Volume 47, Issue 1

Original Article

1. Article

   Determination of 4-Chloro-2-chloromethyl-5-(4-chlorophenyl)thieno[2,3-d]- pyrimidine in Rabbit Serum by HPLC and its Application in a Pharmacokinetic Study

   Vanarote D.S, Londhe S.V, Arya. N, Mulgund S.V, Jain K.S

   pp. 1–6 · DOI: · Published 2013

   In drug development, the analytical method development including the bioanalytical method development is essential and useful for the pharmacokinetic study of the lead molecule and is an important step. A sensitive metho…

2. Article

   Development and Validation of a new Reversed-phase HPLC Method for the Determination of Ezetimibe in Pharmaceutical Dosage forms

   Ghanshyam Panjwani, Ragvendra Shetty, Gautham Shenoy, Dinesh Dhamecha

   pp. 7–12 · DOI: · Published 2013

   Ezetimibe belongs to a group of selective and very effective 2-azetidione cholesterol absorption inhibitors that act on the level of cholesterol entry into enterocytes. A new, rapid, specific reversed-phase HPLC method h…

3. Article

   Development and Validation of RP-HPLC and HPTLC Methods for Simultaneous Estimation of Sitagliptin Phosphate and Metformin Hydrochloride in Bulk and Dosage form

   Shailaja B. Jadhav, Swati K. Kupkar, Deepali L. Dharam, Amol M. Jangam, Praveen D. Chaudhari

   pp. 13–16 · DOI: · Published 2013

   Two simple, specific, accurate and precise methods, namely, reverse phase high performance liquid chromatography and high performance thin layer chromatography were developed for simultaneous estimation of Sitagliptin ph…

4. Article

   Design and Evaluation of a Sustained Release Enteric Coated Dosage Form of Fluoxetine Hydrochloride

   Vaishali Thakkar, Yasmin Shaikh, Tejal Soni, Tejal Gandhi

   pp. 17–26 · DOI: · Published 2013

   The purpose of present study was to develop once a day sustained release enteric coated tablet of Fluoxetine HCl by direct compression method. Design was prepared for nine batch using fenugreek mucilage at 40%, 50% and 6…

5. Article

   Enhanced Iontophoretic Delivery of Sumatriptan Succinate from Thermosensitive Gel using Chemical Enhancers

   Swapnil T. Deshpande, Swaroop R. Lahoti, Dinesh L.Dhamecha, Vivek B. Rajendra, Mohd. Hassan G.Dehghan, Prashant K. Puranik

   pp. 27–33 · DOI: · Published 2013

   The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Sumatriptan succinate (SS) by iontophoresis. For better bioavailability, better patient compliance, and enhan…

6. Article

   Taste Masking of Tramadol Hydrochloride by Polymer Carrier System and Formulation of Rapidly Disintegrating Tablets using Factorial Design

   Shilpa N. Shrotriya, Nisharani S. Ranpise, Shraddha T. Bade, P.D Chudiwal

   pp. 34–40 · DOI: · Published 2013

   The objective of this study was to formulate and optimize taste masked rapidly disintegrating tablet of intensely bitter drug tramadol hydrochloride by 32 factorial design. The drug polymer complex was prepared by coacer…

7. Article

   Development and Evaluation of Bilayer Gastroretentive Floating Drug Delivery System for Baclofen

   Ranpise N.S, Kolhe S.R, Ranade A.N

   pp. 41–46 · DOI: · Published 2013

   Baclofen, related to gamma-amino butyric acid (GABA), blocks the activity of nerves within the part of the brain that controls the contraction and relaxation of skeletal muscle. The oral bioavailability of baclofen is ab…

8. Article

   Preparation and Evaluation of Self-nanoemulsifying Formulation of Efavirenz

   Panner Selvam R, Kulkarni P.K, Mudit Dixit

   pp. 47–54 · DOI: · Published 2013

   Efavirenz is an antiretroviral drug which exhibits lower absorption in gastric fluid due to poor water solubility characteristics. Self-nanoemulsifying drug delivery systems (SNEDDS) were designed with the objective of i…

9. Article

   Conceptual Model for Outsourcing Process in Pharmaceutical Supply Chain

   Valentina Marinković, Elizabeta Kostić, Ljiljana Tasić, Vidosav Majstorović

   pp. 55–61 · DOI: · Published 2013

   Pharmaceutical companies are regularly being challenged to meet the rising standards of quality, so as to comply with rigorous regulatory requirements. At the same time, the global pharmaceutical market has seen signific…

10. Article

    Development and Evaluation of Novel Mucoadhesive Multipartculate Drug Delivery System of Simvastatin

    Naga Phani J.V.V, Mohan Varma M

    pp. 62–70 · DOI: · Published 2013

    The objective of the present study was to prepare the mucoadhesive microspheres of simvastatin to provide oral controlled release.Mucoadhesion had been a topic of interest in the design of drug delivery system to prolong…

11. Article

    Anti-depressant - Like Effect of Novel 5-HT Receptor Antagonist, (4- 3 benzylpiperazin-1-yl) (3-methoxyquinoxalin-2-yl)methanone (6g) in Acute and Chronic Animal Models of Depression

    Radhakrishnan Mahesh, Shvetank Bhatt, Thangaraj Devadoss, Ankur Kumar Jindal, Baldev Kumar Gautam, Arghya Kusum Dhar, Dilip Kumar Pandey

    pp. 71–81 · DOI: · Published 2013

    novel 5-HT receptor antagonist '6g' with a good log P and pA value identified from a series of compounds synthesized in our laboratory was subjected to forced 3 2 swim test (FST) (1 and 2 mg/kg, i.p) and tail suspension …

12. Article

    Anti-Psoriatic Activity of Smilax china Linn. Rhizome

    Vijayalakshmi. A, Ravichandiran. V, Malarkodi Velraj, Nirmala. S, Anusha Male, Jayakumari. S, Masilamani. K

    pp. 82–89 · DOI: · Published 2013

    Objectives: The rhizome of the plant Smilax china Linn. has been used in Siddha and Ayurveda in the treatment of Psoriasis and various skin diseases. In the present study, the methanolic extract and ethyl acetate fractio…

13. Article

    Hepato and Nephro-Protective Effect of Methanolic Extract of Vigna mungo (Linn.) Hepper on Rifampicin Induced Toxicity in Albino Rats.

    Nitin. M, Ifthekar. S, Mumtaz. M

    pp. 90–96 · DOI: · Published 2013

    The present study was conducted to investigate the hepatoprotective and nephroprotective activity of methanolic (MEVM) extract of seeds of Vigna mungo (fabaceae) against rifampicin-induced liver and kidney toxicity in ra…

14. Article

    Evaluation of Antidepressant and Antinociceptive Activity of Escitalopram

    Arti Jagtap, Manju Bhaskar

    pp. 97–102 · DOI: · Published 2013

    Escitalopram, the S - (+) -enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. In this present study, antidep…

15. Article

    Isolation of Long Chain Aliphatic Hydrocarbons from Momordica tuberosa (Roxb) Cogn. (Cucurbitaceae) Fruits

    Kale M.S, Laddha K.S

    pp. 103–105 · DOI: · Published 2013

    Long chain saturated hydrocarbons were isolated from petroleum ether extract of Momordica tuberosa (Roxb) Cogn. (Cucurbitaceae) fruits. The petroleum ether extract was subjected to silica gel (mesh size 60-120) column ch…

16. Article

    HIV/AIDS: Preliminary Health Promotion activity based on service-learning principles in Grahamstown, Eastern Cape, South Africa

    Sunitha C Srinivas, Wendy Wrench, Karen Bradshaw, Natisha Dukhi

    pp. 106–112 · DOI: · Published 2013

    Objectives To investigate the effects of a service-learning based health promotion elective on knowledge of HIV & AIDS and ways to prevent them. MethodA computer-based quiz, an information poster, an interactive board ga…