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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Review

Advances in Green Bromination: Emerging Eco-Friendly Reagents and Methodologies

Vidya Kishanrao Magar1★, Karna Bhagwanrao Khavane2, Sameena Ibrahim Shaikh1, Dipali Vishwanath Sangule1, Santosh Dattatraya Shelke1★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, Srinath College of Pharmacy Bajaj Nagar, Waluj, Chhatrapati Sambhajinagar, Wadgaon Kolhati, Maharashtra, INDIA.
  2. 2Department of Pharmacology, Dr. Vedprakash Patil Pharmacy College, Chh. Sambhajinagar, Maharashtra, INDIA.

CORRESPONDENCE

Vidya Kishanrao Magar

Department of Pharmaceutical Chemistry, Srinath College of Pharmacy Bajaj Nagar, Waluj, Chhatrapati Sambhajinagar, Wadgaon Kolhati, Maharashtra, INDIA.

vidyamagar87@gmail.com

Received: 11-12-2025; Revised: 08-02-2026; Accepted: 22-04-2026.

Volume 60, Issue 3S · pp. s874–s881 · PUBLISHED 2026 · DOI: 10.5530/ijper.20263230

View on IJPER original site ↗

ABSTRACT

In light of the growing emphasis on sustainable practices in modern chemistry, this review critically examines recent advancements in environmentally benign methods for the bromination of organic compounds. Bromination, a transformation of significant synthetic and industrial relevance, has traditionally relied on harsh reagents and conditions that raise environmental and safety concerns. This review focuses on "green" strategies developed for the selective introduction of bromine atoms into organic molecules, encompassing both direct bromination and oxidative bromination methodologies. Emphasis is placed on approaches that minimize hazardous waste, utilize safer brominating agents, and operate under milder reaction conditions. Particular attention is given to catalytic systems, solvent-free protocols, aqueous media, and the use of renewable feedstock’s. Each method is evaluated not only for its synthetic efficiency and selectivity but also through the lens of sustainability metrics, including atom economy, energy efficiency, and environmental impact. By compiling and analyzing recent literature, this review aims to provide a comprehensive understanding of current progress and remaining challenges in the field of green bromination chemistry.

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    Magar, V. K., Khavane, K. B., Shaikh, S. I., Sangule, D. V., & Shelke, S. D. (2026). Advances in Green Bromination: Emerging Eco-Friendly Reagents and Methodologies. Indian Journal of Pharmaceutical Education and Research, 60(3S), s874–s881. https://doi.org/10.5530/ijper.20263230