Article · Volume 60, Issue 3S · pp. s944–s953

Nanoemulsion-Based Delivery System for Naftifine Hydrochloride: A Promising Approach for Solubility Enhancement

Kajal Sunil Shinde¹, Chandrapraphu Motichand Jangme², Abhinandan Raosaheb Patil³

¹Department of Pharmaceutical Science, Centre for Interdisciplinary Research, D. Y. Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, INDIA.
²Department of Pharmacology, D. Y. Patil College of Pharmacy, D. Y. Patil Education Society, Deemed to Be University, Kolhapur, Maharashtra, INDIA.
³Department of Pharmaceutics, D. Y. Patil College of Pharmacy, D. Y. Patil Education Society, Deemed to Be University, Kolhapur, Maharashtra, INDIA.

Abstract

Aim/Background: Naftifine hydrochloride, a BCS Class IV antifungal agent, suffers from poor aqueous solubility, limiting its therapeutic efficacy. This study aims to enhance its solubility using a nanoemulsion-based drug delivery system.Materials and Methods: A systematic formulation approach identified oleic acid, Kolliphor® RH40, and Transcutol-P® as optimal components. Pseudo ternary phase diagrams have been utilized to identify and select the optimal emulsification zone and a 3² factorial design optimized the formulation.Results: The nanoemulsion demonstrated improved solubility, thermodynamic stability, and uniform globule size.Conclusion: These results indicate that nanoemulsion technology holds great potential for improving both the solubility and bioavailability of Naftifine hydrochloride for effective topical antifungal therapy.

Keywords: Naftifine hydrochloride; Nanoemulsion; 32 factorial design; Solubility enhancement

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