Article · Volume 60, Issue 3S · pp. s918–s928

Formulation and Evaluation of Beclomethasone Dipropionate Loaded Niosomal Gel for Topical Use

Mahesh Birajdar¹, Rohit Sarda¹, Shradha Tiwari², Dnyaneshwari Jadhav¹, Sameep Sonvane¹, Prakash Shivnechari¹, Kranti Satpute¹

¹Dayanand Education Society’s, Dayanand College of Pharmacy, Barshi Road, Latur, Maharashtra, INDIA.
²School of Pharmacy, MIT Vishwaprayag University, Solapur-Pune Highway, Kegaon, Solapur, Maharashtra, INDIA.

Abstract

Background: The present study focuses on the formulation and evaluation of a niosomal gel containing beclomethasone dipropionate for topical delivery, with the objective of enhancing skin permeability and achieving sustained drug release. Niosomes, which are spherical vesicles composed of non-ionic surfactants, offer several advantages over conventional drug delivery systems, including higher drug loading capacity, controlled release, and reduced systemic side effects.Materials and Methods: In this study, niosomes were prepared using the thin-film hydration technique by optimizing the ratios of Span 60 and cholesterol. The prepared niosomal dispersions were subsequently incorporated into a Carbopol-based gel and subjected to comprehensive evaluation. Evaluation Parameters: Various parameters, including vesicle size, entrapment efficiency, pH, spreadability, drug content, and in vitro drug release, were assessed. Results/Conclusion: The results demonstrated that the optimized niosomal gel possessed favorable physicochemical properties, exhibited sustained drug release, and showed significant potential as an effective topical drug delivery system.

Keywords: Carbopol gel; Controlled Release; Niosomes; Non-ionic Surfactants; Thin-Film; Hydration Method; Topical Drug Delivery

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