Volume 50, Issue 2S

Pharmaceutical Research

1. Article

   In vitro Antioxidant and Cytotoxic Activities of New Herbal Ointments

   Sirisha Kalam, Kasarla Soujanya, Porika Mahendar, Safia Begum

   pp. s1–s10 · DOI: 10.5530/ijper.50.2.12 · Published 2026

   Objective: The present study was aimed to investigate the possible effect of newer poly herbal ointment formulations against skin cancers. Materials and Methods: The newer polyherbal ointment formulations (PHF-I, PHF-II …

2. Article

   In vitro Anti-oxidant Assay, HPLC Profiling of Polyphenolic Compounds, AAS and FTIR Spectrum of Malaysian Origin Solanum torvum Fruit

   Sathyanarayana Namani, Sunitha Paripelli, Suresh V Chinni, Marimuthu Kasi, Sreeramanan Subramaniam, Xavier Rathinam

   pp. s11–s20 · DOI: 10.5530/ijper.50.2.13 · Published 2026

   Objective: Solanum torvum swartz, a Solanaceae family plant is used by traditional systems of medicine. The aim of this study is to determine the phytochemical content and antioxidant potential of the fruits of Solanum t…

3. Article

   Inhalable Cationic Niosomes of Curcumin Enhanced Drug Delivery and Apoptosis in Lung Cancer Cells

   Kiran Jyoti, Ravi Shankar Pandey, Jitender Madan, Upendra Kumar Jain

   pp. s21–s31 · DOI: 10.5530/ijper.50.2.14 · Published 2026

   Background: Curcumin induces apoptosis in non-small cell lung cancer cells. Hence, inhalable cationic niosomes of curcumin were developed to surmount the poor physicochemical and biopharmaceutical limitations for effecti…

4. Article

   A Comparative Docking Studies of Dichloroacetate Analogues on Four Isozymes of Pyruvate Dehydrogenase Kinase in Humans

   Masood Fereidoonnezhad, Zeinab Faghih, Ayyub Mojaddami, Amirhossein Sakhteman, Zahra Rezaei

   pp. s32–s38 · DOI: 10.5530/ijper.50.2.15 · Published 2026

   Introduction: The four Pyruvate dehydrogenase kinases (PDKs) that regulate the mammalian Pyruvate dehydrogenase complex (PDC) are a novel class of kinases that are expressed in most tissues. PDK is a novel therapeutic ta…

5. Article

   Occurrence of the Triple Whammy in an Outpatient Clinic of a Tertiary Hospital

   Hanis Hanum Zulkifly, Haifak Mat Zaid, Yaman Walid Kassab, Long Chiau Ming, Nahlah Elkudssiah Ismail, Shazwani Shaharuddin

   pp. s39–s44 · DOI: 10.5530/ijper.50.2.16 · Published 2026

   Background: The combination of Non-steroidal Anti-inflammatory Drugs (NSAIDs), Angiotensin-Converting Enzyme Inhibitors (ACEIs) and diuretics, among patients is common. The combination of these drugs can lead to renal di…

6. Article

   Development and in vitro Evaluation of Theophylline Loaded Matrix Tablets Prepared with Direct Compression

   Mehmet Ali Ege, Neslihan Üstündağ Okur, H. Yeşim Karasulu, Tamer Güneri

   pp. s45–s51 · DOI: 10.5530/ijper.50.2.17 · Published 2026

   The objectives of the present study are to develop novel sustained release matrix tablets of theophylline and to evaluate release properties and kinetic behaviour of these tablets. The formulations have been prepared in …

7. Article

   Effect of Memantine and Hespiridine on Monosodium Glutamate Induced Excitotoxicity in Rats

   Namindla Baby Sudha, Akondi Butchi Raju, Anushruti Ashok

   pp. s52–s58 · DOI: 10.5530/ijper.50.2.18 · Published 2026

   Background: Glutamate mediated excitotoxicity is proved to be involved in neurodegenerative diseases like ischemia, trauma, diabetic retinopathy, glaucoma, seizures. Development of specific glutamate antagonists favors a…

8. Article

   Characterization, Partial Purification of Alkaline Protease from Intestinal Waste of Scomberomorus Guttatus and Production of Laundry Detergent with Alkaline Protease Additive

   Gayathri Rengasamy, Daisy Mary Jebaraj, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan

   pp. s59–s67 · DOI: 10.5530/ijper.50.2.19 · Published 2026

   Background: Fish industry wastes are an important environmental contamination source. A way of minimizing the environmental problems generated by the high amount of fish wastes is its transformation to a commercially use…

9. Article

   Solubility Enhancement of Satranidazole Using Self Emulsified Drug Delivery Systems

   Nitin Pandurang Gurav, Panchaxari Mallappa Dandagi, Anand Panchaxari Gadad, Vinayak Shivamurthi Masthiholimath

   pp. s68–s75 · DOI: 10.5530/ijper.50.2.20 · Published 2026

   Background: Satranidazole is an antiprotozoal and antibacterial drug which falls under class II drug as per biopharmaceutical classification systems having poor aqueous solubility. Aim: Therefore, present study was aimed…

10. Article

    Formulation and Evaluation of Gastroretentive Floating Microspheres of Lafutidine

    Anand Panchakshari Gadad, Sneha Shripad Naik, Panchaxari Mallappa Dandagi, Uday Baburao Bolmal

    pp. s76–s81 · DOI: 10.5530/ijper.50.2.21 · Published 2026

    Background: Gastroretentive floating microsphere containing Lafutidine, a second generation histamine H2–receptor antagonist were prepared by ionotropic gelation technique by using sodium alginate, HPMC K4M, ethyl cellul…

11. Article

    Higher Biofilm Formation by Multi-Drug Resistant K. pneumoniae and K. rhinoscleromatis Strains and Effects of Lemon and Ginger Essential Oils on Biofilm Formation

    Gulcan Sahal, Nermin Hande Avcioglu, Isil Seyis Bilkay

    pp. s82–s88 · DOI: 10.5530/ijper.50.2.22 · Published 2026

    Background: Klebsiella strains are opportunistic pathogens forming biofilms on many surfaces. Nowadays some resistance traits’ acquirements via gene transfer mechanisms in biofilm environments cause an urgency to discove…

12. Article

    Development of Extended Release Matrix Tablets of Felodipine Through Solid Dispersions for Better Drug Release Profile by a 32 Factorial Design

    Grandhi Srikar, Prameelarani Avula, Swathi Annapurna, Manasa Boola

    pp. s89–s95 · DOI: 10.5530/ijper.50.2.23 · Published 2026

    Felodipine extended release matrix tablets with slow initial release and long action are suitable for once daily administration and might be good substitutes for immediate acting calcium channel blockers to minimize the …

13. Article

    Thermosensitive In situ Gel for Ocular Delivery of Lomefloxacin

    Anand Panchakshri Gadad, Padmaja Dharmanand Wadklar, Panchakshri Dandghi, Archana Patil

    pp. s96–s105 · DOI: 10.5530/ijper.50.2.24 · Published 2026

    The temperature sensitive in situ gel formulations, undergo phase transition from liquid to semisolid gel upon exposure to physiological eye temperature. These are free-flowing liquid at room temperature and easy to admi…

14. Article

    Colon Targeting Guar Gum Microspheres of 5-Aminosalicylic Acid: Evaluation of Various Process Variables, Characterization and In-vitro Drug Release

    Dinesh Kaushik, Kavita Sharma, Satish Sardana

    pp. s106–s114 · DOI: 10.5530/ijper.50.2.25 · Published 2026

    Background and objectives: 5-Amino salicylic acid (5-ASA), a drug of choice for the treatment of crohn’s disease and ulcerative colitis, rapidly absorbs from the small intestine and there is little localization of 5-ASA …

15. Article

    Design and In vivo Evaluation of Buccoadhesive Hydrophilic Polymer Matrix Films of Losartan Potassium

    Marina Koland, Narayana Rompicherla Charyulu

    pp. s115–s124 · DOI: 10.5530/ijper.50.2.26 · Published 2026

    Introduction: The buccal mucosal route can be considered as an alternative to oral administration for the purpose of improving bioavailability and therapeutic efficacy of drugs such as losartan potassium that suffers fro…

16. Article

    Effects of Salvia virgata Jacq. on Jurkat Clone-E6

    Mükerrem Betül Yerer, Gökçe Şeker Karatoprak, Eren Demirpolat, Müberra KoŞar

    pp. s125–s131 · DOI: 10.5530/ijper.50.2.27 · Published 2026

    Objectives: The genus Salvia is one of the most widespread members of the Lamiaceae family and S.virgata Jacq. decoction is traditionally used for leukemia in Turkey. In this study, water extract and methanol extract of …

17. Article

    Optimization of Transmucosal Buccal Delivery of Losartan Potassium using Factorial Design

    Monica RP Rao, Swati Taktode, Shivraj Sangappa Shivpuje, Shilpa Jagtap

    pp. s132–s139 · DOI: 10.5530/ijper.50.2.28 · Published 2026

    Objective: Buccal delivery is considered to be an important alternative to the peroral route for the systemic administration of drugs. Losartan potassium is an angiotensin II receptor antagonist with an oral bioavailabil…

18. Article

    In Silico Identification of Novel Ligand Molecules for Rabies Nucleoprotein using Structure-Based Method

    Muthukumar Balamurugan, Aril Bhoomigowda, Tanvee Pardesdhi, Sameer Choudhary, Shama Mujawer

    pp. s140–s145 · DOI: 10.5530/ijper.50.2.29 · Published 2026

    Background: Rabies is a life-threatening condition which much privileged in Asia and Africa causes high mortality annually. It has to be treated before showing of any clinical signs. Presently vaccination is the lone acc…

19. Article

    Immunomodulatory Effect of Decalepis hamiltonii Wight and Arn Roots Extract on Rodents

    T. G. Sunitha, Shivsharan Basavraj Dhadde, Sharanbasappa Durg, Syed Mansoor Ahmed, Boreddy Shivanandappa Thippeswamy, Veeresh Prabhakar Veerapur, Baburao NCK

    pp. s146–s152 · DOI: 10.5530/ijper.50.2.30 · Published 2026

    Background: Decalepis hamiltonii Wight and Arn (Asclepiadaceae) commonly known as ‘nannari’ is an Indian medicinal plant which is having ethno-medicinal uses as antioxidant, tonic and blood purifier. It is used in many A…

20. Article

    Dexmedetomidine, Application in Pediatrics: Paper Review

    María Gabriela Pérez-Guillé, Chiharu Murata, Rosa Eugenia Reyes-Reyes, Beatríz Pérez-Guillé, José Bobadilla-Chavez, Radames Alemon-Medina, Ismene Corral-G, Neydi Osnaya-Romero

    pp. s153–s158 · DOI: 10.5530/ijper.50.2.31 · Published 2026

    Introduction: Dexmedetomidine is a drug with sedative, hypnotic, and analgesic properties. Its use in adult sedation was approved in 1999. In children, although the use has not been approved, its application by paediatri…

21. Article

    Natural Gellan Gum (Phytagel®) Based Novel Hydrogel Beads of Rifampicin for Oral Delivery with Improved Functionality

    Jagadevappa Shrimanthrao Patil, Sachin Manik Jadhav, Satish Vasant Mandave, Kailash Vishwanath Vilegave, Shivsharan Basavraj Dhadde

    pp. s159–s167 · DOI: 10.5530/ijper.50.2.32 · Published 2026

    Background: Despite exhaustive global efforts, tuberculosis (TB) continues to higher rates of infection and drug resistance rates are also raising to alarming levels. Sustained release dosage forms are gaining higher acc…

22. Article

    Development of Novel lipid Nanoparticles for oral Bioavailability Enhancement of Irinotecan: In-vitro and In-vivo Investigations

    Zulfiqar Ahmad, Sushama Talegaonkar, Mohammad Tariq, Lalit Mohan Negi, Farhan Jalees Ahmad

    pp. s168–s179 · DOI: 10.5530/ijper.50.2.33 · Published 2026

    Background: Irinotecan is indicated as a first line treatment for metastatic colorectal cancer. However, chemotherapy with irinotecan is restricted to i.v. route owing to poor and erratic oral bioavailability due to its …

23. Article

    Evaluation on Teaching Mentoring Program Based on Reflective Pedagogy Paradigm

    Yosef Wijoyo, Gandes Retno Rahayu, Iwan Dwiprahasto

    pp. s180–s187 · DOI: 10.5530/ijper.50.2.34 · Published 2026

    Background: The aim of Jesuit education in brief is to produce graduates who have the intellectual and emotional capacity to be humanist, open to change, and full of love to serve others. To form graduates with such qual…

24. Article

    Capillary Electrophoresis: MEKC assay method for simultaneous determination of olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide in tablets

    Mahesh Attimarad, Sree Harsha Nagaraja, Bandar Essa Al-Dhubaib, Anroop Balachandran Nair, Venugopala Kattarigatta Narayanaswamy

    pp. s188–s195 · DOI: 10.5530/ijper.50.2.35 · Published 2026

    Objectives: A simple, fast, accurate and precise micellar electrokinetic chromatographic (MEKC) method was developed and validated for the simultaneous quantification of olmesartan medoxomil (OLM), amlodipine besylate (A…