachys cinerea Bark Extract in Streptozotocin-Induced Diabetic Rats
Suha Mujahed Abudoleh, Qais Abualassal, Zead Helmi Abudayeh, Zain Alabden Ghanim Ahmed Ahmed, Samer Hasan Hussein-Al-Ali, Kowsalya Ramalingam, Shilpa Perumal Narasimhamoorthi, Palanisamy Arulselvan, Karunakaran Saravanan, Subbarayan Sarathbabu
pp. s1231–s1239 · DOI: 10.5530/ijper.20263929 · Published 2026
Background: Diabetes mellitus is a complex metabolic disorder characterized by chronic hyperglycemia resulting from impaired insulin secretion, insulin action, or both. Persistent hyperglycemia is often accompanied by se…
Article
Drug-Excipients Compatibility Studies of Molnupiravir in an Attempt of Developing a Stable Molnupiravir Capsule Formulation for the Treatment of COVID-19
Sumit Agarwal, Rajasekaran Sidhan
pp. s1240–s1245 · DOI: 10.5530/ijper.20262891 · Published 2026
Background: Molnupiravir is an antiviral medication primarily used for the treatment of COVID-19. Clinical trials have shown that molnupiravir reduces the risk of hospitalization and death due to COVID- 19 when taken ear…
Article
Fabrication of a Cost-Effective in-House Electrode Assembly for Recording EEG and Behavioral Seizures in Unrestrained Rats
Nitin Yadav, Radhika Mittal, Arzoo Chaudhary, Priya Priya, Jyotirmoy Banerjee, Aparna Banerjee Dixit
pp. s1246–s1252 · DOI: 10.5530/ijper.20263671 · Published 2026
Background: Electroencephalography (EEG) is a valuable tool in neuroscience research for analyzing epileptic seizures in animal models. However, the cost that comes with commercial electrode assemblies is a critical chal…
Article
Establishment of a Sensitive and Stability-Indicating RP-HPLC Protocol for Co-Quantification of Empagliflozin and Sitagliptin
Rahil Desai, Mitali Dalwadi, Umesh Upadhyay
pp. s1261–s1266 · DOI: 10.5530/ijper.20262811 · Published 2026
Aim/Background: To develop a stability-indicating RP-HPLC method for simultaneous quantification of Empagliflozin (EMPA) and Sitagliptin (SITA) in a synthetic mixture for quality control and stability studies. Materials …
Article
QbD-Driven Hydrotropic UV Method for Simultaneous Quantitation of Poorly Soluble Drugs, Irbesartan and Hydrochlorothiazide in Bulk and Tablet Formulation
Aggarapu Susmitha, Galla Rajitha
pp. s1267–s1278 · DOI: 10.5530/ijper.20261652 · Published 2026
Background: Developing a reliable and precise method for the simultaneous quantitation of poorly soluble drugs, Irbesartan (IRB) and Hydrochlorothiazide (HCTZ), in bulk and formulations poses significant challenges due t…
Article
QbD Assisted Method Development and Validation of Stability Indicating UV Spectrophotometric Method for Azelnidipine
Kirankumar Jalindar Gavali¹, Meenaxi Maruti Maste¹, Nikhil Sunil Gawas¹, Shailendra Sanjay Suryawanshi²
pp. s1285–s1298 · DOI: 10.5530/ijper.20261963 · Published 2026
Background: Azelnidipine, calcium channel blocker used in hypertension management, requires reliable analytical method to ensure its stability, quality, and regulatory compliance. Stability-indicating methods are essenti…
Article
Analytical Verification and Studies on Degradation of Voglibose Nanocrystals Formulations using the Quantitative RP-HPLC Method
Preeti Aneja, Rajender Guleria, Dev Praksh Dahiya, Mohanraj Swaminathan
pp. s1299–s1309 · DOI: 10.5530/ijper.20262024 · Published 2026
Introduction: The primary goal of the experiment was to validate a method for identifying Voglibose content in a newly developed Nano formulation specifically Nanocrystals. For estimating the content of voglibose in drug…
Article
Novel and Simple LC-MS/MS Technique for the Simultaneous Quantitation of Metformin and Remogliflozin in Rat Plasma
Smit Jayantilal Patel, Hiralben Mehta, Basheer Ahmmad Shaik, Nadeem Khan
pp. s1310–s1319 · DOI: 10.5530/ijper.20263379 · Published 2026
Background: Metformin and remogliflozin in fixed dose combination prescribe to control blood sugar and avoid long term complication associated with diabetes mellitus. Aim: The aim is to establish a straightforward and se…
Article
Development of Novel RP-HPLC and Chromogenic UV-Visible Methods for the Estimation of Sitagliptin Using NQS in Bulk and Biological Samples in Compliance with ICH M10 and Q2(R2) Guidelines
Khagga Bhavya Sri, Tailors Keerthana, Jinkala Pravallika, Mogili Sumakanth
pp. s1320–s1330 · DOI: 10.5530/ijper.20263258 · Published 2026
Aim: This study develops and validates two analytical methods: An innovative UV-visible chromogenic spectrophotometric method applied to bio-samples and a (RP-HPLC) High-performance liquid chromatography method in revers…
Article
A Randomized Controlled Trial Assessing the Effects of a Pharmacist-Led Educational Pharmaceutical Care Program on Clinical and Self-Management Outcomes in Type 2 Diabetes Mellitus Patients in Gujarat, India
Rishita. D Patel, Harsha V. Patel
pp. s1331–s1340 · DOI: 10.5530/ijper.20263193 · Published 2026
Objectives: The objective of the pharmacist-led educational Pharmaceutical Care Intervention Program (PLEPCIP) was to evaluate its effect on glycemic control, as measured by HbA1c levels, in patients with type 2 diabetes…
Article
Understanding Consumer Adoption of e-Pharmacy in India: The Role of Gender, Generation, Profession, and Area of Living
Saptaparni Roy Chowdhury, Jayeeta Majumder, Sourav Gangopadhyay
pp. s1341–s1350 · DOI: 10.5530/ijper.20263391 · Published 2026
Background: Convenience, accessibility and affordability are the three constructs that is attracting consumers to transform the healthcare landscape digitally into adoption of e-pharmacy. This research study probes into …
Article
Quantification and Spectral Interference Studies of Selected Weak Chromophore Molecules Using ATR-FTIR Spectroscopy with Regression Tools
Jia Ying Lee, Amira Teoh Binti Mohd Shukri Teoh, Bontha Venkata Subrahmanya Lokesh, Preeti Bala Shrivastava
pp. s1351–s1363 · DOI: 10.5530/ijper.20262387 · Published 2026
Background: Weak chromophore molecules present challenges in analytical method development for routine quality control testing. This study focuses on three such molecules: favipiravir and molnupiravir, antiviral drugs re…
Article
Floating Extended Release Tablets of Tenofovir Formulation and Design by Central Composite Design (CCD) Using Cetyl Alcohol as Floating Assistant
Challa Taraka Ramarao, Siba Patri
pp. s–s · DOI: 10.5530/ijper.20262471 · Published 2026
Introduction: The Tenofovir (TFR) is a BCS Class III widely prescribed treatment of HIV and Hepatitis. Materials and Methods: The CCD was used to statistically optimization parameters and evaluate on the efficacy of gast…
Article
Validation of Effective β-Lactum Antibiotics in Available Dosage Forms by RP-HPLC Developed Analytical Chromatographic Method
Suchitra Duddagi, Shravan Kumar Konda, Jagadish Tota, Shushma Akula, Pavan Kumar Kasu
pp. s–s · DOI: 10.5530/ijper.20261898 · Published 2026
Background: Vaborbactam and Meropenem are co-formulated in pharmaceutical tablets for enhanced antibacterial activity. A simple, economical, and reliable analytical method is required for their simultaneous quantificatio…
Article
Synthesis and Evaluation of Triphenylphosphonium- Pluronic F127 Conjugate for Enhanced Mitochondrial Targeting in Drug Delivery Systems
Archita Katrolia, Rohit Singh, Vikesh Kumar Shukla
pp. s–s · DOI: 10.5530/ijper.20262468 · Published 2026
Background: Mitochondria, often termed the "powerhouse of the cell", have increasingly become a focal point for the targeted delivery of therapeutic agents in the treatment of various metabolic disorders. This emerging f…

Review Article

Review
Role of Staple Food Fortification in Combating Micronutrient Deficiency
Sindhu Abraham, Sharon Furtado, Amruthavarshini SN, Suman C
pp. s864–s873 · DOI: 10.5530/ijper.20263666 · Published 2026
Micronutrient deficiencies, often referred to as “hidden hunger,” result from a dearth of vital nutrients and minerals in the diet, causing malnutrition. The mortality rate of children under the age of five is high in In…
Review
Advances in Green Bromination: Emerging Eco-Friendly Reagents and Methodologies
Vidya Kishanrao Magar, Karna Bhagwanrao Khavane, Sameena Ibrahim Shaikh, Dipali Vishwanath Sangule, Santosh Dattatraya Shelke
pp. s874–s881 · DOI: 10.5530/ijper.20263230 · Published 2026
In light of the growing emphasis on sustainable practices in modern chemistry, this review critically examines recent advancements in environmentally benign methods for the bromination of organic compounds. Bromination, …
Review
Insight into the Recent Advancement of 1,3,4 Oxadiazoles as Potential EGFR and Telomerase Inhibitory for Anticancer Activity
Ayush Jain, Chandana Majee, Rupa Mazumder, Avijit Mazumder
pp. s882–s895 · DOI: 10.5530/ijper.20261459 · Published 2026
Cancer is acknowledged as one of most perilous diseases, with significant challenges associated with existing anticancer therapies, including issues of drug resistance, narrow therapeutic windows, and the manifestation o…
Review
Gold Nanoparticles: Innovative Supramolecular Platforms for Targeted Drug Delivery and Bioorthogonal Catalysis
Anil Pawar, Alka Zade, Aarti Shastri, Ramesh Ingole, Sagar Kharde, Jeevan Rajguru
pp. s896–s905 · DOI: 10.5530/ijper.20261157 · Published 2026
Gold Nanoparticles (AuNPs) have gained significant attention across multiple fields, including drug delivery, therapy, sensing, material science and catalysis, due to their tunable properties. These nanoparticles exhibit…
Review
Recent Advances in Phytoconstituent-Based Alpha Glucosidase Inhibitors and Therapeutic Potential for Type 2 Diabetes Mellitus
Tarmeen Ali, Ganesh Prasad Mishra
pp. s906–s917 · DOI: 10.5530/ijper.20262117 · Published 2026
Type 2 Diabetes Mellitus is a chronic metabolic disorder characterized by insulin resistance and impaired glucose metabolism. Alpha-glucosidase inhibitors have emerged as a promising therapeutic approach to managing post…